June 2017

27 Articles

No Section

Primary biliary cholangitis: Old and novel therapy

29 June 2017
Author(s): Annarosa Floreani, Chiara Mangini

Primary biliary cholangitis (PBC), formerly called primary biliary cirrhosis, is a chronic cholestatic liver disease that progresses slowly to end-stage liver disease. The first Food and Drug... more


The rise of artificial intelligence and the uncertain future for physicians

24 June 2017
Author(s): C. Krittanawong

Physicians in everyday clinical practice are under pressure to innovate faster than ever because of the rapid, exponential growth in healthcare data. “Big data” refers to extremely large data sets... more

Comparing SF-36® scores versus biomarkers to predict mortality in primary cardiac prevention patients

15 June 2017
Author(s): Rony Lahoud, Vasutakarn Chongthammakun, Yuping Wu, Nael Hawwa, Danielle M. Brennan, Leslie Cho

Risk stratification plays an important role in evaluating patients with no known cardiovascular disease (CVD). Few studies have investigated health-related quality of life questionnaires such as the... more

Letter to the Editor

Positive predictive value of hospital discharge diagnosis code to identify immunoglobulin A vasculitis in France: A validation study

24 June 2017
Author(s): Samuel Deshayes, Guillaume Moulis, Evangeline Pillebout, Achille Aouba, Alexandra Audemard-Verger

Immunoglobulin A vasculitis (IgAV), formerly called Schonlein-Henoch purpura, belongs to immune complex small vessel vasculitis. IgAV is the most common vasculitis in childhood but is more rare in... more

Effect of ZIKA virus on adult eyes

20 June 2017
Author(s): Dhrubajyoti Bandyopadhyay, Arshna Qureshi, Kumar Ashish, Adrija Hajra, Sandipan Chakraborty

First I would like to thank Dr. Wiwanitkit for raising the very pertinent point regarding the effect of Zika virus (ZIKV) in adult eyes. We discussed the various ocular manifestations of ZIKV in... more

Helping ethics committees separate the wheat from the chaff

17 June 2017
Author(s): Vittorio Bertele', Chiara Gerardi, Silvio Garattini

Disappointingly most clinical research is wasteful as it is either futile or risky for patients [1]. Often its questions pursue aims other than the unmet clinical needs they claim to address, and... more

Is homeopathy a medicine?

16 June 2017
Author(s): Salvatore Chirumbolo

In a recent Editorial published in this journal, Garattini and Mannucci wondered if outpatient homeopathy clinics and commercially available homeopathic products are yet deceiving people [1]. They... more

Eye problem in Zika virus infection

13 June 2017
Author(s): Viroj Wiwanitkit

The recent publication on Zika virus infection is very interesting [1]. As noted by Bandyopadhyay and Hajra, there are several possible eye problems due to Zika virus infection [1]. An important... more

Lifestyle changes as internal medicine

13 June 2017
Author(s): Daniela Lucini, Chiara Vigo, Mara Malacarne, Wolfgang Gatzemeier, Massimo Pagani

Optimization of body weight by following healthy diet, physical activity program and stop smoking, are cornerstone strategies in prevention/treatment of major chronic diseases [1] from cardio-... more

Nitrates and osteoporosis: Which relationship?

8 June 2017
Author(s): Marco Zuin, Gianluca Rigatelli, Fiorenzo Scaranello, Loris Roncon

Osteoporosis and related risk of fracture represent a major a common clinical condition and a major health problem, especially in elderly patients creating huge costs to the health care system [1].... more

The use of nutritional risk screening 2002 to predict prognosis in hospitalized patients with chronic obstructive pulmonary disease with respiratory failure

5 June 2017
Author(s): Ruiqi Chen, Lu Xing, Chao You

Due to the increasing energy expenditure, hospitalized patients with chronic obstructive pulmonary disease (COPD) with respiratory failure are susceptible to nutritional risks [1]. It was reported... more

Factors associated with mild cognitive impairment in a population-based cohort

2 June 2017
Author(s): Silvio Buscemi, Valeria Di Pasquale, Carola Buscemi, Tommaso Piccoli, Carla Giordano

Dementia is currently a public health priority, covering about 8% of people over the age of sixty-five, 20% of the population over 80years of age in the Western world, and it is expected that these... more

Narrative Review

Alcoholic cardiomyopathy: What is known and what is not known

21 June 2017
Author(s): Antonio Mirijello, Claudia Tarli, Gabriele Angelo Vassallo, Luisa Sestito, Mariangela Antonelli, Cristina d'Angelo, Anna Ferrulli, Salvatore De Cosmo, Antonio Gasbarrini, Giovanni Addolorato

Excessive alcohol consumption represents one of the main causes of non-ischemic dilated cardiomyopathy. Alcoholic cardiomyopathy is characterized by dilation and impaired contraction of one or both... more

Brugada syndrome: A general cardiologist's perspective

20 June 2017
Author(s): Marija M. Polovina, Milica Vukicevic, Bojan Banko, Gregory Y.H. Lip, Tatjana S. Potpara

Brugada syndrome (BrS) is one of the commonest inherited primary arrhythmia syndromes typically presenting with arrhythmic syncope or sudden cardiac death (SCD) due to polymorphic ventricular... more

Original Article

Time to antibiotics administration and outcome in community-acquired pneumonia: Secondary analysis of a randomized controlled trial

23 June 2017
Author(s): Christophe Marti, Gregor John, Daniel Genné, Virginie Prendki, Olivier T. Rutschmann, Jérôme Stirnemann, Nicolas Garin

The association between early antibiotic administration and outcomes remains controversial in patients hospitalized for community-acquired pneumonia.

Association between hospitalization for acute medical illness and VTE risk: A lower efficacy of thromboprophylaxis in elderly patients? Results from the EDITH case-control study

21 June 2017
Author(s): Florence Hemon, Fabrice Fouchard, Cécile Tromeur, Karine Lacut, Grégoire Le Gal, Dominique Mottier, Francis Couturaud, Aurélien Delluc

Whether the association between hospitalization and venous thromboembolism (VTE) is modified by the use of thromboprophylaxis in older patients remains insufficiently evaluated. Our objective was to... more

Re-emerging infectious diseases from the past: Hysteria or real risk?

19 June 2017
Author(s): Charlier Philippe, Claverie Jean-Michel, Sansonetti Philippe, Coppens Yves, Augias Anaïs, Jacqueline Sophie, Rengot Fanny, Deo Saudamini

Work on human remains and old biological samples is a potential source of contamination by conventional or atypical infectious agents. Similarly, current and future environmental changes are a source... more

A one-year mortality clinical prediction rule for patients with heart failure

18 June 2017
Author(s): Antonio Escobar, Lidia García-Pérez, Gemma Navarro, Amaia Bilbao, Raul Quiros, On behalf of the CACE-HF Score group

To create and validate a clinical prediction rule which is easy to manage, reproducible and that allows classifying patients admitted for heart failure according to their one-year mortality risk.

Protective effect of N-acetylcysteine on progression to end-stage renal disease: Necessity for prospective clinical trial

17 June 2017
Author(s): Chen-Yi Liao, Chi-Hsiang Chung, Chai-Chao Wu, Fu-Huang Lin, Chang-Huei Tsao, Chih-Chiang Wang, Wu-Chien Chien

We aimed to evaluate the potential benefits of N-acetylcysteine (NAC) on the risk of chronic kidney disease (CKD) progression to dialysis-requiring end-stage renal disease (ESRDd).

Oral glucose-stimulated growth hormone (GH) test in adult GH deficiency patients and controls: Potential utility of a novel test

13 June 2017
Author(s): Lara Pena-Bello, Teresa Seoane-Pillado, Susana Sangiao-Alvarellos, Elena Outeiriño-Blanco, Barbara Varela-Rodriguez, Paula Juiz-Valiña, María Cordido, Fernando Cordido

The diagnosis of adult GH deficiency requires confirmation with a GH stimulation test. Oral glucose (OG) administration affects GH secretion, initially decreasing and subsequently stimulating GH... more

Impact of COPD on outcomes in hospitalized patients with community-acquired pneumonia: Analysis of the Spanish national hospital discharge database (2004–2013)

11 June 2017
Author(s): Javier de Miguel-Díez, Ana López-de-Andrés, Valentín Hernández-Barrera, Isabel Jiménez-Trujillo, Manuel Méndez-Bailón, José M. de Miguel-Yanes, Rodrigo Jiménez-García

To examine trends in incidence and outcomes of community-acquired pneumonia (CAP) hospitalizations among patients with or without COPD in Spain (2004–2013).

Impact of periodontal treatment on hospitalization for adverse respiratory events in asthmatic adults: A propensity-matched cohort study

7 June 2017
Author(s): Te-Chun Shen, Pei-Ying Chang, Cheng-Li Lin, Chang-Ching Wei, Chih-Yen Tu, Te-Chun Hsia, Chuen-Ming Shih, Wu-Huei Hsu, Fung-Chang Sung, Chia-Hung Kao

Periodontal disease is prevalent in asthmatics, but it is unclear whether periodontal treatment plays a role in adverse respiratory events in these patients. We evaluated risk of hospitalization for... more

Occurrence of malignant neoplasia in patients with primary hyperparathyroidism

5 June 2017
Author(s): Serena Palmieri, Letizia Roggero, Elisa Cairoli, Valentina Morelli, Alfredo Scillitani, Iacopo Chiodini, Cristina Eller-Vainicher

The association between primary hyperparathyroidism (1HPT) and cancer is debated. The present study was aimed to investigate the occurrence of neoplasia in 1HPT.

Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people: Population based prospective cohort study

2 June 2017
Author(s): Sasmita Kusumastuti, Thomas Alexander Gerds, Rikke Lund, Erik Lykke Mortensen, Rudi G.J. Westendorp

To investigate the added value of comorbidity, frailty, and subjective health to mortality predictions in community-dwelling older people and whether it changes with increasing age.

A comparative analysis of novel cardiovascular biomarkers in patients with chronic heart failure

1 June 2017
Author(s): Michael Lichtenauer, Peter Jirak, Bernhard Wernly, Vera Paar, Ilonka Rohm, Christian Jung, Christiana Schernthaner, Johannes Kraus, Lukas J. Motloch, Atilla Yilmaz, Uta C. Hoppe, P. Christian Schulze, Daniel Kretzschmar, Rudin Pistulli

Heart failure (HF) with reduced ejection fraction remains a major therapeutic challenge. The aim of this study was to investigate the role of novel cardiovascular biomarkers, i.e. soluble suppression... more

Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk

1 June 2017
Author(s): Bernardine H. Stegeman, Hans L. Vos, Frans M. Helmerhorst, Frits R. Rosendaal, Pieter H. Reitsma, Astrid van Hylckama Vlieg

Use of ethinylestradiol, one of the active ingredients in combined oral contraceptives, affects the incidence of venous thrombosis. To explain why some women develop thrombosis when using oral... more

Review Article

Portopulmonary hypertension and hepatorenal syndrome. Two faces of the same coin

3 June 2017
Author(s): Enrico Maria Zardi, Domenico Maria Zardi, Chiara Giorgi, Diana Chin, Aldo Dobrina

Portopulmonary hypertension and hepatorenal syndrome are both severe local hypertensive complications of liver cirrhosis and portal hypertension. Both are characterized by vasoconstrictive... more


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