September 2016

23 Articles


Corrigendum to “Health care utilization of patients with multiple chronic diseases in The Netherlands: Differences and underlying factors” [Eur. J. Intern. Med. 26 (2015) 190–196]

24 September 2016
Author(s): Petra Hopman, Marianne J. Heins, Mieke Rijken, François G. Schellevis

The authors regret that the printed version of the above article contained a number of errors. A revised, correct and final version has been published online under the same title, with the following... more


Risk of ischemic stroke varies by ethnicity in patients with atrial fibrillation: A Swedish national cohort study

1 September 2016
Author(s): Jianguang Ji, Jan Sundquist, Kristina Sundquist

AF is an established independent risk factor for ischemic stroke as shown by many previous studies [1]. Anticoagulants are highly effective in reducing the risk of subsequent stroke in AF patients [2... more

Letter to the Editor

Return to sexual activity after myocardial infarction — An analysis of the level of knowledge in men undergoing cardiac rehabilitation

30 September 2016
Author(s): Dariusz Kałka, Jana Gebala, Michael Borecki, Witold Pilecki, Lesław Rusiecki

Sexual dysfunction is a typical complication of myocardial infarctions [1] and a high percentage of men limit or cease sexual activity following a myocardial infarction (MI) [2]. The potential... more

Critically ill patients at risk of invasive candidiasis: The “dilemma” of the best antifungal treatment strategy

17 September 2016
Author(s): Spinello Antinori, Laura Milazzo, Salvatore Sollima, Massimo Galli, Mario Corbellino

Dear Editor,

Comparison of the wells score with the revised Geneva score for assessing pretest probability of pulmonary embolism in hospitalized elderly patients

17 September 2016
Author(s): Yuxia Ma, Jiale Huang, Yuliang Wang, Tongwei Wu, Danxian Cai, Yanna Liu, Qijing Wu, Jialiang Hui, Yan Shi

With variable and nonspecific clinical manifestations [1], pulmonary embolism (PE) is associated with a mortality of approximately 30% and may cause sudden death within a few hours [2]. Therefore,... more

Validation of the qSOFA score for identification of septic patients: A retrospective study

15 September 2016
Author(s): Mikkel Brabrand, Ulrik Havshøj, Colin A. Graham

Identification of patients with sepsis is a difficult task. Until now, the Systemic Inflammatory Response Syndrome (SIRS) criteria have been recommended to identify patients with significant... more

Pulmonary hypertension in adults with congenital heart disease: First data from Latvian PAH registry

13 September 2016
Author(s): Andris Skride, Kristaps Sablinskis, Aivars Lejnieks, Ainars Rudzitis

Pulmonary arterial hypertension (PAH) is a common complication in patients with congenital heart disease (CHD), particularly in those with prominent left-to-right (systemic-to-pulmonary) shunt.... more

Response of first line treatment with corticosteroids in a population-based cohort of adults with primary immune thrombocytopenia

12 September 2016
Author(s): Henrik Frederiksen, Waleed Ghanima

Despite therapeutic achievements like rituximab and thrombopoeitin receptor agonists, corticosteroids remain the mainstay of first line treatment for immune thrombocytopenia (ITP) [1,2]. However,... more

Letter: The efficacy and safety of selective granulocyte and monocyte apheresis for inflammatory bowel disease: A meta-analysis

7 September 2016
Author(s): Zhenfei Liu, Xueliang Jiang, Chengcheng Sun

Selective granulocyte and monocyte apheresis (GMA) as a non-pharmacological option, has shown promising efficacy and higher safety in the treatment of patients with ulcerative colitis (UC). The GMA... more

Antineoplastic potential of metformin in colorectal cancer

6 September 2016
Author(s): Francisco José Fernández-Fernández

I read with interest the article “Colon neoplasia in patients with type 2 diabetes on metformin: A meta-analysis” by Rokkas and Portincasa [1]. As the authors note, the mechanisms underlying the... more

Difference in risk assessment for development of contrast-induced acute kidney injury using the MDRD versus CKD-EPI equations to estimate glomerular filtration rate

5 September 2016
Author(s): Paul A. Rootjes, Willem A. Bax, Erik L. Penne

Patients with kidney disease are at risk to develop acute kidney injury following administration of iodinated contrast. Depending on the estimated glomerular filtration rate (eGFR) and the presence... more

Additional clinical benefit independent of study result or trial arm allocation to participants in multi-center randomized controlled trials

3 September 2016
Author(s): Shaul Atar

Randomized controlled trials (RCT) are the definitive method for determining primary treatment efficacy and a crucial step in the development of novel therapies. Patients may participate in such... more

Influence of thyroid volume on the effect of methimazole in Japanese subjects with mild Graves' disease

3 September 2016
Author(s): Tomohiko Kimura, Michihiro Matsuki, Hideaki Kaneto, Tomoatsu Mune, Kohei Kaku

Methimazole (MMI) has been used in subjects with Graves' disease. Although in clinical medicine its starting dose was dependent on the judgment of each physician in charge, the Japan Thyroid... more

Letters to the Editor

Acute effect of dark chocolate on red blood cell distribution width

30 September 2016
Author(s): Martina Montagnana, Elisa Danese, Valentina Montolli, Gian Luca Salvagno, Giuseppe Lippi

Evidence accumulated over the past decades attests that moderate consumption of chocolate, especially dark chocolate, may produce favorable effects against cardiovascular disease [1]. Since... more

Narrative Review

Anemia management in cancer patients with chronic kidney disease

15 September 2016
Author(s): Andras T. Deak, Katharina Troppan, Alexander R. Rosenkranz

Anemia is a common complication of cancer and chronic kidney disease (CKD) associated with decreased physical performance as well as poor prognosis for life expectancy. Renal and cancer-induced... more

Original Article

Diagnostic performance of 320-slice computed tomography coronary angiography for symptomatic patients in clinical practice

29 September 2016
Author(s): Futoshi Yamanaka, Koki Shishido, Tomoki Ochiai, Noriaki Moriyama, Kazuki Tobita, Tomoyuki Tani, Kyosuke Furuhashi, Kazuya Sugitatsu, Daisuke Hachinohe, Tadashi Wada, Shingo Mizuno, Hidetaka Suenaga, Yutaka Tanaka, Masato Murakami, Junya Matsumi, Saeko Takahashi, Takeshi Akasaka, Shinji Tanaka, Shigeru Saito

Multi-slice computed tomography (MSCT) coronary angiography has been reported as an effective alternative to invasive conventional coronary angiography (CCA) for the diagnosis of coronary artery... more

Heart failure and anemia: Effects on prognostic variables

28 September 2016
Author(s): Gaia Cattadori, Piergiuseppe Agostoni, Ugo Corrà, Gianfranco Sinagra, Fabrizio Veglia, Elisabetta Salvioni, Alice Bonomi, Rocco La Gioia, Angela B. Scardovi, Alessandro Ferraironi, Michele Emdin, Marco Metra, Andrea Di Lenarda, Giuseppe Limongelli, Rosa Raimondo, Federica Re, Marco Guazzi, Romualdo Belardinelli, Gianfranco Parati, Sergio Caravita, Damiano Magrì, Carlo Lombardi, Maria Frigerio, Fabrizio Oliva, Davide Girola, Alessandro Mezzani, Stefania Farina, Massimo Mapelli, Domenico Scrutinio, Giuseppe Pacileo, Anna Apostolo, AnnaMaria Iorio, Stefania Paolillo, Pasquale Perrone Filardi, Paola Gargiulo, Maurizio Bussotti, Giovanni Marchese, Michele Correale, Roberto Badagliacca, Susanna Sciomer, Pietro Palermo, Mauro Contini, Pantaleo Giannuzzi, Elisa Battaia, Mariantonietta Cicoira, Francesco Clemenza, Chiara Minà, Simone Binno, Claudio Passino, Massimo F. Piepoli, on behalf of the MECKI score Research Group (appendix)

Anemia is frequent in heart failure (HF), and it is associated with higher mortality. The predictive power of established HF prognostic parameters in anemic HF patients is unknown.

Prospective study of the impact of diabetes mellitus newly diagnosed by glycated hemoglobin on outcomes in patients undergoing percutaneous coronary intervention

21 September 2016
Author(s): Muhammad Abu Tailakh, Michael Friger, Doron Zahger, Aviel Sidi, Efrat Mazor-Dray, Victor Novack

We sought to determine the prevalence of diabetes mellitus (DM) newly diagnosed by elevated glycated hemoglobin (HbA1c) in patients undergoing percutaneous coronary intervention (PCI) and its... more

Health care utilization of patients with multiple chronic diseases in the Netherlands: Differences and underlying factors

15 September 2016
Author(s): Petra Hopman, Marianne J. Heins, Joke C. Korevaar, Mieke Rijken, François G. Schellevis

To examine health care utilization of people with multiple chronic diseases in The Netherlands compared to people with a single chronic disease, and to identify subgroups of multimorbid patients... more

Oxygen therapy in COPD patients with isolated nocturnal hypoxemia; comparison of quality of life and sleep between bronchitis and emphysema phenotype: A prospective observational study

8 September 2016
Author(s): Maurizio Rizzi, Andrea Airoldi, Andrea Cristiano, Francesca Frassanito, Claudio Macaluso, Silvia Vanni, Delfino Legnani

COPD is a heterogeneous disease composed by two main phenotypes: bronchitis (COPDb) and emphysema (COPDe) with different clinical presentation, physiology, imaging, response to therapy and decline in... more

Clinical frailty adds to acute illness severity in predicting mortality in hospitalized older adults: An observational study

2 September 2016
Author(s): Roman Romero-Ortuno, Stephen Wallis, Richard Biram, Victoria Keevil

Frail individuals may be at higher risk of death from a given acute illness severity (AIS), but this relationship has not been studied in an English National Health Service (NHS) acute hospital... more

Association of glycated hemoglobin with hemoglobin levels in elderly nondiabetic subjects

1 September 2016
Author(s): Alon Grossman, Anat Gafter-Gvili, Hemda Schmilovitz-Weiss, Nira Koren-Morag, Yichayaou Beloosesky, Avraham Weiss

Glycated hemoglobin (HgbA1C) is being increasingly used for the diagnosis of diabetes mellitus due to its high availability and reproducibility. Several studies have shown that HgbA1C levels may be... more

Review Article

C-reactive protein (CRP) measurement in geriatric patients hospitalized for acute infection

1 September 2016
Author(s): Andrea Ticinesi, Fulvio Lauretani, Antonio Nouvenne, Emanuela Porro, Guido Fanelli, Marcello Maggio, Tiziana Meschi

The physiology of inflammatory response is modified by the aging process and is substantially affected by multimorbidity and disability. Infection is the most frequent cause of acute inflammation in... more


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