April 2023

29 Articles

No Section

Intravenous pulse methylprednisolone for the treatment of severe COVID-19

16 February 2023
Author(s): Dimitrios Patoulias, Athina Dimosiari

Corticosteroids still represent one of the cornerstone treatment options for subjects hospitalized with coronavirus disease 2019 (COVID-19), especially for those suffering from a severe form of the... more


Lung ultrasound must be the first-line image technique in COVID-19 patients

19 February 2023
Author(s): Juan Torres-Macho, Miguel Angel Casado-Suela, Mercedes Duffort-Falcó

Lung ultrasound (LUS) is a paradigm of Point of Care Ultrasound values. First, it has no “owner” because its use has been developed by different specialties such as Intensive Care Medicine, Emergency... more

De-escalation in intensity or duration of dual antiplatelet therapy in patients with coronary artery disease: More than alternative treatment options

19 February 2023
Author(s): Antonio Landi, Serena Caglioni, Marco Valgimigli

Antithrombotic therapy represents the mainstay of pharmacological treatments in patients with acute or chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI) [1]. Since... more

Endovascular therapy for basilar occlusion: Is there robust evidence?

6 February 2023
Author(s): Maurizio Paciaroni

The combined rate of mortality and severe disability for patients with acute basilar artery occlusion is as high as 90% [1,2]. Observational studies report that with revascularization therapies this... more

Internal Medicine Flashcard

Hepatobiliary diseases

10 January 2023
Author(s): Yuanhao Xia, Hao Guo, Heng Ma

A 60-year-old woman had been diagnosed with Gallstone five years previously. The patient's symptoms were relieved following anti-inflammatory therapy for one week. She was now admitted to... more

Zosteriform erythematous rash

28 December 2022
Author(s): Siddhartha Dash, Biswanath Behera, Vishal Thakur

A 70-years-old male presented with unilateral rash below the right axilla of one-month duration. The patient gave history of cough with shortness of breath for the last two years and pain in the... more

Letter to the Editor

Treatment of acute alcohol intoxication: The role of metadoxine

14 February 2023
Author(s): Antonio Mirijello, Giovanni Addolorato

Dear Editor,

Evolution of the SARS-CoV-2 epidemic: From genomic surveillance to new health needs

10 February 2023
Author(s): Andrea Giacomelli, Anna Lisa Ridolfo, Letizia Oreni, Giuliano Rizzardini, Spinello Antinori

Dear editor

Lower risks of incident colorectal cancer in SGLT2i users compared to DPP4i users: A propensity score-matched study with competing risk analysis

31 January 2023
Author(s): Raymond Ngai Chiu Chan, Robert Ngai Fung Chan, Oscar Hou In Chou, Gary Tse, Sharen Lee

Dear Editor,

Long-term prognostic capacity of multi-comorbid indices in chronic obstructive pulmonary disease

26 December 2022
Author(s): Rocio Reinoso-Arija, Laura Carrasco-Hernandez, Candelaria Caballero Eraso, Esther Quintana-Gallego, Jose Luis López-Campos

Dear Editor,

Risk of obstructive sleep apnea in idiopathic pulmonary fibrosis

22 December 2022
Author(s): Tang-Chuan Wang, Te-Chun Shen, Cheng-Li Lin, Chung Y. Hsu

To the editor,

Timeline analysis of clinical severity of COVID-19 in the general population

16 December 2022
Author(s): Camilla Mattiuzzi, Giuseppe Lippi

We read with interest the recent article of Giacomelli et al. [1], who showed that the main characteristics of patients hospitalised with coronavirus disease 2019 (COVID-19) have substantially... more

Lack of efficacy of Interferon β-1a in COVID-19 patients with mild to moderate pneumonia

1 December 2022
Author(s): Carlo Bosi, Roberto Ferrarese, Rebecca De Lorenzo, Nicasio Mancini, Emanuele Bosi, INTERCOP study group

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2), poses an unprecedented threat for global health. Even in the context of intensified vaccine... more

Hypersensitivity reactions associated with iron isomaltoside and ferric carboxymaltose

30 November 2022
Author(s): Carmelo Aguirre, Itziar Palacios-Zabalza, Igor Ceruelo, Ainhoa Txintxurreta-Albizua, Montserrat García

Dear editor,

Hip involvement in familial Mediterranean fever

24 November 2022
Author(s): François Rodrigues, Jérémie Sellam, Pierre Quartier, Stéphanie Ducharme-Bénard, Sophie Georgin-Lavialle

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder that is linked to homozygous mutations of the MEFV gene [1]. The field of FMF is expanding as many patients with FMF... more

Aspirin and P2Y12 inhibitors in treating COVID-19

22 November 2022
Author(s): Amirmohammad Khalaji, Amir Hossein Behnoush, Soheil Peiman

Dear Editor,

Endovascular Thrombectomy in Basilar-Artery Occlusion Stroke

21 November 2022
Author(s): Rahul Gupta, Amir Hossein Behnoush, Amirmohammad Khalaji, Aaqib H Malik, Bryan Kluck, Cardiovascular Research Study Group

Dear Editor;

Original Article

Prevalence of non-alcoholic fatty liver disease in a multicentre cohort of people living with HIV in Spain.

8 February 2023
Author(s): Jordi Navarro, Adrian Curran, Berta Raventós, Jorge García, Paula Suanzes, Vicente Descalzo, Patricia Álvarez, Nuria Espinosa, Marisa Luisa Montes, Inés Suárez-García, Concha Amador, Roberto Muga, Vicenç Falcó, Joaquín Burgos, Spanish HIV Research Network (CoRIS)

Since the beginning of the history of HIV infection, liver disease has been one of the major causes of morbidity and mortality in people living with HIV (PLWH) [1]. Even though the emergence of the... more

Functional outcome after cardiac rehabilitation and its association with survival in heart failure across the spectrum of ejection fraction

7 February 2023
Author(s): Domenico Scrutinio, Pietro Guida, Maria Teresa La Rovere, Maurizio Bussotti, Ugo Corrà, Giovanni Forni, Rosa Raimondo, Simonetta Scalvini, Andrea Passantino

Heart failure (HF) is an increasingly prevalent clinical syndrome and a major cause of cardiovascular mortality and morbidity [1,2]. Functional disability and loss of independence are hallmark... more

Trends in prevalence and all-cause mortality of metabolic dysfunction-associated fatty liver disease among adults in the past three decades: Results from the NHANES study

6 February 2023
Author(s): Zhi-Qin Xie, Hong-Xia Li, Bing-Kun Wang, Zhao-Ming Yang, Zi-Yu Zhang, Wen-Liang Tan, Wen-Xin Li, Qing-Bin Wang, Lei Yang, Hong-Kai Zhuang, Chen-Wei Tang, Chang-Zhen Shang, Ya-Jin Chen

Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease, with an overall prevalence of 25%–32.4% worldwide, imposing a considerable health and economic burden [1,2]. Given... more

Circulating GDF-15 in relation to the progression and prognosis of chronic kidney disease: A systematic review and dose-response meta-analysis

3 February 2023
Author(s): Zhongwei Zhou, Hongli Liu, Huixiang Ju, Hongmei Chen, Hao Jin, Mingzhong Sun

Chronic kidney disease (CKD) has been a health problem worldwide that is characterized by the high incidence, poor prognosis, and large healthcare cost [1]. Since CKD has insidious onset and atypical... more

Higher diagnostic yield of 18F-FDG PET in inflammation of unknown origin compared to fever of unknown origin

2 February 2023
Author(s): Albrecht Betrains, Lennert Boeckxstaens, Lien Moreel, William F. Wright, Daniel Blockmans, Koen Van Laere, Steven Vanderschueren

18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging often plays an important role in the workup of fever of unknown origin (FUO) and inflammation of unknown origin (IUO),... more

The efficacy and safety of tacrolimus in patients with dermatomyositis/polymyositis: A meta-analysis and systematic review

30 January 2023
Author(s): Jiafen Liao, Xiaofei Peng, Jiayi Liu, Xi Xie, Jia Wang

Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune inflammatory muscle disorders characterized by muscle weakness and multisystem involvement, especially in skin and lungs.... more

Comparison of missed adenomas in deep-sedated and unsedated colonoscopy: A multicenter retrospective study

27 January 2023
Author(s): Yue Sui, Yanhua Zheng, Qing Wang, Jieping Lv, Hongjin Wang, Qing Wen, Zhenzhen Wang, Guanfeng Wang, Hui Jia, Fengzhen Cao, Naping Wang, Junlian Hao, Yiping Zhang, Xiaopeng Wu, Haihua Chen, Junhui Lu, Xing Chen

According to the Global Cancer Report 2020, colorectal cancer ranks third in incidence and second in mortality of cancer-related diseases worldwide [1]. Colonoscopy is currently considered the gold... more

The clinical presentation of syncope influences the head-up tilt test responses

11 January 2023
Author(s): Vincenzo Russo, Erika Parente, Angelo Comune, Nunzia Laezza, Anna Rago, Paolo Golino, Gerardo Nigro, Michele Brignole

The nitroglycerin (NTG) potentiated head-up tilt test (HUTT) positivity rate was about 1.5 times higher in patients with classical vasovagal (VVS) compared to those with non-classical VVS. The higher... more

Efficacy of endovascular therapy for basilar and vertebral artery occlusion: A systematic review and meta-analysis of randomized controlled trials

24 December 2022
Author(s): Chun-Hsien Lin, David S Liebeskind, Bruce Ovbiagele, Meng Lee, Jeffrey L Saver

The best management for acute basilar artery occlusion (BAO) has increasingly been clarified by recent randomized controlled trials (RCTs). We conducted a systematic review and meta-analysis of RCTs... more

Long-term lung ultrasound follow-up in patients after COVID-19 pneumonia hospitalization: A prospective comparative study with chest computed tomography

7 December 2022
Author(s): Greta Barbieri, Luna Gargani, Vittoria Lepri, Stefano Spinelli, Chiara Romei, Annalisa De Liperi, Davide Chimera, Francesco Pistelli, Laura Carrozzi, Francesco Corradi, Lorenzo Ghiadoni, Pisa COVID-19 Study Group

From December 2019, the medical scenario has been characterized by the SARS-CoV-2 pandemic that put a strain on the healthcare systems all around the world. Human-to-human aerosol transmission as... more

Review Article

Pathophysiology of cough with angiotensin-converting enzyme inhibitors: How to explain within-class differences?

9 January 2023
Author(s): Claudio Borghi, Arrigo FG Cicero, Davide Agnoletti, Giulia Fiorini

Angiotensin-converting enzyme inhibitors (ACEi) are largely used for the prevention and treatment of cardiovascular and renal diseases [1]. The rationale supporting the use of ACEi is based on... more

De-escalation of antiplatelet therapy in patients with coronary artery disease: Time to change our strategy?

25 December 2022
Author(s): Pierre Sabouret, Luigi Spadafora, David Fischman, Waqas Ullah, Michel Zeitouni, Martha Gulati, Salvatore De Rosa, Michael P. Savage, Juan Pablo Costabel, Maciej Banach, Giuseppe Biondi-Zoccai, Mattia Galli

Since more than two decades, dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is considered the gold standard for patients with acute coronary syndrome (ACS) as well as... more


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