The prevalence of hypertensive disorders of pregnancy (HDP) steadily increased in past years partly because of advanced maternal age and partly because of ever-wider access to assisted reproduction techniques in women with pre-existing complex medical conditions [1]. Preeclampsia (PE), the most severe type of hypertensive disorder of pregnancy (HDP), is the leading cause of maternal and perinatal morbidity and mortality. PE is a pregnancy-associated syndrome involving multiple organs with long-term health implications for both mothers and their offspring [2].
