Lyme Borreliosis (LB) is a tick-borne disease caused by Borrelia burgdorferi sensu lato (s.l.). Patients present with several specific manifestations, of which an erythema migrans (EM) occurs most frequently. However, patients suspected for LB are also referred to Lyme centres with solely non-specific symptoms and positive Borrelia serology. The most common non-specific symptoms in patients referred to a Lyme centre are severe fatigue, sleep disturbances, and stiffness in neck and/or back [1].
