May 2024

71 Articles

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Exploring the Landscape of Familial Hypercholesterolemia: Unraveling Genetic Complexity and Clinical Implications

4 March 2024
Author(s): Fotios Barkas, Evangelos Liberopoulos, Manfredi Rizzo

Familial hypercholesterolaemia (FH) is the most encountered inherited metabolic disorder and is associated with premature cardiovascular disease.[1] Although early diagnosis is imperative for... more

Clinical Insights

Monkeypox infection, 18 months later: A vanishing epidemic?

17 February 2024
Author(s): F. Patauner, R. Gallo, E. Durante-Mangoni, L. Bertolino

On July 25, 2022, the World Health Organization (WHO) declared the Monkeypox (MPX) outbreak a ‘public health emergency of international concern’. Indeed, starting from May 2022, 92,783 cases have... more

Detection of subclinical atrial fibrillation with cardiac implanted electronic devices: What decision making on anticoagulation after the NOAH and ARTESiA trials?

27 January 2024
Author(s): Giuseppe Boriani, Luigi Gerra, Davide A Mei, Niccolo’ Bonini, Marco Vitolo, Marco Proietti, Jacopo F Imberti

Atrial fibrillation (AF) may be asymptomatic and the extensive monitoring capabilities of cardiac implantable electronic devices (CIEDs) revealed asymptomatic atrial tachi-arrhythmias of short... more

The lowest well tolerated blood pressure: A personalized target for all?

25 January 2024
Author(s): Paolo Verdecchia, Fabio Angeli, Gianpaolo Reboldi

Among the various clinical aspects related to the management of hypertension, the choice of blood pressure (BP) targets is probably one of the most challenging. Unfortunately, there is disagreement... more


When to prescribe oral anticoagulation for patients with device-detected subclinical atrial fibrillation? Insights from the NOAH-AFNET 6 and ARTESiA trials

9 April 2024
Author(s): William F. McIntyre, Jeffrey S. Healey, Renato D. Lopes

Device-detected, subclinical atrial fibrillation (AF), previously known as atrial high-rate episodes, is detected in roughly one-third of older patients with a pacemaker, defibrillator, or implanted... more

Subclinical atrial fibrillation patients, who are the best candidates for oral anticoagulant therapy?

20 March 2024
Author(s): Bi Huang, David J. Wright, Gregory Y.H. Lip

Conventionally, atrial fibrillation (AF) is diagnosed by surface electrocardiogram (ECG) while cardiac implantable electronic devices (CIEDs) provides information of the cardiac electrical activity... more

Estimation of renal function: Different markers for different outcomes?

13 March 2024
Author(s): Claudio Pedone, Raffaele Antonelli Incalzi

Sarcopenia is a condition characterized by loss of muscle strength and mass that is strongly associated with age and age-related conditions, and is therefore considered a typically geriatric disease... more

Direct oral anticoagulants: The new standard of care for cancer associated thrombosis

8 March 2024
Author(s): Marcello Di Nisio, Agnes Y Lee

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), often complicates the course of cancer disease and represents an invariably distressing experience for... more

Action points for implementation of the lowest well-tolerated blood pressure

2 March 2024
Author(s): De-Wei An, Yan Li, Jan A. Staessen

In a seminal review of hypertension trials [1], Verdecchia and coworkers noticed that more intensive compared to usual blood pressure (BP) control reduced major cardiovascular complications (MACE),... more

Combining electrocardiographic and echocardiographic indexes to detect cardiac amyloidosis: A step forward in the quest to diagnose cardiac amyloidosis without delay

19 February 2024
Author(s): Steven A Muller, Hugh Calkins, Alessio Gasperetti

Cardiac amyloidosis (CA) is a progressive and life-threatening cardiomyopathy characterized by deposition of misfolded proteins in the myocardium, leading to heart failure (HF), conduction disorders... more

A call to action: The need to apply guidelines recommendations with ABC or SOS to improve stroke prevention and cardiovascular outcomes in patients with atrial fibrillation

2 February 2024
Author(s): Giuseppe Boriani, Enrico Tartaglia, Jacopo F. Imberti

Atrial fibrillation (AF) and stroke are deeply interlinked, as AF may precede ischemic stroke, thus being related to cardioembolism, but also manifest after both ischemic and hemorrhagic stroke [1].

Uncomplicated outpatient deep venous thrombosis management with a novel care pathway: Is it ready for prime time?

30 January 2024
Author(s): Alejandro Godoy, Stephanie Carlin, James D. Douketis

The standard-of-care for patients presenting to a general practitioner (GP) with suspected deep vein thrombosis (DVT) in many regions involves the use of a clinical decision rule and/or a d-dimer... more

Stressful experiences and venous thromboembolism

27 January 2024
Author(s): Arina ten Cate-Hoek, Hugo ten Cate

Despite stress being an accepted cause of arterial thrombotic events (ATE) [1,2], for which underlying pathophysiological processes have also been identified, it has not yet been widely recognised as... more


New horizons in the diagnosis and management of patients with MASLD

12 February 2024
Author(s): Karel J. van Erpecum, George N. Dalekos

The collection 'New horizons in the diagnosis and management of patients with metabolic dysfunction-associated steatotic liver disease (MASLD)’ that is presented here, deals with the natural history... more


Acute heart failure – an EFIM guideline critical appraisal and adaptation for internists

6 March 2024
Author(s): Valentin A. Kokorin, Alvaro González-Franco, Antonio Cittadini, Oskars Kalejs, Vera N. Larina, Alberto M. Marra, Francisco J. Medrano, Zdenek Monhart, Laura Morbidoni, Joana Pimenta, Wiktoria Lesniak

Over the past two decades, several studies have been conducted that have tried to answer questions on management of patients with acute heart failure (AHF) in terms of diagnosis and treatment.... more

Ideas and Opinions

Is full transparency in clinical trials an achievable goal?

8 March 2024
Author(s): Rafael Dal-Ré

In the last two decades several requirements have been developed to enhance clinical trials transparency. Some are encouraged or recommended by ethics codes, journal editors, or funders. Others are... more

Internal Medicine Flashcard

A man with darkened neck

5 March 2024
Author(s): Xin Nie, Zhixin Bie, Lin Li

A 65-year-old man presented with a 12-month history of gradual darkening of his neck. He also reported a progressive increased right side mandibular mass and a weight loss of 4 kg over 3 months. He... more

Difficult to treat rheumatoid arthritis: Why profound differential diagnosis is important

28 February 2024
Author(s): Nils Schulz, Uwe Lange, Philipp Klemm

A 47-year-old patient was referred to our rheumatology department due to treatment refractory rheumatoid arthritis, characterized by polyarthralgia, progressive joint destruction, and impaired... more

A young man with amnesia after drug overdose

24 February 2024
Author(s): Dhairya A. Lakhani, Francis Deng

A 29-year-old man was found unconscious on the side of the road. Examination revealed pinpoint pupils and bradypnea. He regained consciousness after intranasal naloxone.

Pruritic papules and reticular pigmentation

19 February 2024
Author(s): Boyang Liu, Mengqi Lv, Jinbo Chen

A 21-year-old male with a previous history of good health. One month earlier, scattered, pruritic, red papules and maculopapules had developed on the chest and back. After papules fades, left light... more

Beau‘s lines in a man with lower limb burning sensation

17 February 2024
Author(s): Tsuyoshi Furuya, Yoshiaki Furukawa

A 49-year-old man presented with several months of burning sensation and numbness in the lower extremities. According to his statement of the medical history, there were no excessive drinking, intake... more

Invited Review Article

Management of cardiovascular risk in patients with metabolic dysfunction-associated steatotic liver disease

25 November 2023
Author(s): Anders Mellemkjær, Mikkel Breinholt Kjær, David Haldrup, Henning Grønbæk, Karen Louise Thomsen

Non-alcoholic fatty liver disease (NAFLD) has for years been the most common liver disease worldwide. In 2016, the prevalence of NAFLD was estimated to be approximately 25 % [1], and recent reports... more

Letter to the Editor

Bleeding heralding the diagnosis of essential thrombocythemia

9 March 2024
Author(s): Grégoire Stalder, Francesco Grandoni, Lorenzo Alberio

We appreciate the opportunity to reply to the Letter to the Editor of Yang et al. [1], which refers to our recent publication [2] in order to present a case with a complementary clinical issue.

Benefits and challenges of bronchoalveolar lavage in immunocompromised patients

8 March 2024
Author(s): Hiroshi Ito

Jahn K et al. conducted a prospective single-center observational study and found that treatment management changed in approximately half of the patients with immunocompromised lower respiratory... more

Association between direct oral anticoagulants and risk of gastrointestinal bleeding

21 February 2024
Author(s): I-Wen Chen, Chia-Li Kao, Chun-Ning Ho, Kuo-Chuan Hung

We read with great interest the systematic review and meta-analysis by Kyriakoulis et al. comparing direct oral anticoagulants (DOACs) with vitamin K antagonists (VKAs) in patients with atrial... more

Patient centered care: A multidisciplinary and holistic approach

20 February 2024
Author(s): Giovambattista Desideri, Nicola Montano, Giorgio Sesti

Modern medical care is increasingly underpinned by evidence-based guidelines which are widely viewed as a cornerstone of current efforts to define standards of care and improve the quality of... more

The impact of sodium-glucose cotransporter-2 inhibitors on cardiac function

19 February 2024
Author(s): I-Wen Chen, Hsiu-Lan Weng, Kuo-Chuan Hung

Dear Editor,

Comparing the risk of dementia in patients with atrial fibrillation taking different oral anticoagulants

17 February 2024
Author(s): Sheng-Feng Sung, Hsin-Yi Yang, Ching-Fang Tsai, Chen-Wen Fang

Dear editor,

Efficacy and safety of eplerenone in heart failure management

15 February 2024
Author(s): Jin Zheng, Shuangao Wang, Ana Teresa Timóteo

Dear Editor,

Prevalence of post-COVID symptoms one-year after SARS-CoV-2 infection in patients with interstitial lung disease

6 February 2024
Author(s): Paula Parás-Bravo, César Fernández-de-las-Peñas, Diego Ferrer-Pargada, Sheila Izquierdo-Cuervo, Manuel Herrero-Montes

The Global Burden of Disease Study revealed that chronic respiratory diseases remain to be leading cause of death and disability worldwide [1]. In the recent years, the world has experienced a... more

MEFV gene mutation (c.229G>T) as a cause of fever of unknown origin

5 February 2024
Author(s): Jose Pablo Miramontes-González, Andreea Catalina Cristea, Miriam Gabella Martín, María González Fernández, José Luis Pérez-Castrillón

Fever of unknown origin (FUO) was traditionally characterized by a temperature exceeding 38.3 °C on at least three occasions over a period of at least three weeks, with no apparent cause despite one... more

ACE inhibitors and lung cancer: There is more to it than just a cough

3 February 2024
Author(s): Muhammad Ahmad, Malik Waleed Zeb Khan, Shandana Ali, Salman Khan, Shakir Ullah

We are writing to highlight the findings of a recent meta-analysis suggesting a possible relationship between the long-term use of angiotensin-converting enzyme inhibitors (ACEIs) and an increased... more

Efficacy of canakinumab for mosaic tumor necrosis factor receptor associated periodic syndrome

2 February 2024
Author(s): Alexandre Terré, Mathieu Vautier, Jean-Emmanuel Kahn, Sophie Georgin-Lavialle, Guilaine Boursier

Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS) is one of the first monogenic autoinflammatory diseases to be described [1]. TRAPS is a dominant disease due to mutations in the... more

Longitudinal trends in acute pulmonary embolism hospitalizations during the COVID-19 pandemic

2 February 2024
Author(s): Agam Bansal, Aravinda Nanjundappa, Daniel Raymond, Lee Kirksey, Umesh N. Khot

Existing studies have illustrated that the coronavirus disease 2019 (COVID-19) infection is an independent risk factor for pulmonary embolism (PE) [1–4]. However, longitudinal trends in incidence of... more

Histopathological necrotizing vasculitis predicts severe flare of eosinophilic granulomatosis with polyangiitis

31 January 2024
Author(s): Eisuke Takamasu, Naoto Yokogawa, Haruka Okada, Ryo Morishima, Kota Shimada

Dear Editor, eosinophilic granulomatosis with polyangiitis (EGPA) is histologically defined by eosinophil-rich, necrotizing granulomatous inflammation primarily involving the respiratory tract along... more

Difficult to treat rheumatoid arthritis: Sequential therapy with different personalized biological targets could be an option

31 January 2024
Author(s): Elisa Gremese, Dario Bruno, György Nagy, Gianfranco Ferraccioli

Difficult to treat (D2T) rheumatoid arthritis (RA) is considered a clinical setting that physicians already label as very complicated to address from a therapeutic point of view for various reasons [... more

Prognostic value of paradoxical pulsation after acute anterior myocardial infarction

27 January 2024
Author(s): Bing-Hua Chen, Hui Tang, Dong-Aolei An, Jun Pu, Lian-Ming Wu

After acute anterior myocardial infarction, most patients displayed paradoxical pulsation (the paradoxical expansion of left ventricular infarct segments), which is easily complicated by early... more

Previously undiagnosed asymptomatic peripheral arterial disease in patients undergoing coronary angiography

23 January 2024
Author(s): Sohaib Ashraf, Amir Shahbaz, Maryam Ashraf, Wasim Ibrahim, Qazi Abdul Saboor

Atherosclerosis plays a significant role in developing coronary artery disease (CAD), peripheral artery disease (PAD), and cerebrovascular disease. Atherosclerotic plaque rupture provokes... more

Bone infarction: A rare complication of essential thrombocytosis with JAK2-V617F mutation

19 January 2024
Author(s): Yun Yang, Yanjun Ren, Kaining Zhang, Meng Chen, Changjun Chen

We read with great interest the article by Yang et al., published in the European Journal of Internal Medicine [1]. We appreciate their great work. In addition to the finding that JAK2-V617F-mutated... more

Treatment with direct oral anticoagulants (DOACs) and secondary prophylaxis in patients affected by multiple episodes of superficial venous thrombosis

19 January 2024
Author(s): Alessandro Laganà, Silvia Sorella, Ludovica Fucci, Angelo Genoese, Antonio Chistolini

Superficial vein thrombosis (SVT) describes partial or total thrombotic lumen obstruction of a superficial vein and inflammatory alterations of the affected vessel wall [1]. The precise incidence of... more

Thrombocytopenia and bleeding events in patients with venous thromboembolism

17 January 2024
Author(s): Shinya Ito, Moriaki Inoko, Yugo Yamashita, Takeshi Morimoto, Takeshi Kimura, COMMAND VTE Registry-2 Investigators

Thrombocytopenia is a prevalent blood abnormality, especially in elderly patients or those with cancer [1], and could increase the risk of anticoagulation-associated bleeding. However, there is a... more

Imaging of lung structure destruction for predictive diagnosing acute exacerbation of chronic obstructive lung disease complicated with pulmonary thromboembolism or pulmonary thrombosis in situ

16 January 2024
Author(s): Dawen Wu, Shimou Chen, Yunchang Pan, Rongzhang Liang, Chaosheng Deng, COPD and PTE Study Group

Chronic obstructive lung disease (COPD) is an independent risk factor for pulmonary thromboembolism (PTE), which often originates from deep vein thrombosis (DVT) and is a common comorbidity [1].... more

Machine learning models for the early prediction of ventilator-associated pneumonia

30 December 2023
Author(s): Liqi Li

We read with interest the article by Frondelius et al. entitled ‘Early prediction of ventilator-associated pneumonia with machine learning models: A systematic review and meta-analysis of prediction... more

Combined guidance of fluoroscopy and transthoracic echocardiography for endomyocardial biopsy

30 December 2023
Author(s): Yin-Jian Yang, Fan Guo, Lu-Hong Qiu, Xi-Qi Xu, Zhi-Cheng Jing

Endomyocardial biopsy (EMB) is important in revealing the aetiology of cardiac disorders for individuals in whom non-invasive approaches are insufficient to gather a correct diagnosis, as well as in... more

Don't ignore the internists; Who do you think holds the holy grail?

29 December 2023
Author(s): Oğuz Abdullah Uyaroğlu

Recently a new paradigm, cardiovascular-kidney-metabolic (CKM) syndrome, has been defined by the American Heart Association (AHA) as a health problem due to connections among diabetes, kidney disease... more

Original Article

Osteonecrosis risk after steroids-related treatment of COVID-19 is not negligible: A cross sectional study

27 January 2024
Author(s): Antonios A. Koutalos, Alexandros Koskiniotis, Christos Rountas, Efstathios Konstantinou, Sarah Georgiadou, Aggelos Stefos, Nikolaos K. Gatselis, George N. Dalekos, Konstantinos N. Malizos

Osteonecrosis is a common complication after steroid treatment for various etiologies more frequently affecting the hip, but also the humeral head, the knee, and the ankle joints [1]. Due to the... more

Transition of management strategies and long-term outcomes in cancer-associated venous thromboembolism from the warfarin era to the direct oral anticoagulant era

25 January 2024
Author(s): Ryuki Chatani, Yugo Yamashita, Takeshi Morimoto, Kazuhisa Kaneda, Kazunori Mushiake, Kazushige Kadota, Yuji Nishimoto, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Shuhei Tsuji, Maki Oi, Takeshi Kimura, COMMAND VTE Registry-2 Investigators

Cancer remains a progressive disease with a high mortality despite of multidisciplinary treatment. However, many patients with cancer have recently been living longer owing to advancement in early... more

Post-cardiac injury syndrome and pericardial effusion recurrence after pericardial effusion drainage in chronic idiopathic pericardial effusion

22 January 2024
Author(s): Edoardo Conte, Silvia Tamanini, Emanuele Bizzi, Silvia Maestroni, Davide Cumetti, Maria Laura Novembre, Gianfranco Lauri, Cecilia Agalbato, Alessia Dalla Cia, Pasquale Paolisso, Gianluca Pontone, Mauro Pepi, Daniele Andreini, Massimo Imazio, George Lazaros, Alberto Benetti, Antonio Brucato

Chronic pericardial effusion in the absence of pericardial inflammation often represents both a diagnostic and management dilemma. Although pericardial effusion drainage should be promptly performed... more

Genetic heterogeneity of familial hypercholesterolaemia in two populations from two different countries

19 January 2024
Author(s): Asiiat Alieva, Alessia Di Costanzo, Marta Gazzotti, Olga Reutova, Elena Usova, Viktoria Bakaleiko, Marcello Arca, Laura D'Erasmo, Fabio Pellegatta, Federica Galimberti, Elena Olmastroni, Alberico L Catapano, Manuela Casula

Familial hypercholesterolemia (FH) (MONDO:0007750) is a genetically determined monogenic disorder of predominantly autosomal dominant inheritance, which leads to a significant increase in low-density... more

Deferring diagnostic evaluation for suspected deep venous thrombosis using a single dose of anticoagulant: Real-world data from a regionwide care pathway

26 December 2023
Author(s): Inge H.Y. Luu, Guy J.M. Mostard, Dominique van Mil, Marlon H.W. van Berlo, Marc B.I. Lobbes, Kemal Külcü, Hugo ten Cate, Jos Peeters, Jan Palmen, Jacqueline Buijs, Kon-Siong G. Jie, Roel J.W. van Kampen, Daan J.L. van Twist

Timely diagnosis and treatment of deep venous thrombosis (DVT) are crucial to prevent potential life-threatening complications, such as pulmonary embolism (PE). As DVT cannot be reliably excluded... more

Intimate partner violence as a risk factor for venous thromboembolism in women on combined oral contraceptives: An international matched case-control study

21 December 2023
Author(s): Mathias Chéa, Chloé Bourguignon, Sylvie Bouvier, Eva Nouvellon, Jeremy Laurent, Antonia Perez-Martin, Eve Mousty, Sylvie Ripart, Mariya Gennadevna Nikolaeva, Jamilya Khizroeva, Victoria Bitsadze, Alexander Makatsariya, Jean-Christophe Gris

Venous thromboembolism (VTE), deep vein thrombosis (DVT) and/or pulmonary embolism (PE) is a rare event in women of childbearing age, affecting 2–10/10,000 persons per year [1]. Exogenous sex... more

Thyroid and adrenal incidentalomas on chest CT: Prevalence, diagnostic work-up and outcomes in a cohort of COVID-19 suspected patients

20 December 2023
Author(s): Jeresa I.A. Willems, Roderick F.A. Tummers-de Lind van Wijngaarden, Ivo J.M. Dubelaar, Martijn D. De Kruif, Math P.G. Leers, Inge H.Y. Luu, Robin P. Peeters, Daan J.L. van Twist

Thyroid and adrenal incidentalomas are commonly detected on computed tomography (CT) imaging. Due to the increased use of advanced CT imaging prevalence rates are still rising, leading to an ‘... more

Adherence to an integrated care pathway for stroke is associated with lower risk of major cardiovascular events: A report from the Athens Stroke Registry

15 December 2023
Author(s): Dimitrios Sagris, Gregory Υ Η Lip, Eleni Korompoki, George Ntaios, Konstantinos Vemmos

Despite improvements in overall stroke survival, patients surviving an ischaemic stroke are at increased risk of cardiovascular complications, both in the acute and chronic phase, and one-third of... more

Kidney function and other associated factors of sarcopenia in community-dwelling older adults: The SCOPE study

15 December 2023
Author(s): Rafael Moreno-González, Josep Maria Cruzado, Andrea Corsonello, Paolo Fabbietti, Lisanne Tap, Francesco Mattace-Raso, Johan Ärnlöv, Axel C. Carlsson, Agnieszka Guligowska, Tomasz Kostka, Rada Artzi-Medvedik, Itshak Melzer, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Robert Kob, Cornel Sieber, Fabrizia Lattanzio, Francesc Formiga, SCOPE investigators

Sarcopenia has been drawing growing attention in recent years, with a rapidly increasing number of research studies being performed in this field. The establishment of an International Classification... more

Features of immune mediated diseases in JAK2 (V617F)-positive myeloproliferative neoplasms and the potential therapeutic role of JAK inhibitors

2 December 2023
Author(s): Carmen Álvarez-Reguera, Diana Prieto-Peña, Alba Herrero-Morant, Lara Sánchez-Bilbao, Ana Batlle-López, Sara Fernández-Luis, Nerea Paz-Gandiaga, Ricardo Blanco

The Janus Kinase (JAK) 2 (V617F) mutation is the most frequently detected in myeloproliferative neoplasms (MPN). JAK2(V617F) mutation displays a pro-inflammatory phenotype that may be associated to a... more

Chronic thromboembolic pulmonary disease: Association with exercise-induced pulmonary hypertension and right ventricle adaptation over time

1 December 2023
Author(s): Rosalinda Madonna, Mattia Alberti, Filippo Biondi, Riccardo Morganti, Roberto Badagliacca, Carmine Dario Vizza, Raffaele De Caterina

Chronic thromboembolic pulmonary disease (CTEPD) [1] is a newly described disease entity belonging to a broader group of diseases affecting the pulmonary arterial vasculature as a result of PE [1,2... more

Relation between high-sensitivity troponin I serum levels and myocardial ischemia in patients with suspected chronic coronary syndrome: The RESET-MI study

23 November 2023
Author(s): Antonio De Vita, Isabella Bruno, Silvia Baroni, Giacomo Moretti, Federica Tempestini, Alessandro Telesca, Saverio Tremamunno, Tamara Felici, Alfonso Verrillo, Valeria Tempesta, Vanessa Feudo, Priscilla Lamendola, Giovanna Liuzzo, Filippo Crea, Alessandro Giordano, Gaetano Antonio Lanza

The detection of increased serum levels of cardiac troponins in a clinical context of acute myocardial ischemia is a crucial finding for the diagnosis of acute myocardial infarction (AMI) [1,2].... more

Muscularity and adiposity are differently associated with inflammatory and nutritional biomarkers among patients on hemodialysis and peritoneal dialysis

18 November 2023
Author(s): Alessio Molfino, Giovanni Imbimbo, Orietta Picconi, Lida Tartaglione, Maria Ida Amabile, Silvia Lai

Changes in body composition, in particular in terms of distribution and quantity of adiposity and low muscularity, have been frequently observed in end-stage renal disease (ESRD) and associated with... more

Long non-coding RNAs H19 and NKILA are associated with the risk of death and lacunar stroke in the elderly population

18 November 2023
Author(s): Tetiana Lapikova-Bryhinska, Stefano Ministrini, Yustina M. Puspitasari, Simon Kraler, Shafeeq Ahmed Mohamed, Sarah Costantino, Francesco Paneni, Michael Khetsuriani, Susan Bengs, Luca Liberale, Fabrizio Montecucco, Wolfgang Krampla, Peter Riederer, Margareta Hinterberger, Peter Fischer, Thomas F. Lüscher, Edna Grünblatt, Alexander Akhmedov, Giovanni G. Camici

Aging is a multifaceted biological process characterized by a progressive decline in physiological function and increased vulnerability to various diseases [1]. It is associated with multiple... more

Prognostic role of mitral regurgitation in patients with advanced heart failure

17 November 2023
Author(s): Matteo Pagnesi, Filippo Calì, Mauro Chiarito, Davide Stolfo, Luca Baldetti, Carlo M. Lombardi, Daniela Tomasoni, Ferdinando Loiacono, Marta Maccallini, Alessandro Villaschi, Daniele Cocianni, Maria Perotto, Adriaan A. Voors, Daniela Pini, Marco Metra, Marianna Adamo, HELP-HF Registry investigators

Mitral regurgitation (MR) is the most common valvular heart disease in patients with heart failure (HF) [1]. Left ventricular remodeling, left atrial enlargement, and cardiac dyssynchrony leading to... more

Risk of subclinical atherosclerosis in primary Sjogren's syndrome: A systematic review and meta-analysis

15 November 2023
Author(s): Paschalis Karakasis, Dimitrios Patoulias, Konstantinos Pamporis, Panagiotis Stachteas, Eleftheria Lefkou, Konstantinos I. Bougioukas, Theodoros Dimitroulas, Nikolaos Fragakis

Cardiovascular disease (CVD) in systemic autoimmune disorders often goes unnoticed until a clinical event occurs. Given the lack of disease-specific prediction scores, the CVD risk stratification... more

Calprotectin serum levels on admission and during follow-up predict severity and outcome of patients with COVID-19: A prospective study

10 November 2023
Author(s): Nikolaos K. Gatselis, Aggeliki Lyberopoulou, Vasiliki Lygoura, George Giannoulis, Anna Samakidou, Antonia Vaiou, Katerina Antoniou, Katerina Triantafyllou, Aggelos Stefos, Sarah Georgiadou, Dimitrios Sagris, Dafni Sveroni, Stella Gabeta, George Ntaios, Gary L. Norman, George N. Dalekos

Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by a broad spectrum of clinical manifestations [1]. SARS-CoV-2... more

Prognostic significance of the wall to lumen ratio of retinal arterioles evaluated by adaptive optics

31 October 2023
Author(s): Carolina De Ciuceis, Claudia Agabiti Rosei, Paolo Malerba, Claudia Rossini, Matteo Nardin, Giulia Chiarini, Francesca Famà, Matteo Lemoli, Mattia Baresi, Alina Petelca, Chiara Bortoluzzi, Enzo Porteri, Massimo Salvetti, Maria Lorenza Muiesan, Enrico Agabiti Rosei, Damiano Rizzoni

The main characteristic of essential hypertension is the increase in peripheral vascular resistance to blood flow, located mostly in small arteries with a lumen diameter of 100 to 350 μm and in... more

ECG/echo indexes in the diagnostic approach to amyloid cardiomyopathy: A head-to-head comparison from the AC-TIVE study

17 October 2023
Author(s): Linda Pagura, Aldostefano Porcari, Matteo Cameli, Elena Biagini, Marco Canepa, Lia Crotti, Massimo Imazio, Cinzia Forleo, Rita Pavasini, Giuseppe Limongelli, Stefano Perlini, Marco Metra, Giuseppe Boriani, Michele Emdin, Gianfranco Sinagra, Marco Merlo, ACTIVE study group

Thickened left ventricle (LV) is the hallmark of amyloid cardiomyopathy (AC) and results from progressive amyloid deposition in the myocardial extracellular space rather than myocyte hypertrophy [1... more

Review Article

Dietary and pharmacological treatment in patients with metabolic-dysfunction associated steatotic liver disease

22 January 2024
Author(s): Angelo Armandi, Elisabetta Bugianesi

Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease, is a spectrum of liver injury characterized by increased hepatocellular fat... more

Non-invasive testing and risk-stratification in patients with MASLD

20 January 2024
Author(s): Mirko Zoncapè, Antonio Liguori, Emmanuel A. Tsochatzis

The development and validation of non-invasive fibrosis tests (NITs) has changed clinical practice in Hepatology over the last 15 years. Metabolic associated steatotic liver disease (MASLD), formerly... more

Resistant hypertension: Diagnosis, evaluation, and treatment practical approach

15 January 2024
Author(s): Roberto Parodi, Laura Brandani, César Romero, Manuel Klein

Our learning objectives are to be able to identify patients with resistant hypertension (RH) in primary care practice, know the clinical and phenotypic characteristics of this group of patients, and... more

Breakthrough advances enhancing care in ATTR amyloid cardiomyopathy

5 January 2024
Author(s): Aldostefano Porcari, Gianfranco Sinagra, Julian D Gillmore, Marianna Fontana, Philip N Hawkins

Transthyretin amyloid cardiomyopathy (ATTR-CM) has been traditionally considered a rare and inexorably fatal condition. ATTR-CM now is an increasingly recognized cause of heart failure (HF) and... more

Enduring echoes: Post-infectious long-term changes in innate immunity

21 December 2023
Author(s): Elisabeth A. Dulfer, Leo A.B. Joosten, Mihai G. Netea

The human immune system is one of the main host defence mechanism against infections, initiating a complex response when confronted with pathogenic invaders. This response involves pathogen... more

Natural history of metabolic dysfunction-associated steatotic liver disease

6 November 2023
Author(s): Vasileios Lekakis, George V. Papatheodoridis

Metabolic dysfunction-associated steatotic liver disease (MASLD) has been the term for non-alcoholic fatty liver disease (NAFLD) since June 2023 and will be used instead of NAFLD throughout this... more


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