October 2018

25 Articles

No Section

Indoor air pollution exposure effects on lung and cardiovascular health in the High Himalayas, Nepal: An observational study

31 October 2018
Author(s): Lorenza Pratali, Angela Marinoni, Annalisa Cogo, Kristian Ujka, Stefania Gilardoni, Eva Bernardi, Paolo Bonasoni, Rosa Maria Bruno, Luca Bastiani, Elisa Vuillermoz, Paolo Sdringola, Sandro Fuzzi

Exposure to indoor biomass fuel smoke is associated with increased morbidity and mortality. The aim of this study is to evaluate the association between exposure to indoor biomass burning and early... more

The new frontiers of rehabilitation medicine in people with chronic disabling illnesses

30 October 2018
Author(s): Domenico Scrutinio, Anna Giardini, Luca Chiovato, Antonio Spanevello, Michele Vitacca, Mario Melazzini, Gianni Giorgi

Because of the demographic shift and the increased proportion of patients surviving acute critical illnesses, the number of people living with severely disabling chronic diseases and, consequently,... more

Prevalence, predictors and clinical implications of prolonged corrected QT in elderly patients with dementia and suspected syncope

25 October 2018
Author(s): Mario Bo, Alice Ceccofiglio, Chiara Mussi, Giuseppe Bellelli, Franco Nicosia, Daniela Riccio, Anna M. Martone, Assunta Langellotto, Elisabetta Tonon, Gianni Tava, Virginia Boccardi, Pasquale Abete, Michela Tibaldi, Maria L. Aurucci, Gianfranco Fonte, Yolanda Falcone, Andrea Ungar

Long QT and use of QT-prolonging drugs are common among older patients receiving polytherapies, but real-world evidence on their impact in clinical practice is controversial. We investigated... more

Assessment of the clinical relevance of pharmacists' interventions performed during medication review in a rheumatology ward

25 October 2018
Author(s): Anne-Laure Yailian, Elsa Revel, Cléa Tardy, Aurélie Fontana, Charline Estublier, Evelyne Decullier, Claude Dussart, Roland Chapurlat, Christine Pivot, Audrey Janoly-Dumenil

Pharmacists contribute to reduce the number of medication errors during medication review. Nevertheless, few French studies report the potential clinical impact of pharmacists' interventions... more

Non-invasive positive pressure ventilation in pneumonia outside Intensive Care Unit: An Italian multicenter observational study

24 October 2018
Author(s): Anna Maria Brambilla, Elena Prina, Giovanni Ferrari, Viviana Bozzano, Rodolfo Ferrari, Paolo Groff, Giuseppina Petrelli, Raffaele Scala, Fabio Causin, Paola Noto, Emanuela Bresciani, Antonio Voza, Stefano Aliberti, Roberto Cosentini, 3P study group

Non-Invasive Ventilation (NIV) represents a standard of care to treat some acute respiratory failure (ARF). Data on its use in pneumonia are lacking, especially in a setting outside the Intensive... more

Geographical pattern of chronic liver diseases in Italy: Results from two pooled national surveys

22 October 2018
Author(s): Tommaso Stroffolini, Evangelista Sagnelli, Caterina Sagnelli, Antonina Smedile, Filomena Morisco, Nicola Coppola, Caterina Furlan, Piero Luigi Almasio

The information on the geographical characteristics of chronic liver diseases (CLD) in Italy is out-dated.

Massive cardiac and pulmonary thrombi after cardiac surgery

5 October 2018
Author(s): Anke Van Mellaert, Axel Derwa, Jan De Raet

A 32-year-old obese male with bicuspid aortic valve and severely dilated ascending aorta (59.5 mm) underwent hemi-arch aortic replacement and valvuloplasty on cardiopulmonary bypass. Due to... more

Internal Medicine Flashcard

Papulopustules and paronychia in a lung carcinoma

5 October 2018
Author(s): Vishal Thakur, Manju Daroach, Muthu Sendhil Kumaran

A 61 years old male was referred from pulmonary medicine department with 2- week history of acneiform lesions over face and upper back, with associated complaints of pain in proximal nail folds of... more

Worsening alopecia in an elderly woman

4 October 2018
Author(s): Simonetta Piana, Caterina Longo, Riccardo Valli

A woman in her 70s presented with a worsening alopecia and multiple erythematous plaques involving the scalp, the frontal area and the eyebrows (Fig. 1A and B). Pruritus was a significant feature. A... more

Bilateral hand edema: simply nothing or nothing simple?

4 October 2018
Author(s): J. Poblet Florentín, J. Modesto Dos Santos, F. Javier Anniccherico

An 83-year-old Caucasian man presented to the author's hospital for study of hand swelling. The patient presented a bilateral hand dorsal pitting edema (Fig. 1) of one month of evolution with mild... more

An unusual cause of intracranial hemorrhage

4 October 2018
Author(s): Yusaku Kajihara

A 39-year-old woman with no significant medical history was admitted in the emergency room with loss of consciousness. Computed tomography revealed right-sided putamen hemorrhage (Fig. 1, Panel A).... more

Letter to the Editor

Cannabis as a medicine. An update of the Italian reality

31 October 2018
Author(s): Oscar Corli, Enrico Davoli, Claudio Medana, Silvio Garattini, On behalf of the Conference Group

Cannabis and cannabinoids gained increasing attention for their possible clinical uses, as recently reported in a Special issue of this journal. The Mario Negri Institute recently organized a... more

Epidemiology of Clostridium difficile infection in Portugal: Experience at a tertiary care hospital

18 October 2018
Author(s): Sara Sintra, Filipe Taveira, Catarina Canha, Armando Carvalho, Adélia Simão

Clostridium difficile is the main cause of healthcare-associated diarrhoea. Its incidence, severity and relapse rates increased over the past two decades.

Comparison between specific and nonspecific assay in the evaluation of the anticoagulant effect of the Direct Oral Anticoagulants: Our experience in a cardiovascular hospital

12 October 2018
Author(s): Marco Prinzivalli, Graziella Sammarco, Benedetta Rampoldi, Elena Costa, Massimiliano M. Corsi Romanelli

The new generation of antithrombotic agents, known as Direct Oral Anticoagulants (DOACs), act on a single factor within the coagulation cascade. Although the monitoring of therapy is not necessary... more

Mortality and morbidity due to exposure to particulate matter related to drying Urmia Lake in the NW Iran

5 October 2018
Author(s): Amir Mohammadi, Maryam Faraji, Gea Oliveri Conti, Margherita Ferrante, Mohammad Miri

Combination of PM with heavy metals and different constituents related to Urmia Lake and PM from anthropogenic activities has been anticipated to exacerbate health impacts on 3,000,000 inhabitant in... more

Appropriateness of ordering serum angiotensin-converting enzyme during renin-angiotensin-aldosterone system inhibitor therapy

5 October 2018
Author(s): A. Betrains, P. Vermeersch, S. Vanderschueren

Sarcoidosis is a multisystem inflammatory disease of unknown etiology that manifests as non-caseating granulomas, predominantly in the lungs and intrathoracic lymph nodes, but possibly affecting any... more

Narrative Review

Venous carbon dioxide embolism during laparoscopic cholecystectomy a literature review

20 October 2018
Author(s): Kiki I.F. de Jong, Peter W. de Leeuw

Laparoscopy has become the procedure of choice for routine gallbladder removal. A serious complication of this technique is the occurrence of gas emboli due to insufflation. It is associated with a... more

Original Article

Validation of the BAP-65 score for prediction of in-hospital death or use of mechanical ventilation in patients presenting to the emergency department with an acute exacerbation of COPD: a retrospective multi-center study from the Italian Society of...

31 October 2018
Author(s): Federico Germini, Giacomo Veronese, Maura Marcucci, Daniele Coen, Deborah Ardemagni, Nicola Montano, Andrea Fabbri, the SIMEU Study Group

Exacerbations of chronic obstructive pulmonary disease (COPDE) frequently require hospitalizations, may necessitate of invasive mechanical ventilation (IMV), and are associated with a remarkable in-... more

Atrial fibrillation in patients with active malignancy and use of anticoagulants: Under-prescription but no adverse impact on all-cause mortality

29 October 2018
Author(s): Vincenzo Livio Malavasi, Elisa Fantecchi, Laura Gianolio, Francesca Pesce, Giuseppe Longo, Marco Marietta, Stefano Cascinu, Gregory Y.H. Lip, Giuseppe Boriani

Prescription of anticoagulants (ACs) in patients with cancer and atrial fibrillation (AF) is challenging and the impact on survival is not defined.In this study data prospectively collected in... more

Influence of potassium levels on one-year outcomes in elderly patients with acute heart failure

26 October 2018
Author(s): Francesc Formiga, David Chivite, Xavier Corbella, Alicia Conde-Martel, José Carlos Arévalo-Lorido, Joan Carles Trullàs, José Pérez Silvestre, Sara Carrascosa García, Luis Manzano, Manuel Montero-Pérez-Barquero, RICA investigators group

Abnormal serum potassium levels (K+) in patients with heart failure (HF) relate to worse prognosis. We evaluated whether admission K+ levels predict 1-year outcomes in elderly patients admitted for... more

Cardiac troponin T and NT-proBNP as diagnostic and prognostic biomarkers of primary cardiac involvement and disease severity in systemic sclerosis: A prospective study

23 October 2018
Author(s): Silvia Bosello, Giacomo De Luca, Giorgia Berardi, Giovanni Canestrari, Chiara de Waure, Francesca Augusta Gabrielli, Clara Di Mario, Franca Forni, Elisa Gremese, Gianfranco Ferraccioli

The aim of our study was to define the role of high-sensitive cardiac troponin T (hs-cTnT) and NT-proBNP in identifying Systemic Sclerosis (SSc) patients with cardiac involvement and at higher risk... more

Digoxin and prognosis of heart failure in older patients with preserved ejection fraction: Importance of heart rate. Results from an observational and multicenter study

22 October 2018
Author(s): Pau Llàcer, Julio Núñez, Antoni Bayés-Genís, Alicia Conde Martel, Yolanda Cabanes Hernández, Jesús Díez Manglano, Pablo Álvarez Rocha, Llanos Soler Rangel, Vicente Gómez Del Olmo, Luis Manzano, Manuel Montero Pérez-Barquero

The value of digoxin in heart failure (HF) remains controversial, particularly in patients with preserved ejection fraction (HFpEF). This study evaluated the 1-year risk of events after digoxin... more

Healthcare resource use in XALIA: A subgroup analysis of a non-interventional study of rivaroxaban versus standard anticoagulation for deep vein thrombosis

18 October 2018
Author(s): Lorenzo G. Mantovani, Sylvia Haas, Reinhold Kreutz, Kerstin Folkerts, Martin Gebel, Danja Monje, Jonas Schneider, Martin van Eickels, Kurtulus Sahin, Elizabeth Zell, Walter Ageno, Alexander G.G. Turpie

The non-interventional XALIA study compared the safety and effectiveness of rivaroxaban with standard anticoagulation for the treatment of venous thromboembolism in routine clinical practice. This... more

Association between heat stroke and ischemic heart disease: A national longitudinal cohort study in Taiwan

5 October 2018
Author(s): Min-Feng Tseng, Chu-Lin Chou, Chi-Hsiang Chung, Wu-Chien Chien, Ying-Kai Chen, Hsiu-Chien Yang, Pauling Chu

The purpose of this study is to determine the relationship between heat stroke and ischemic heart disease (IHD), in a nationwide population using a longitudinal approach. We retrospectively examined... more

Review Article

Extrahepatic autoimmunity in autoimmune liver disease

22 October 2018
Author(s): Annarosa Floreani, Sara De Martin, Maria Francesca Secchi, Nora Cazzagon

The most important autoimmune liver disease include: autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. In general, about one in three patients with an autoimmune... more


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