Published: 24 June 2022
Author(s): Yue Li, Huajie Liu, Jingzhi Wang, Wangqiu Gong, Xia Gao
Issue: October 2022
Section: Letter to the Editor

Primary nephrotic syndrome (PNS) is characterized by massive proteinuria, hypoproteinemia, edema and hyperlipidemia. Angiopoietin like protein 4 (ANGPTL4) is a secretory glycoprotein and belongs to the angiopoietin-like protein family. It's well known that ANGPTL4 is a key regulator of lipid metabolism and has been widely reported in metabolic diseases and cardiovascular diseases [1]. Recently, it was reported that ANGPTL4 secreted by glomerular podocytes aggravates podocyte injury and it is closely related to proteinuria in rats with nephrotic syndrome (NS) [2].

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