December 2018

17 Articles

No Section

Nipple shadows

23 December 2018
Author(s): Song Soo Kim, Hyo Jin Lee

A 49-year-old female was being followed-up for malignant melanoma after surgery. Six months earlier, she had undergone amputation of right 4th finger and sentinel lymph node biopsy. A medical history... more

Computerized algorithms compared with a nephrologist's diagnosis of acute kidney injury in the emergency department

11 December 2018
Author(s): Arnar Jan Jonsson, Ingibjorg Kristjansdottir, Sigrun Helga Lund, Runolfur Palsson, Olafur S. Indridason

The aim of this study was to examine acute kidney injury (AKI) diagnosis based on different computerized algorithms compared with a nephrologist's diagnosis in patients visiting an emergency... more

Bringing complexity into clinical practice: An internistic approach

6 December 2018
Author(s): Gino Roberto Corazza, Pietro Formagnana, Marco Vincenzo Lenti

Modern medicine, still largely focused on single diseases, is unprepared for managing clinical complexity (CC), which is an emerging issue. Ageing of the general population has favoured the... more

Management of celiac disease in daily clinical practice

5 December 2018
Author(s): Luca Elli, Francesca Ferretti, Stefania Orlando, Maurizio Vecchi, Erika Monguzzi, Leda Roncoroni, Detlef Schuppan

Celiac disease (CD) is the most common autoimmune enteropathy worldwide. In CD, dietary gluten triggers a T cell driven small intestinal inflammation in a subset of genetically predisposed subjects,... more

Myelodysplastic syndromes and acute myeloid leukemias in the elderly

1 December 2018
Author(s): Beatrice U. Mueller, Katja Seipel, Thomas Pabst

Most patients above 60 years with acute myeloid leukemia (AML) will die from their disease. Nevertheless, the treatment concepts in elderly patients with myelodysplastic syndromes (MDS) and AML are... more

Management of unfit elderly patients with chronic lymphocytic leukemia

1 December 2018
Author(s): Barbara Eichhorst, Michael Hallek, Valentin Goede

Chronic lymphocytic leukemia (CLL) is a disease characterized by an increasing incidence with age reaching 35/100,000 in patients over 85 years. Elderly CLL patients carry several challenges, which... more

Antipsychotics and severe hyponatremia: A Swedish population–based case–control study

1 December 2018
Author(s): Henrik Falhammar, Jonatan D. Lindh, Jan Calissendorff, Jakob Skov, David Nathanson, Buster Mannheimer

Antipsychotics have been claimed to cause hyponatremia. The risk associated with individual antipsychotics, or groups (first-generation [FGAs] or second-generation [SGAs] antipsychotics), is not well... more

Chemotherapy-free and reduced intensity approaches in elderly patients with B-lineage acute lymphoblastic leukemia

1 December 2018
Author(s): Sabina Chiaretti, Robin Foà

Management of older patients - defined by convention above the age of 60 years, but varying widely within study groups - with acute lymphoblastic leukemia (ALL) is still a challenge. The complete... more

Internal Medicine Flashcard

A young woman with left lower chest pain

26 December 2018
Author(s): Samrad Mehrabi, Behnam Dalfardi

A 34-years old woman presented to the emergency department with complaints of acute-onset and progressive left upper quadrant abdominal and left lower chest pain, nausea, and fever since about 4 days... more

Atypical rash

26 December 2018
Author(s): Juan Carlos Cataño, Diego E. Giraldo

A 42-year-old hypothyroid woman, who lived her entire life in a rural place of Colombia, used to hunt and eat Armadillo over several years when she was a child, and now presented to the emergency... more

Invited Article

Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly

1 December 2018
Author(s): Wilma Barcellini, Bruno Fattizzo, Agostino Cortelezzi

The physiology of the immune system involves morphologic and functional changes occurring along ageing, with a decrease in immune response and an increase in autoimmune phenomena, even in the absence... more

Special problems in the management of elderly patients with multiple myeloma

1 December 2018
Author(s): Francesca Gay, Alessandra Larocca

Multiple myeloma (MM) is a neoplastic disease typical of the elderly. Many steps forward have been made in the characterization of patients, and new treatment strategies are available today. Clinical... more

Letter to the Editor

Risk of hypoglycemia in hospitalized patients with diabetes mellitus

29 December 2018
Author(s): Jan Brož, Aneta Nyčová

We read with interest the review article by Yosefa Bar-Dayan et al., “Hypoglycemia-simplifying the ways to predict an old problem in the general ward” that has been published online in the European... more

Management of celiac disease in daily clinical practice: do not forget depression!

28 December 2018
Author(s): Antonio Mirijello, Cristina d'Angelo, Salvatore De Cosmo, Antonio Gasbarrini, Giovanni Addolorato


Original Article

Multimorbidity in middle age predicts more subsequent hospital admissions than in older age: A nine-year retrospective cohort study of 121,188 discharged in-patients

20 December 2018
Author(s): Francisco T.T. Lai, Samuel Y.S. Wong, Benjamin H.K. Yip, Bruce Guthrie, Stewart W. Mercer, Roger Y. Chung, Gary K.K. Chung, Patsy Y.K. Chau, Eliza L.Y. Wong, Jean Woo, Eng-Kiong Yeoh

Previous research has suggested a differential short-term effect of multimorbidity on hospitalization by age, with younger groups affected more. This study compares the nine-year hospitalization... more

Impact of anemia as risk factor for major bleeding and mortality in patients with acute coronary syndrome

19 December 2018
Author(s): Nuria Vicente-Ibarra, Francisco Marín, Vicente Pernías-Escrig, Miriam Sandín-Rollán, Laura Núñez-Martínez, Teresa Lozano, Manuel Jesús Macías-Villaniego, Luna Carrillo-Alemán, Elena Candela-Sánchez, Elena Guzmán, María Asunción Esteve-Pastor, Esteban Orenes-Piñero, Mariano Valdés, José Miguel Rivera-Caravaca, Juan M. Ruiz-Nodar

Anemia is frequent in acute coronary syndrome (ACS) patients and is associated with worse clinical outcomes. We aimed to investigate the therapeutic strategies, the use of novel P2Y12 inhibitors, and... more

Mortality rate and risk factors for gastrointestinal bleeding in elderly patients

3 December 2018
Author(s): Marco Vincenzo Lenti, Luca Pasina, Sara Cococcia, Laura Cortesi, Emanuela Miceli, Costanza Caccia Dominioni, Martina Pisati, Caterina Mengoli, Francesco Perticone, Alessandro Nobili, Antonio Di Sabatino, Gino Roberto Corazza, REPOSI Investigators

Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB... more


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