European Journal of Internal Medicine

February 2019

18 Articles

No Section

Association of renin-angiotensin system inhibitors with long-term outcomes in patients with systolic heart failure and moderate-to-severe kidney function impairment

5 February 2019
Author(s): Satoshi Higuchi, Shun Kohsaka, Yasuyuki Shiraishi, Toshiomi Katsuki, Yuji Nagatomo, Atsushi Mizuno, Yasumori Sujino, Takashi Kohno, Ayumi Goda, Tsutomu Yoshikawa, West Tokyo Heart Failure (WET-HF) Registry Investigators

Although guidelines recommend that patients with heart failure with reduced ejection fraction (HFrEF) should be treated with renin-angiotensin system (RAS) inhibitors, the long-term efficacy of RAS... more

The effect of compression stocking on leg edema and discomfort during a 3-hour flight: A randomized controlled trial

6 February 2019
Author(s): Joachim H.H. Olsen, Stina Öberg, Jacob Rosenberg

Compression stockings reduce the risk of thromboembolic complications, leg edema, and edema-related pain and discomfort during long-haul flights. The aim of this study was to assess if compression... more

Syncope in the German Nationwide inpatient sample – Syncope in atrial fibrillation/flutter is related to pulmonary embolism and is accompanied by higher in-hospital mortality

13 February 2019
Author(s): Karsten Keller, Lukas Hobohm, Thomas Münzel, Mir Abolfazl Ostad

Syncope is a common phenomenon in the general population. Although most of the causes are of benign origin, some comorbidities are accompanied by high mortality.We aimed to compare the in-hospital... more

Profiling the hospital-dependent patient in a large academic hospital: Observational study

25 February 2019
Author(s): Andrea Ticinesi, Antonio Nouvenne, Beatrice Prati, Fulvio Lauretani, Ilaria Morelli, Claudio Tana, Massimo Fabi, Tiziana Meschi

In older patients with acute illness, a condition of “hospital-dependence” may arise: patients get adapted to the hospital care and, once discharged, may experience health status decline, requiring... more

Letter to the Editor

Physiological reaction following contrast medium administration: What kind of reaction is this?

1 February 2019
Author(s): Paolo Lombardo, Ingrid Boehm

Although adverse reactions following contrast medium (CM) application occur regularly in routine, radiologists are in most cases not familiar with the clinical reaction patterns. Therefore, the... more

Frailty is associated with multimorbidities due to decreased physical reserve independent of age

2 February 2019
Author(s): Ozlem Yilmaz, Basar Aykent, Pinar Kucukdagli, Cemil Tascioglu, Gulistan Bahat

We read the study of Vancampfort et al. entitled “Handgrip strength, chronic physical conditions and physical multimorbidity in middle-aged and older adults in six low- and middle income countries”... more

Haemoptysis as a presenting feature of hepatopulmonary disease

4 February 2019
Author(s): Oscar M.P. Jolobe

The report of haemoptysis as a presenting feature of hepatic-pulmonary disease [1] is testimony to the importance of hepatic-pulmonary disease in the differential diagnosis of haemoptysis. This... more

Raynaud's phenomenon and inflammatory bowel disease: The possible role of microcirculation

6 February 2019
Author(s): Vera R. Bernardino, Ana Catarina Rodrigues, António Panarra

Vascular pathology is increasingly more recognized as an extra-intestinal manifestation of Inflammatory Bowel Disease (IBD) [1,2]. Raynaud's phenomenon (RP), a syndrome characterized by recurrent... more

Comment to “Impact of Daylight Saving Time on circadian timing system: An expert statement”

19 February 2019
Author(s): José María Martín-Olalla

The impact of Daylight Saving Time (DST) on daily life has gained a lot of attention in the past few years and, notably, in the past months since the European Commission addressed the issue. It was... more

Comment to “Impact of Daylight Saving Time on circadian timing system: An expert statement”. Authors' reply

26 February 2019
Author(s): Roberto Manfredini, Miguel Meira e Cruz

We appreciated the sophisticated and learned dissertation by Dr. Martìn-Olalla [1], based on solid and interesting perspectives.

Original Article

Reactive thrombocytosis in acute infectious diseases: Prevalence, characteristics and timing

19 February 2019
Author(s): Ami Schattner, Jaber Kadi, Ina Dubin

Reactive thrombocytosis is known to occur in infectious, inflammatory and neoplastic diseases. However, the characteristics of its association with acute infections (ID) has not been systematically... more

Iron supplementation for restless legs syndrome – A systematic review and meta-analysis

21 February 2019
Author(s): Tomer Avni, Shelley Reich, Nirit Lev, Anat Gafter-Gvili

Iron supplementation, is recommended for the treatment of restless legs syndrome (RLS). We gathered evidence for the efficacy and safety of iron supplementation for RLS.

Factors associated with length of stay in hospital for men and women aged 85 and over: A quantile regression approach

22 February 2019
Author(s): Xenia Dolja-Gore, Melissa L. Harris, Hal Kendig, Julie E. Byles

Explore characteristics of hospital use for adults aged 85 and over in their last year of life and examine factors associated with cumulative overnight length of stay (LOS).

Association of systemic beta-defensin-1 and -20G/A DEFB1 gene polymorphism with Behçet's disease

26 February 2019
Author(s): Amani Kallel, Thouraya Ben Salem, Mohamed Bassem Hammami, Fatma Said, Riadh Jemaa, Mohamed Habib Houman, Moncef Feki

Behçet's disease (BD) is a multisystem inflammatory disease of unknown etiology. Beta-defensins are antimicrobial peptides involved in epithelial host defense. To explore whether beta-defensins might... more

Review Article

European and US guidelines for arterial hypertension: similarities and differences

4 February 2019
Author(s): Fabio Angeli, Gianpaolo Reboldi, Monica Trapasso, Giorgio Gentile, Maria Gabriella Pinzagli, Adolfo Aita, Paolo Verdecchia

Hypertension is one of the most common chronic diseases in adults and a leading cause of disability and mortality worldwide. Recently, new Guidelines for the diagnosis and management of hypertension... more

Special Article

Grantsmanship writing tips: background, hypothesis and aims

15 February 2019
Author(s): Chiara Gabbi, R. Michelle Sauer

In the current article, we discuss the effective writing strategies for research grant proposal's background/introduction and specific aims/objective sections. These key components are often found in... more

Grantsmanship writing tips: significance, innovation and impact

22 February 2019
Author(s): R. Michelle Sauer, Chiara Gabbi

In this fourth and last special article on grantsmanship [1–3], we discuss the strategies to write competitive “Significance,” “Innovation,” and “Impact” sections, when required. Several sponsors... more

Grantsmanship writing tips: the experimental design

25 February 2019
Author(s): Chiara Gabbi, R. Michelle Sauer

Our prior editorials have discussed the basic principles of grantsmanship [1] and the writing approach for the background, hypothesis, specific aims sections [2]. Herein we present the effective... more