Proton pump inhibitors (PPIs) are among the most widely prescribed agents [1]. For over 30 years, guidelines promote PPIs as the best treatment of gastroesophageal reflux disease (GERD), esophagitis, and peptic ulcer disease [2]. Importantly, PPIs are increasingly prescribed for prolonged, even lifelong, prophylactic use, often without a compelling indication [3]. However, over the last several years there is a growing number of reports associating chronic PPI use with a variety of serious adverse effects [4].
