Proton-Pump Inhibitors (PPIs) are commonly prescribed medications indicated for the treatment of various acid-related disorders including duodenal/gastric ulcers, erosive oesophagitis and Helicobacter Pylori eradication1,2. PPIs are frequently used without appropriate indication in older adults and are associated with numerous adverse effects including bone loss, fractures, community acquired pneumonia and chronic kidney disease1,2. Strikingly, several studies have also reported a greater risk of dementia in those receiving a long-term PPI3,4.
