April 2020

9 Articles


Alcohol intake and atrial fibrillation: A new topic in gender medicine

20 April 2020
Author(s): Fabio Angeli, Roberto De Ponti, Paolo Verdecchia

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and a major risk factor for stroke, heart failure, hospitalization and mortality [1–3]. It affects... more

Prolyl-hydroxylase domain inhibitors in chronic kidney disease, a promising alternative for erythropoiesis-stimulating agent

20 April 2020
Author(s): A. Rubinsztajn, D. Fouque

Anemia is one of the most common complications during chronic kidney disease (CKD) and results from a progressive lack of erythropoietin (EPO). EPO plays a major role in erythropoiesis by inducing... more

Risk stratification vs routine intensive care stay in non ST segment elevation myocardial infarction (NSTEMI)

13 April 2020
Author(s): Stefano Savonitto, Nuccia Morici

Non-ST-segment-elevation acute coronary syndromes (NSTE ACS) encompass a wide spectrum of clinical conditions characterised by acute ischemic symptoms, electrocardiographic signs of myocardial... more

Letter to the Editor

SARS-CoV-2 detection in the pericardial fluid of a patient with cardiac tamponade

22 April 2020
Author(s): Andrea Farina, Giuseppe Uccello, Marta Spreafico, Giorgio Bassanelli, Stefano Savonitto

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus first identified in Wuhan, China, at the end of 2019. Since then it has caused more than 1,700,000 confirmed cases... more

Factors associated with mortality in patients with COVID-19. A quantitative evidence synthesis of clinical and laboratory data

22 April 2020
Author(s): Paulo Ricardo Martins-Filho, Carolina Santos Souza Tavares, Victor Santana Santos

The COVID-19 pandemic caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) has become a serious challenge for health systems worldwide. Despite the favorable clinical course for most... more

Is low sodium intake a risk factor for severe and fatal COVID-19 infection?

7 April 2020
Author(s): Adrian Post, Robin P.F. Dullaart, Stephan J.L. Bakker

As of March 16th, the number of deaths due to the coronavirus 2019 (COVID-19) outside China has surpassed those in China. Intriguingly, recent calculations that adjust for an incubation period of up... more

Review Article

Antisense lipoprotein[a] therapy: State-of-the-art and future perspectives

24 April 2020
Author(s): Giuseppe Lippi, Emmanuel J. Favaloro, Fabian Sanchis-Gomar

Lipoprotein[a] (Lp[a]) is an enigmatic low density lipoprotein (LDL)-like particle, in which apolipoprotein B100 (apoB100), the main protein moiety of LDL, is covalently linked through a single... more

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

20 April 2020
Author(s): Paolo Verdecchia, Claudio Cavallini, Antonio Spanevello, Fabio Angeli

Angiotensin converting enzyme-2 (ACE2) receptors mediate the entry into the cell of three strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are ubiquitous and widely expressed in... more

The challenge of implementing Less is More medicine: A European perspective

15 April 2020
Author(s): Omar Kherad, Nathan Peiffer-Smadja, Lina Karlafti, Margus Lember, Nathalie Van Aerde, Orvar Gunnarsson, Cristian Baicus, Miguel Bigotte Vieira, António Vaz-Carneiro, Antonio Brucato, Ivica Lazurova, Wiktoria Leśniak, Thomas Hanslik, Stephen Hewitt, Eleni Papanicolaou, Olga Boeva, Dror Dicker, Biljana Ivanovska, Pinar Yldiz, Patrick Lacor, Mark Cranston, Frauke Weidanz, Giorgio Costantino, Nicola Montano

Healthcare systems in developed countries are facing new challenges that include defining the values, objectives and tasks of sustainable medicine. Near universal access to quality health care is one... more


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