In their account of the prognostic implications of negative echocardiography in infective endocarditis (IE) the authors made the observation that “molecular imaging may have provided additional information” [1]. That would almost undoubtedly have been the case in their substantial subset of patients with prosthetic valves (PVs) and cardiovascular implantable electronic devices (CIEDs) [1], given the superior diagnostic rate of molecular imaging when IE occurs in that context [2].
