Published: 16 April 2020
Author(s): Miriana d'Alessandro, Laura Bergantini, Anna Perrone, Paolo Cameli, Matteo Cameli, Antje Prasse, Dario Plataroti, Piersante Sestini, Elena Bargagli
Issue: August 2020
Section: Original article

Sarcoidosis is a systemic granulomatous disease associated with T lymphocyte and macrophage activation and migration into affected organs. The interaction between antigens and antigen-presenting cells polarizes T lymphocytes to the T helper 1 phenotype (Th1), leading to the formation of sarcoid granulomas consisting of T cells, macrophages, epithelioid and giant cells [1]. The course of sarcoidosis is unpredictable: remission occurs in most cases, while persistent granuloma inflammation may lead to fibrotic lung disease [2, 3].


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