We would like to thank Dr. Davide Giuseppe Ribaldone and colleagues for their interest in our article “The contribution of clinical and pathological predisposing factors to severe gastro-duodenal lesions in patients with long-term low-dose aspirin and proton pump inhibitor therapy” [1].They raised the problem of possible false negative diagnosis of Helicobacter pylori (H. pylori) infection using biopsy in patients with ongoing treatment with proton pump inhibitors (PPI) and offer us the opportunity to clarify some methodological aspects.
