November 2022

31 Articles

No Section

The Role of Adenosine and Its Degradation Enzymes – Adenosinedeaminase and Adenosinekinase in Pathogenesis of Vasovagal Syncope

5 September 2022
Author(s): Zora Lazurova, Peter Mitro, Marcela Popovnakova

Syncope is defined as a transient loss of consciousness with spontaneous recovery, typically accompanied by the loss of postural tone, that is caused by an intermittent hypoperfusion of the brain.... more


IgA nephropathy and acute renal diseases and disorders: A puzzle waiting to be solved

7 October 2022
Author(s): Loreto Gesualdo, Fabio Sallustio

IgA nephropathy (IgAN), the most frequent primary glomerulonephritis worldwide, may present with several clinical manifestations and may develop into end stage kidney disease in 30–40% of cases.

Venous thromboembolism in pancreatic cancer patients: Time to consider routine thromboprophylaxis?

28 September 2022
Author(s): Marcello Di Nisio, Nicola Potere, Ettore Porreca

Venous thromboembolism (VTE) represents a relatively common complication in patients with cancer and is associated with considerable morbidity and mortality as well as resources utilization and... more

COVID vaccine-induced immune thrombotic thrombocytopenia: Rare but relevant

17 September 2022
Author(s): Andreas Greinacher

Marietta, Coluccio, and Luppi present a comprehensive review of the current understanding and hypotheses on the mechanisms of vaccine-induced immune thrombotic thrombocytopenia (VITT) [1]. Although... more

Systematic screening of atrial fibrillation works, but is this our current priority?

9 September 2022
Author(s): Mario Bo, Roberto Presta, Enrico Brunetti

Prevalence and incidence of atrial fibrillation (AF) increase with age, making it the most common cardiac arrhythmia in older people and a growing burden for healthcare services in developed... more

Internal Medicine Flashcard

A red herring electrocardiogram

12 August 2022
Author(s): Anish Kapil

A gentleman in his 50s presented with atypical chest pain for the last 3 months. He had no prior comorbidities. Cardiovascular system examination was unremarkable. Baseline electrocardiogram is shown... more

“Milking” the way to diagnosis

11 August 2022
Author(s): Andreína Vasconcelos, Bárbara Rodrigues, Pedro Gonçalo Ferreira

A 43-year-old non-smoker man presented to the emergency department with exertional dyspnoea and left pleuritic pain lasting for 3 days. He denied fever and cough and described a history of pulmonary... more

Letter to the Editor

The RECOVERY trial: An analysis and reflection two years on

26 September 2022
Author(s): Aaron Duncan, Dzufar Halim, Khalid El Kholy

The RECOVERY trial led the way in scientific advances during the initial stages of the coronavirus disease 2019 (COVID-19) pandemic with regards to changing clinical practice [1,2]. This was a result... more

Might midodrine be useful in patients with decompensated and worsening chronic heart failure? Author's reply

18 September 2022
Author(s): Gianfranco Sinagra, Enrico Fabris

We thank Fernández–Fernández et al. [1] for their interest in our manuscript [2] and for raising the question about the potential use of midodrine in patients with decompensated and worsening chronic... more

Pitfalls for blood culture diagnostic stewardship. Author's Reply

10 September 2022
Author(s): Sarah Dräger, Michael Osthoff

community acquired pneumonia

Might midodrine be useful in patients with decompensated and worsening chronic heart failure?

30 August 2022
Author(s): Francisco José Fernández-Fernández, Eugenia Ameneiros-Lago, Raquel Sardina-Ferreiro

We read with interest the excellent article “ Ultrafiltration in decompensated heart failure: Is time to look forward?” by Sinagra and Fabris [1]. As the authors point out, guidelines recommend that... more

COVID-19 vaccines effect on blood pressure

22 August 2022
Author(s): Marco Simonini, Maria Giovanna Scarale, Francesca Tunesi, Paolo Manunta, Chiara Lanzani, Multidisciplinary Epidemiological Research Team Study Group

Recently, with the SARS-CoV-2 vaccination campaign progress, evidence of possible alteration of blood pressure (BP) associated with vaccination has increased [1]. BP changes occurred in two... more

Inhaled triple therapy in individuals with Chronic Obstructive Pulmonary Disease and indications of pulmonary rehabilitation

15 August 2022
Author(s): Michele Vitacca, Mara Paneroni, Antonio Spanevello, Piero Ceriana, Nicolino Ambrosino

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease, characterized by persistent and progressive airflow limitation, worsening reduced exercise capacity, and health-... more

Knowing the new Omicron BA.2.75 variant (‘Centaurus’): A simulation study

15 August 2022
Author(s): Martina Zappa, Paolo Verdecchia, Fabio Angeli

Dear Editor,

Pitfalls for blood culture diagnostic stewardship

1 August 2022
Author(s): Hiroshi Ito

According to Dräger S and colleagues [1], about half of the blood culture tests were not indicated according to the guidelines in a Swiss university hospital. They concluded that implementing a... more

Influenza vaccine among patients with coronary artery disease

1 August 2022
Author(s): Hamed Mohamed, Al-Azizi Karim, Jneid Hani, Khalife Wissam, Elbadawi Ayman, on behalf of INFCAD

Infection has been proposed to be a possible risk factor for the process of atherosclerosis [1]. Influenza virus infection has been temporally associated with cardiovascular morbidity and mortality,... more

Alzheimer's disease and increasing the uptake of influenza vaccination

29 July 2022
Author(s): Ami Schattner

Despite unequivocal research and guidelines, the uptake of influenza vaccination remains markedly suboptimal even among older adults whose risk of substantial influenza-associated morbidity and... more

Gadolinium deposition disease (GDD): Does the missing link exist? -A suggested pathologic model

18 July 2022
Author(s): Ingrid B. Boehm

Initially, gadolinium-based contrast agents (GBCAs) have been considered as inert compounds without any potential to induce adverse side effects. Now, more than three decades after their introduction... more

Causal effect of non-alcoholic fatty liver disease on atrial fibrillation

15 July 2022
Author(s): Jun Chen, Ziwei Mei, Yimin Wang, Yijie Chen, Qiang Liu

Non-alcoholic fatty liver disease (NAFLD) includes a range of liver pathologies based on non-alcoholic fatty liver, defined by the presence of fat accumulation in more than 5% of hepatocytes by non-... more

Olmesartan-induced enteropathy: More than one entity?

4 July 2022
Author(s): Giuseppe Famularo, Andrea Aglitti, Laura Magrini

Dear Editor,

Original Article

Cancer in patients with heart failure: Incidence, risk factors and prognostic impact

18 September 2022
Author(s): Marta Sagastagoitia-Fornie, Eduardo Barge-Caballero, Gonzalo Barge-Caballero, David Couto-Mallón, María J. Paniagua-Martín, Daniel Enríquez-Vázquez, Paula Blanco-Canosa, Zulaika Grille-Cancela, Manuel Jiménez-Navarro, Javier Muñiz, José M. Vázquez-Rodríguez, María G. Crespo-Leiro

Heart Failure (HF) and cancer are the main causes of morbidity and mortality in developed countries [1], and their prevalence is increasing due to ageing of the population. Therefore, patients with... more

Multivessel vs. culprit-only percutaneous coronary intervention strategy in older adults with acute myocardial infarction

13 September 2022
Author(s): Claudio Montalto, Nuccia Morici, Aung Myat, Gabriele Crimi, Giuseppe De Luca, Irene Bossi, Adam de Belder, Stefano Savonitto, Stefano De Servi

The optima revascularization strategy for senior patients admitted with acute myocardial infarction (AMI) in the context of multivessel coronary artery disease (MVCAD) remains unclear. We aimed to... more

Epidemiology and outcome of anaerobic bacteremia in a tertiary hospital

31 August 2022
Author(s): Yasmin Zouggari, Christophe Lelubre, Salah Eddine Lali, Soraya Cherifi

Anaerobic bacteria make up a large part of the human bacterial flora by colonizing the skin and mucous membranes. However, they can also be opportunistic pathogens and cause serious infections in... more

Adherence to the “Atrial fibrillation Better Care” (ABC) pathway in patients with atrial fibrillation and cancer: A report from the ESC-EHRA EURObservational Research Programme in atrial fibrillation (EORP-AF) General Long-Term Registry

23 August 2022
Author(s): Marco Vitolo, Marco Proietti, Vincenzo L. Malavasi, Niccolo’ Bonini, Giulio Francesco Romiti, Jacopo F. Imberti, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S. Potpara, Gheorghe-Andrei Dan, Zbigniew Kalarus, Aldo Pietro Maggioni, Deirdre A. Lane, Gregory Y H Lip, Giuseppe Boriani, ESC-EHRA EORP-AF Long-Term General Registry Investigators

In recent years, the Atrial Fibrillation Better Care (ABC) pathway has been proposed as a holistic and structured approach to atrial fibrillation (AF) management [1,2]. The ABC pathway is based on... more

Angiographic and clinical outcome of SARS-CoV-2 positive patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: A collaborative, individual patient data meta-analysis of six registry-based studies

17 August 2022
Author(s): Giuseppe De Luca, Angelo Silverio, Monica Verdoia, Zbigniew Siudak, Tomasz Tokarek, Thomas A. Kite, Anthony H. Gershlick, Oriol Rodriguez-Leor, Belen Cid-Alvarez, Daniel A. Jones, Krishnaraj S. Rathod, José M. Montero-Cabezas, Alfonso Jurado-Roman, Matteo Nardin, Gennaro Galasso

Coronavirus disease 2019 (COVID-19) has strongly impacted on worldwide healthcare systems with significant resources diverted to deal with this unforeseeable modern pandemic. Several reports have... more

Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials

8 August 2022
Author(s): Ayman Elbadawi, Ramy Sedhom, Mohamed Gad, Mohamed Hamed, Amr Elwagdy, Amr F. Barakat, Umair Khalid, Mamas A. Mamas, Yochai Birnbaum, Islam Y. Elgendy, Hani Jneid

Atrial fibrillation (AF) is a prevalent and common treatable risk factor for ischemic stroke [1]. The prevalence of AF increases with aging. It has been estimated that the lifetime risk of AF is 1 in... more

Incidence, risk factors, and evolution of venous thromboembolic events in patients diagnosed with pancreatic carcinoma and treated with chemotherapy on an outpatient basis

2 August 2022
Author(s): Silvia García Adrián, Adán Rodríguez González, Eva Martínez de Castro, Vanessa Pachón Olmos, Laura Ortega Morán, Purificación Martínez del Prado, Mercedes Salgado Fernández, José David Cumplido Burón, Ignacio García Escobar, Joaquina Martínez Galán, Ana Isabel Ferrer Pérez, Fernando Neria, Diego Cacho Lavin, Borja López de San Vicente Hernández, Paula Jiménez-Fonseca, Andrés J. Muñoz Martín

Venous thromboembolic disease is considered one of the leading causes of morbi-mortality [1,2]. in oncological patients. Cancer multiplies the risk of thromboembolic events 6- or 7-fold compared to... more

IgA nephropathy with acute kidney disease: Characteristics, prognosis, and causes

28 June 2022
Author(s): Xutong Wang, Zuishuang Guo, Bo Huang, Minhua Xie, Jingjing Ren, Yuze Zhu, Haonan Guo, Yongli Wang, Dan Yu, Junjun Zhang, Linqi Zhang

The clinical manifestations and prognosis of IgA nephropathy (IgAN) are diverse. Some patients may present with kidney dysfunction lasting shorter than 3 months and meet the acute kidney disease (AKD... more

Review Article

Potential mechanisms of vaccine-induced thrombosis

8 August 2022
Author(s): Marco Marietta, Valeria Coluccio, Mario Luppi

COVID-19 has so deeply impacted in every aspect of the human existence that most of us in the next years will reconsider its life as “before” and “after” the pandemic. At the time of writing, more... more

Mycobacterium marinum: A brief update for clinical purposes

19 July 2022
Author(s): Diana Canetti, Niccolò Riccardi, Roberta Maria Antonello, Silvia Nozza, Giovanni Sotgiu

Incident cases of non-tuberculous mycobacteria (NTM) are steadily increasing worldwide [1]. Among NTM, Mycobacterium marinum (M. marinum) is one of the causes of extrapulmonary mycobacterial... more

The COVID-19 pandemic – How many times were we warned before?

17 July 2022
Author(s): Naim Mahroum, Isa Seida, Sevval Nil Esirgün, Nicola Luigi Bragazzi

As the pandemic of coronavirus disease 2019 (COVID-19) continues to emerge worldwide with no country being spared [1], scientists and researchers are relentlessly looking for the origin of SARS-CoV-2... more


Stay informed on our latest news!


This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.