Whipple's disease (WD) is a chronic, systemic, relapsing infection theoretically capable of affecting any organ, but primarily affects the joints, the mucosa of the small intestine, and the central nervous system [1–4]. It is an exceedingly rare condition (prevalence of 1–3 per 1,000,000) predominantly affecting middle-aged Caucasian men [4–6]. Specifically, the mean age at diagnosis is 55 years, and 85 % of patients are male [5]. Although the majority of patients can be effectively treated with antibiotics, the prognosis may become poor in cases of relapse with serious involvement of the central nervous system or in the presence of immune reconstitution inflammatory syndrome (IRIS) [3,7].
