Published: 11 May 2020
Author(s): Federico Carbone, Aldo Bonaventura, Alessandra Vecchiè, Jennifer Meessen, Silvia Minetti, Edoardo Elia, Daniele Ferrara, Anna Maria Ansaldo, Giorgio Tulli, Diletta Guarducci, Nicola Rossi, Francesco Bona, Marta Ferrari, Pietro Caironi, Roberto Latini, Fabrizio Montecucco
Issue: August 2020
Section: Original article

Despite substantial advances in clinical understanding and disease definition, sepsis remains the leading cause of death in intensive care units (ICUs) [1]. Furthermore, progress in medical care have not only determined an escalation of sepsis-associated costs, but also a rise in long-term mortality [2]. Considering this epidemiological trend, a “trimodal” pattern has been suggested as the current paradigm of sepsis-related mortality. Whereas the two early peaks (within first weeks) are well-known, a third spike on long-term mortality (from 2-3 month up to 3 years after sepsis) is emerging [3].


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