We read with interest the letter entitled “COVID-19 and hydroxychloroquine: is the wonder drug failing ?” by U. Paliani and A. Cordona [1]. This work illustrates the need to be very careful in analyzing the literature at a time when scientific conflicts of this magnitude are taking place. Chloroquine and hydroxychloroquine have moved beyond their practical aspects as drugs or as potential toxic substances to become a clash on several fronts. The countries of the South use hydroxychloroquine and chloroquine on a massive scale, just as they used them before for malaria, or still use them now for systemic lupus erythematosus and rheumatic diseases.
