December 2022

29 Articles


Moving forward with point-of-care ultrasound: An (early) educational effort can (also) strengthen research

10 October 2022
Author(s): R. Schiavon, F. Casella, C. Cogliati

The growing availability of portable ultrasound equipment, associated with the rapidity of execution and the perceived benefit on diagnostic accuracy and time-to-diagnosis, has led to an exponential... more


Corrigendum to ‘External validation of risk scores to predict in-hospital mortality in patients hospitalized due to coronavirus disease 2019’

21 September 2022
Author(s): Shermarke Hassan, Chava L. Ramspek, Barbara Ferrari, Merel van Diepen, Raffaella Rossio, Rachel Knevel, Vincenzo la Mura, Andrea Artoni, Ida Martinelli, Alessandra Bandera, Alessandro Nobili, Andrea Gori, Francesco Blasi, Ciro Canetta, Nicola Montano, Frits R. Rosendaal, Flora Peyvandi, LUMC-COVID-19 Research Group, COVID-19 Network working group

The authors regret that the Appendix was missing as supplementary material with the above publication. The Appendix is now published online with this corrigendum.


Community-acquired pneumonia – An EFIM guideline critical appraisal adaptation for internists

19 October 2022
Author(s): Ahmet Gorkem Er, Alberto Antonio Romero Alonso, Ignacio Marin-Leon, Abdullah Sayiner, Stefano Bassetti, Kutay Demirkan, Patrick Lacor, Hartmut Lode, Wiktoria Lesniak, Mine Durusu Tanriover, Ali Fuat Kalyoncu, Nicolás Merchante, Serhat Unal

Community-acquired pneumonia (CAP) is defined as an acute infection of the pulmonary parenchyma acquired outside the hospital and, is one of the most important causes of morbidity and mortality... more

Internal Medicine Flashcard

A woman with purple-brown skin lesions after immunosuppressive therapy

11 October 2022
Author(s): Konstantinos Liapis, Zoe Bezirgiannidou, Ioannis Kotsianidis

An 80-year-old Greek woman presented to our clinic with fatigue and new-onset skin lesions around her neck, enlarging and multiplying over the previous 6 weeks. The lesions were asymptomatic but had... more

A « tipical » but rare cause of neck pain

16 August 2022
Author(s): Quentin Richier, Jean-Yves Travers, Loïc Raffray

A 34-year-old man with medical history of familial deafness presented to the emergency department for an acute left cervicalgia and painful jaw for one week. He reported a context of recent physical... more

Not always “straight ahead” – A surprising cause of acute kidney injury

16 August 2022
Author(s): Meidad Greenberg, Alon Bnaya, Keren Cohen-Hagai

A 16-year-old girl presented with a complaint of vomiting and abdominal pain, which appreared immediately following hair straightening treatment. Her medical history was remarkable for untreated... more

Letter to the Editor

Persistent FDG uptake in large vessels and risk of relapse in giant cell arteritis

9 September 2022
Author(s): Deborah Eshagh, Arthur Mageau, Thomas Papo, Khadija Benali, Karim Sacre

Giant cell arteritis (GCA) is a large vessel vasculitis that typically involves the extracranial branches of the aorta [1]. Steroids and anti-IL6 are highly effective in obtaining remission but the... more

Chronological aspects of atrial fibrillation after myocardial infarction

2 September 2022
Author(s): Tomonari Shimoda, Noriaki Kou, Yui Okamura, Ryusuke Imanishi, Hiroshi Ito

Dear editor,

Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension incidence in Latvia in 2021 according to the new definition

29 August 2022
Author(s): Dana Kigitovica, Elina Rusa, Ainars Rudzitis, Andris Skride

Pulmonary hypertension is a progressive disease that is classified into 5 clinical subgroups, leading to the right ventricular failure and high mortality. The 6th World Symposium on Pulmonary... more

Efficacy and safety of Mavacamten: A new era in the treatment of hypertrophic cardiomyopathy

29 August 2022
Author(s): Mahnoor Sukaina, Marium Waheed, Naba Ali, Raffat Rasool

Hypertrophic cardiomyopathy (HCM) is a condition in which the myocardium is hypertrophied. HCM is the most common genetic cardiovascular disease and the most common cause of death in young adults [1... more

Atrial remodeling predicts the first cardiovascular diseases hospitalization in patients with type II diabetes mellitus

29 August 2022
Author(s): Chenglin Li, Fei Liu, Yunlong Xia, Lei Zhong, Xiaolei Yang

Atrial cardiomyopathy (ACM) is a dynamic process, characterized by progressive structural, architectural, contractile, and/or electrophysiological remodeling that affects the atria [1]. ACM is... more

The positive impact of coronary computed tomography angiography-based strategies on the clinical outcomes of patients with diabetes mellitus

27 August 2022
Author(s): Shingo Kato, Nobuyuki Horita, Daisuke Utsunomiya

Coronary computed tomography angiography (CTA) screening for coronary artery disease (CAD) is an indispensable diagnostic tool in clinical practice because of its excellent negative predictive value... more

In COVID-19 patients with mild or moderate respiratory failure, duration and type of symptoms influence the diagnostic accuracy of lung ultrasound

23 August 2022
Author(s): Pawlowska Victoria, Coucke Christophe, Noirez Leslie, Papadimitriou-Olivgeris Matthaios, Monti Matteo

The SARS-CoV-2 pandemic has placed considerable pressure on healthcare systems worldwide, forcing hospitals to implement strict infection control measures aimed at isolating all suspected cases. To... more

Publication and citation inequalities faced by African researchers

17 August 2022
Author(s): Paul Sebo

The study of discrimination in research focused primarily on gender inequalities [1,2], and programs were launched in many countries to increase representation of women in key-positions and improve... more

Is the benefit of sodium-glucose cotransporter inhibitors over heart failure progression on the kidney side?

16 August 2022
Author(s): Edoardo Gronda, Massimo Iacoviello, Domenico Gabrielli, Pasquale Caldarola, Luigi Tavazzi, CArdiac REnal MEtabolic (CARE ME) Scientific Area, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO)

Dear Editor,

Gastrointestinal adverse events of semaglutide in patients with overweight or obesity

16 August 2022
Author(s): Muhammad Ali Tariq, Hamza Amin, Qazi Shurjeel, Ahmed Gang, Ashar Mohiuddin

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) and is a well-established, safe, and effective treatment for type 2 diabetes mellitus (T2DM) with favorable effects on glycemic... more

A reappraisal of corticosteroids use for COVID-19

15 August 2022
Author(s): Ilaria Pati, Francesca Masiello, Simonetta Pupella, Mario Cruciani, Vincenzo De Angelis

The current evidence suggests that the rapid clinical progression of the Coronavirus Disease 2019 (COVID-19) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is... more

Original Article

Angiopoietins, vascular endothelial growth factors and secretory phospholipase A2 in heart failure patients with preserved ejection fraction

22 October 2022
Author(s): Gilda Varricchi, Remo Poto, Anne Lise Ferrara, Giuseppina Gambino, Gianni Marone, Giuseppe Rengo, Stefania Loffredo, Leonardo Bencivenga

Heart failure (HF) represents a growing public health burden with an estimated prevalence in Europe and United States ranging from 0.4% to 2% [1]. According to the 2021 European Society of Cardiology... more

Short versus long course therapy in the treatment of febrile urinary tract infections in men based on serum PSA values

21 October 2022
Author(s): Helena Monzón, Laura Gisbert, Meritxell Salvadó, Miquel Puyol, Mariona Xercavins, Asunción Gasós, Maria Sanjaume, Beatriz Dietl, Josep Maria Caballero, Patricia Sigüenza, Ángeles Jaen, Javier Garau, Esther Calbo

The incidence of urinary tract infections (UTIs) varies with sex, age and predisposing conditions. UTI more frequently afflicts women than men at all ages, except in the first year of life [1].

Etiological spectrum and outcome of fever and inflammation of unknown origin. Does symptom duration matter?

16 October 2022
Author(s): A. Betrains, W.F. Wright, L. Moreel, F. Staels, D. Blockmans, S. Vanderschueren

Evidence suggests that the symptom duration may affect the occurrence of certain fever (FUO) and inflammation (IUO) of unknown origin associated conditions. It is unclear if this could potentially... more

Functional and metabolic frailty predicts mortality in patients undergoing TAVI: Insights from the OBSERVANT II study

3 October 2022
Author(s): Mauro Massussi, Marianna Adamo, Stefano Rosato, Fulvia Seccareccia, Marco Barbanti, Fausto Biancari, Giuseppe Tarantini, Sebastiano Immè, Luigi Vignali, Gabriella Badoni, Gian Paolo Ussia, Giuliano Costa, Massimo Baiocchi, Marco Metra, Giovanni Baglio, Paola D'Errigo, The OBSERVANT II Research Group

Frailty is defined as a decrease of physiologic reserve and ability to maintain homeostasis leading to an increased vulnerability to adverse events [1]. Frailty is prevalent among elderly subjects... more

Proton pump inhibitors and the risk of cardiovascular events and cardiovascular mortality: A systematic review and meta-analysis of observational studies

1 October 2022
Author(s): Michael Nolde, Nayeon Ahn, Tobias Dreischulte, Evamaria Krause, Florian Güntner, Alexander Günter, Roman Gerlach, Martin Tauscher, Ute Amann, Jakob Linseisen, Christa Meisinger, Sebastian-Edgar Baumeister, Ina-Maria Rückert-Eheberg

Proton pump inhibitors (PPIs) are widely used to treat disorders characterized by excessive gastric acid production [1] and have been sold over-the-counter for more than one decade. Alongside, PPIs... more

High cardiovascular disease risk-associated with the incidence of Type 2 diabetes among prediabetics

22 September 2022
Author(s): Azam Dekamin, M.I.M. Wahab, Karim Keshavjee, Aziz Guergachi

Prediabetes, a state with a higher chance of developing diabetes, is a condition characterized by elevated blood glucose levels above the normal range but below the diabetes threshold. As a result,... more

Genetic testing in autoinflammatory diseases – past, current and future perspectives

21 September 2022
Author(s): Anouk Le Goueff, Guillaume Smits, Mélanie Delaunoy, Isabelle Vandernoot, Frédéric Vandergheynst

Autoinflammatory diseases (AIDs) or hereditary recurrent fevers (HRFs) are a group of rare and mostly monogenic illnesses with mendelian heredity. They are caused by a class IV or class V gene... more

Association of lipoprotein(a) with all-cause and cause-specific mortality: A prospective cohort study

18 September 2022
Author(s): Zhen-Wei Wang, Min Li, Jing-Jie Li, Nai-Feng Liu

Lipoprotein(a) [Lp(a)] was first discovered by Norwegian geneticist Berg in 1963 in the Nordic population [1]. Subsequently, it was proved to be a plasma lipoprotein determined by genes, consisting... more

Review Article

Acute aortic syndromes: An internist's guide to the galaxy

11 October 2022
Author(s): Fulvio Morello, Paolo Bima, Matteo Castelli, Peiman Nazerian

Acute aortic syndromes (AASs) are diseases involving the thoracic aorta, with variable involvement of the abdominal aorta and the main aortic branches, sharing common etiological, pathophysiological... more

Optimization of antimicrobial prescription in the hospital

11 September 2022
Author(s): T. Vieceli, J. Rello

Many obstacles in antimicrobial stewardship (AMS) are shared across high-income countries (HICs) and low and middle-income countries (LMICs). Some of the issues raised in a workshop by the American... more

POCUS in dyspnea, nontraumatic hypotension, and shock; a systematic review of existing evidence

1 August 2022
Author(s): Bram Kok, David Wolthuis, Frank Bosch, Hans van der Hoeven, Michiel Blans

Point-of-care ultrasound (POCUS) is defined as the integration of ultrasound imaging into the physical examination by the treating physician. It has shown to speed up the diagnostic process, and to... more


Stay informed on our latest news!


This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.