December 2020

27 Articles

No Section

Erectile dysfunction and adherence to antihypertensive therapy: Focus on β-blockers

18 July 2020
Author(s): Athanasios Manolis, Michael Doumas, Claudio Ferri, Giuseppe Mancia

Arterial hypertension is a major public health issue because it affects more than 1.1 billion patients worldwide [1], and represents a very important risk factor for the development of cardiac,... more


Erectile dysfunction and arterial hypertension: Still looking for a scapegoat

16 September 2020
Author(s): Giovanni de Simone, Costantino Mancusi

Hypertension awareness, treatment and control have improved substantially in the past 40 years. However, control rates have plateaued in the past decade in many countries, and a substantial... more

Gender differences in long-term prognosis after NSTEACS: Now you see me, now you don't!

1 September 2020
Author(s): Gaia Cattadori, Isabella Tritto, Giuseppe Ambrosio

It is known that women are often underrepresented, or even excluded, in randomized clinical trials, the results of which consequently may not be entirely reproduced in the general population. At the... more

Internal Medicine Flashcard

What ‘s the link between otological signs and oral contraception?

25 September 2020
Author(s): Laurence Salle, Henri Salle

A 48-year-old woman presented chronic headache and serous otitis with feeling of fullness of the right ear. She had no medical or surgery history. ENT and clinical neurological examination revealed... more

Paroxysmal Atrial Fibrillation on Flecainide Therapy

24 September 2020
Author(s): Jordan L Gavin, Graham S Peigh, Susan S Kim

Flecainide pill-in-the-pocket therapy is a pharmacologic treatment option for patients with infrequent episodes of symptomatic atrial fibrillation. We report a case of wide complex tachycardia due to... more

Chest pain in a middle-aged smoker with heart failure and missing lung

23 September 2020
Author(s): Sarah Hossain, Afif Hossain, Aldo Barajas-Ochoa

A 45-year-old man presented with sharp, left-sided chest pain of one-hour duration that radiated to the right chest and back, and started two hours after snorting cocaine. He was an active smoker and... more

Bilateral hilar opacities

23 September 2020
Author(s): João A. Cunha Neves, Maria Margarida Rosado, Marcelo Gordinho

A 20-year-old male was admitted to the emergency department with a 1-week history of fever, right pleuritic chest pain and aggravating sporadic hemoptoic cough.

Letter to the Editor

Change over time of COVID-19 hospital presentation in Northern Italy

25 September 2020
Author(s): Giuseppe Patti, Marco Mennuni, Francesco Della Corte, Enrico Spinoni, Pier Paolo Sainaghi, for the COVID-UPO Clinical Team

After the first autochthonous case described on February 19, also in Italy the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection rapidly circulated, mainly in the Northern... more

COVID-19 randomized controlled trials in medRxiv and PubMed

22 September 2020
Author(s): Yuki Kataoka, Shiho Oide, Takashi Ariie, Yasushi Tsujimoto, Toshi A. Furukawa

Fast-track preprints have garnered increased attention since the COVID-19 pandemic. However, little is known about the quality of clinical research published as preprints. The objective of this study... more

Do biomarkers add anything to clinical prediction of mortality in older medical emergency department patients?

25 July 2020
Author(s): Noortje Zelis, Jacqueline Buijs, Peter W. de Leeuw, Patricia M. Stassen, RISE UP investigator group

Recently, we described in this Journal a simplified, yet accurate clinical decision model (the RISE UP score) to predict 30-day mortality in older patients who visit an emergency department [1].... more

Italian Vò municipality cohort and COVID-19 epidemiology: The “Framingham” study of the 21st century

21 July 2020
Author(s): Marco Zuin, Claudio Bilato, Giovanni Zuliani, Loris Roncon

The small Italian municipality of Vò, located in the Veneto region, northeast of Italy, with a population of nearly 3200 inhabitants, suffered the first COVID-19-related death of the country on... more

Waste in COVID-19 clinical trials conducted in western Europe

9 July 2020
Author(s): Rafael Dal-Ré, Ignacio Mahillo-Fernández

Amid huge efforts to address the therapeutic uncertainties clinicians are facing with COVID-19 patients’ management, many clinical trials are badly designed [1]. Trials with no control group and with... more

Romeo and Juliet: Revisited (at the time of COVID-19)

8 July 2020
Author(s): Giorgio Costantino, Flora Peyvandi, Nicola Montano, Carlo Agostoni

Once upon a time, EM, a 27-years old female resident in Internal Medicine, fell in love with JP, a 27-yrs male, a resident as well. It happens, in the pre-COVID-19 Milan, Lombardy, Italy.

The additive diagnostic value of heart-type fatty acid binding protein in patients presenting early with chest pain

6 July 2020
Author(s): Gassan Moady, Daisy Shtern, Shaul Atar

Acute myocardial infarction (AMI) is one of the most serious conditions encountered in the emergency room (ER), with outcomes that are highly affected by the time elapsed since symptoms onset. The... more

Original Article

Limited prognostic accuracy of the CRB-65 and qSOFA in patients presenting with pneumonia and immunosuppression

7 August 2020
Author(s): Sophie Frantz, Bernhard Schulte-Hubbert, Michael Halank, Dirk Koschel, Martin Kolditz

Pneumonia remains an important health concern in the western world, with highly variable mortality rates [1]. Initial risk stratification to objectify prognosis is the first step in managing patients... more

Interdependence of VA-ECMO output, pulmonary congestion and outcome after cardiac surgery

28 July 2020
Author(s): Klaus Distelmaier, Dominik Wiedemann, Katharina Lampichler, Daniel Toth, Lukas Galli, Thomas Haberl, Barbara Steinlechner, Gottfried Heinz, Günther Laufer, Irene M. Lang, Georg Goliasch, Walter S. Speidl

Venoarterial-extracorporeal membrane oxygenation (VA-ECMO) is a life-saving method for patients with low-output failure after cardiac surgery. Although the use of VA-ECMO after cardiac surgery is... more

Sympathetic activation and outcomes in chronic heart failure: Does the neurohormonal hypothesis apply to mid-range and preserved ejection fraction patients?

25 July 2020
Author(s): Santiago Jimenez-Marrero, Pedro Moliner, Iris Rodríguez-Costoya, Cristina Enjuanes, Lidia Alcoberro, Sergi Yun, Jose Gonzalez-Costello, Alberto Garay, Marta Tajes, Esther Calero, Encarnación Hidalgo, Carmen Guerrero, Elena García-Romero, Carles Díez-López, Miguel Cainzos-Achirica, Josep Comin-Colet

body mass index

Safety and efficacy of anticoagulant monotherapy in atrial fibrillation and stable coronary artery disease: A systematic review and meta-analysis

22 July 2020
Author(s): Waqas Ullah, Yasar Sattar, Mishal Shaukat, David L. Fischman

Coronary artery disease (CAD) and atrial fibrillation (AF) have emerged as new cardiovascular epidemics in the modern era posing a high risk for acute coronary and cerebrovascular events,... more

Rifabutin-Based Triple Therapy Or Bismuth-Based Quadruple Regimen As Rescue Therapies For Helicobacter pylori Infection

6 July 2020
Author(s): Ilaria M. Saracino, Matteo Pavoni, Angelo Zullo, Giulia Fiorini, Laura Saccomanno, Tiziana Lazzarotto, Guido Antonelli, Rossana Cavallo, Claudio Borghi, Dino Vaira

H. pylori causes chronic gastritis and peptic ulceration, and concurs to gastric MALT lymphoma and carcinoma development [1]. Treatment of the infection remains a challenge for clinicians, as no... more

Systemic sclerosis is an independent risk factor for ischemic heart disease, especially in patients carrying certain antiphospholipid antibodies: A large cross-sectional study

30 June 2020
Author(s): Abdulla Watad, Dennis McGonagle, Nicola L. Bragazzi, Giovanni Damiani, Doron Comaneshter, Merav Lidar, Arnon D. Cohen, Howard Amital

Rheumatic diseases are characterized by chronic inflammation that affects the joints but also internal organs such as lungs, heart and other organs [1,2]. These disorders, if untreated, may lead to... more

Malignancy in patients with myocardial infarction and non-obstructive coronary arteries: A systematic review and meta-regression

24 June 2020
Author(s): Francesco Pelliccia, Vincenzo Pasceri, Gaetano Tanzilli, Giulio Speciale, Paolo G Camici, Carlo Gaudio

A growing number of investigations has recently called attention to patients with myocardial infarction (MI) and non-obstructive coronary arteries (MINOCA) [1], who constitute an intriguing subgroup... more

Sex-related differences in long-term mortality and heart failure in a contemporary cohort of patients with NSTEACS. The cardiochus-HSUJ registry

18 June 2020
Author(s): Belén Álvarez Álvarez, Charigan Abou Jokh Casas, Rosa Agra Bermejo, Alberto Cordero, Ana Belén Cid Álvarez, Moisés Rodriguez Mañero, Noelia Bouzas Cruz, José María García Acuña, Angel Salgado Barreiro, José R. González-Juanatey

Non-ST segment elevation acute coronary syndrome (NSTEACS) is the most frequent manifestation of acute coronary syndromes (ACS) [1, 2]. Acute heart failure (HF) remains a common complication of ACS,... more

Clinical profile and 1-year clinical outcomes of super elderly patients admitted with acute heart failure

15 June 2020
Author(s): Miguel Lorenzo, Rafael de la Espriella, Gema Miñana, Gonzalo Núñez, Enrique Santas, Eduardo Núñez, Raquel Heredia, Anna Mollar, Jose Civera, Amparo Villaescusa, Clara Sastre, Adriana Conesa, Clara Bonanad, Antoni Bayés-Genís, Julio Núñez

HFpEF, heart failure with preserved ejection fraction.

Kidney dysfunction and short term all-cause mortality after transcatheter aortic valve implantation

30 May 2020
Author(s): Fabio Alfredo Sgura, Salvatore Arrotti, Paolo Magnavacchi, Daniel Monopoli, Davide Gabbieri, Federico Banchelli, Stefano Tondi, Andrea Denegri, Roberto D'Amico, Vincenzo Guiducci, Luigi Vignali, Giuseppe Boriani

Transcatheter aortic valve implantation (TAVI) has been proven to be the preferred procedure for patients with symptomatic aortic stenosis (AS) who do not qualify for surgery [1-2]. TAVI has been... more

Review Article

Management of chronic refractory cough in adults

19 September 2020
Author(s): Dina Visca, Bianca Beghè, Leonardo Michele Fabbri, Alberto Papi, Antonio Spanevello

Cough is a physiological response to mechanical and chemical stimuli due to irritation of cough receptors located mainly in the epithelium of the upper and lower respiratory tracts, pericardium,... more

Point of care ultrasound for rapid assessment and treatment of palliative care patients in acute medical settings

14 August 2020
Author(s): Neal Breakey, Joseph Osterwalder, Gebhard Mathis, Beat Lehmann, Thomas C Sauter

The combination of an ageing population with improving survival in malignant and non-malignant disease processes results in a growing cohort of the population who live with advanced or end-stage... more


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