December 2023

30 Articles

Clinical Insights

Newer COVID-19 vaccines: Still lights and shadows?

25 October 2023
Author(s): Fabio Angeli, Martina Zappa, Paolo Verdecchia

Coronavirus Disease 2019 (COVID-19) vaccines are continuing to protect people from death, hospitalization, and severe clinical manifestations caused by severe acute respiratory syndrome coronavirus 2... more


Geographical and ethnoracial differences in venous thromboembolism and anticoagulation: An expanding horizon

31 October 2023
Author(s): Nicola Potere, Marco Paolo Donadini, Walter Ageno

Venous thromboembolism (VTE) carries a long-term risk of recurrence. Anticoagulation is administered with the aim of both treating the index VTE (initial management [first 5-21 days of diagnosis] and... more

What changed after the 2022 guidelines for pulmonary hypertension?

31 October 2023
Author(s): Daniele Guarino, Alberto Ballerini, Alessandra Manes

The 2022 European Society of Cardiology (ESC)/European Respiratory Society (ERS) Pulmonary Hypertension (PH) Guidelines have been reviewed by Mona Lichtblau et al., and the most important changes... more

Why the grass isn't always greener on the machine learning side

23 October 2023
Author(s): Anne de Hond, Menno Huisman, Maarten Van Smeden

In their article on predicting mortality in pulmonary embolism (PE) patients, El-Bouri and colleagues developed a prediction model to improve upon two existing pulmonary embolism scores, sPESI and... more

The fatty liver as testimonial of systemic diseases. Further evidence from rheumatoid arthritis and confirmation for a leading role of internal medicine

21 October 2023
Author(s): Agostino Di Ciaula, Leonilde Bonfrate, Piero Portincasa

Fat over-storage in the liver, in particular non-alcoholic fatty liver disease (NAFLD), has become the most frequent chronic liver disease worldwide [1]. At a global level, steatotic liver disease... more

Internal Medicine Flashcard

Sudden onset of left hemiplegia

2 September 2023
Author(s): Zhiwei Zhou, Tijiang Zhang, Ping Xu

A 65-year-old male presented with sudden onset of left hemiplegia for four hours, he was confused, blood pressure 158/109 mmHg, slightly delayed response, dysarthria, the muscle strength was 4/5 in... more

Respiratory failure following upper gastrointestinal endoscopy: A rare and unanticipated outcome to look out for

1 September 2023
Author(s): Ana Carolina Monteiro, Tomás França de Santana, Martim Trovão Bastos

A 67-year-old male patient was admitted to the Emergency Department with a one-week history of hematemesis and melaena. He was known to have liver cirrhosis secondary to alcoholic liver disease. Upon... more

Letter to the Editor

Cost-effectiveness analysis of ritonavir boosted nirmatrelvir for adult outpatients with mild to moderate COVID-19 in a European health system

7 October 2023
Author(s): Philip Wikman-Jorgensen, José María Ibarra, Carlos Devesa, Jorge Peris, Jara Llenas-García

After the coronavirus disease 2019 (COVID-19) emergency, there has been a search for antiviral drugs able to cure or ameliorate COVID-19 symptoms. In hospitalized patients requiring respiratory... more

Causes of death in nursing home residents during the pandemic

5 October 2023
Author(s): Ugo Fedeli, Marco Braggion, Silvia Pierobon, Claudio Barbiellini Amidei, Manuel Zorzi

Worldwide there are no official statistics on mortality in nursing homes (NH) during the pandemic. In 2020, deaths among NH residents in Europe accounted for 37–66 % of all COVID-19-related deaths [1... more

Chronic liver disease-related mortality during the COVID-19 pandemic

28 September 2023
Author(s): Donghee Kim, Richie Manikat, Karn Wijarnpreecha, George Cholankeril, Aijaz Ahmed

Chronic liver disease (CLD) is a major global health concern, accounting for approximately 2 million deaths annually worldwide [1]. Despite the advances in managing CLD over the past decade, CLD-... more

Interleukin-6 inhibition for the treatment of IgG4 related vasculitis

16 September 2023
Author(s): Veronica Batani, Claudia Minici, Francesca Sanvito, Elena Venturini, Emanuel Della-Torre, IgG4-RD OSR Clinic

Dear Editor

Performance of multi-biomarker panels based on urinary N-terminal osteopontin for prediction of diabetic kidney disease in patients with diabetes mellitus

13 September 2023
Author(s): Ling Sun, Yu Wu, Satyesh K. Sinha, Susanne B. Nicholas, Lu-Xi Zou

Diabetic kidney disease (DKD), defined as chronic kidney disease (CKD) attributed to diabetes mellitus (DM), is the leading cause of end-stage renal disease (ESRD) and is associated with increased... more

Extreme anemia (hemoglobin < 5 G/DL) at the emergency department

8 September 2023
Author(s): Sami Mustajoki, Anttimikael Heikkilä

Dear Editor,

Exploring sarcoidosis systemic treatment: Patient factors and therapeutic strategies

7 September 2023
Author(s): Rafiqur Rahman, FNU Samiullah, Satesh Kumar

Dear Editor,

Long-term efficacy and safety of secukinumab in patients with psoriatic arthritis

6 September 2023
Author(s): Aysal Mahmood, Abraish Ali, Hoorain Haider, Beenish Zulfiqar

Psoriatic arthritis (PsA) is a chronic inflammatory autoimmune disease that can adversely affect functional capabilities, if left untreated, leading to irreparable damage to joint spaces [1].... more

Dosing of iodixanol for predicting acute kidney injury in patients undergoing elective percutaneous coronary intervention

5 September 2023
Author(s): Zaiyan Chen, Ning Zhao, Yan Zhang, Ranzun Zhao, Xiaohui Zhao

A dose of iodinated contrast over the maximum allowable contrast dose (MACD) of 300 mL has been considered as a major factor leading to acute kidney injury (AKI) [1]. However, we found that the... more

Original Article

Anticoagulation strategies and long-term recurrence in patients with venous thromboembolism in the era of direct oral anticoagulants

11 August 2023
Author(s): Kazuhisa Kaneda, Yugo Yamashita, Takeshi Morimoto, Ryuki Chatani, Yuji Nishimoto, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Shuhei Tsuji, Maki Oi, Takuma Takada, Kazunori Otsui, Takeshi Kimura, COMMAND VTE Registry-2 Investigators

Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is a major health problem all over the world [1]. VTE has a long-term risk of recurrence, and the... more

Haemoglobin levels as a predictor for the occurrence of future cardiovascular events in adults–Sex-dependent results from the EPIC trial

8 August 2023
Author(s): Christian Jung, Ralf Erkens, Patricia Wischmann, Kerstin Piayda, Malte Kelm, Gunter Kuhnle

Anemia, defined by the World Health Organization (WHO) as hemoglobin (HGB) levels

Elevated levels of IL-6 in IgA nephropathy patients are induced by an epigenetically driven mechanism modulated by viral and bacterial RNA

5 August 2023
Author(s): Fabio Sallustio, Angela Picerno, Maria Teresa Cimmarusti, Francesca Montenegro, Claudia Curci, Giuseppe De Palma, Carmen Sivo, Francesca Annese, Giulia Fontò, Alessandra Stasi, Francesco Pesce, Silvio Tafuri, Vincenzo Di Leo, Loreto Gesualdo

Immunoglobulin A nephropathy (IgAN), also known as Berger's disease, is the most frequent primary glomerulonephritis characterized by the presence of IgA immune complexes in the glomeruli [1]. It... more

Clinical features and immune mechanisms directly linked to the altered liver function in patients with rheumatoid arthritis

4 August 2023
Author(s): I Arias-de la Rosa, M Ruiz-Ponce, L Cuesta-López, C Pérez-Sánchez, F Leiva-Cepas, MD Gahete, P Navarro, R Ortega, J Cordoba, E Pérez-Pampin, A González, AJ Lucendo, E Collantes-Estévez, Ch López-Pedrera, A Escudero-Contreras, N Barbarroja

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that mainly affects the synovial membrane, cartilage, and bone tissue, and is associated with progressive disability, systemic... more

Performance of admission pathways within acute medicine services: Analysis from the Society for Acute Medicine Benchmarking Audit 2022 and comparison with performance 2019 - 2021

3 August 2023
Author(s): Catherine Atkin, Thomas Knight, Tim Cooksley, Mark Holland, Chris Subbe, Adrian Kennedy, Ragit Varia, Adnan Gebril, Daniel Lasserson

Healthcare services are under huge strain, with rising Emergency Department (ED) attendances, increased waiting times for ED assessment and increasing pressures within inpatient services in acute... more

Relationships between education and non-alcoholic fatty liver disease

2 August 2023
Author(s): Florian Koutny, Elmar Aigner, Christian Datz, Sophie Gensluckner, Andreas Maieron, Andrea Mega, Bernhard Iglseder, Patrick Langthaler, Vanessa Frey, Bernhard Paulweber, Eugen Trinka, Bernhard Wernly

Affecting up to 30% of the adult population in western countries, non-alcoholic fatty liver disease (NAFLD) is a worldwide public health problem [1,2]. Because 5% of individuals with NAFLD suffer... more

Short-term prognosis of changes in plasma potassium following an episode of hyperkalaemia in patients with chronic heart failure

28 July 2023
Author(s): Sofie Solhøj Jønsson, Sofie Amalie Sørensen, Sidse Thim Krøgh, Dorte Melgaard, Peter Søgaard, Marc Meller Søndergaard, Peter Leutscher, Kristian Kragholm, Mette Aldahl, Christian Torp-Pedersen, Maria Lukács Krogager

Chronic heart failure (HF) is an increasing problem in public healthcare and is associated with considerable morbidity and mortality [1]. HF affects approximately 23 million people worldwide,... more

Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohort

28 July 2023
Author(s): Viktoria Santner, Hermann S. Riepl, Florian Posch, Markus Wallner, Peter P. Rainer, Klemens Ablasser, Ewald Kolesnik, Viktoria Hoeller, David Zach, Nora Schwegel, Philipp Kreuzer, Andreas Lueger, Johannes Petutschnigg, Burkert Pieske, Andreas Zirlik, Frank Edelmann, Nicolas Verheyen

Heart failure with preserved (HFpEF) and mildly reduced ejection fraction (HFmrEF) account for more than half of all heart failure decompensations [1]. Patients are exposed to a high risk of... more

Predicting acute and long-term mortality in a cohort of pulmonary embolism patients using machine learning

22 July 2023
Author(s): Wahbi K. El-Bouri, Alexander Sanders, Gregory Y.H. Lip, BBC-VTE investigators

Venous thromboembolism (VTE), including both pulmonary embolism (PE) and deep vein thrombosis (DVT), is a severe condition that causes significant mortality and morbidity in the acute phase, with a... more

Review Article

Atrial cardiomyopathy: An entity of emerging interest in the clinical setting

26 October 2023
Author(s): Giuseppe Boriani, Luigi Gerra, Marta Mantovani, Enrico Tartaglia, Davide A Mei, Jacopo F Imberti, Marco Vitolo, Niccolò Bonini

Since 1995, the concept of atrial cardiomyopathy (ACM) has been associated with myocardial fibrosis. Despite a consensus document in 2016, ACM's definition primarily relies on histopathological... more

A novel risk factor for malignancy: Albuminuria

22 September 2023
Author(s): Mehmet Kanbay, Sidar Copur, Zeynep Y. Yilmaz, Cem Tanriover, Nuri Baris Hasbal, Alberto Ortiz, Mark A. Perazella

Cancer is a global health concern with 23.6 million new cases globally in 2019, a 26.2 % increase from 2010 [1]. It is the second leading cause of death in adults after cardiovascular diseases,... more

What changed after the 2022 guidelines for pulmonary hypertension?

4 September 2023
Author(s): Mona Lichtblau, Anna Titz, Barbara Bahrampoori, Mark Schmiedeskamp, Silvia Ulrich

With an estimated prevalence of around 1%, pulmonary hypertension (PH) presents a relevant burden worldwide. The revised European Society of Cardiology (ESC) /European Respiratory Society (ERS)... more

Cannabidiol's impact on drug-metabolization

3 August 2023
Author(s): Claudia Stöllberger, Josef Finsterer

Cannabis and cannabis-derived substances are worldwide the most frequently consumed psychopharmaceuticals [1]. Over the past decade, attitudes toward the recreational and medicinal use of cannabis... more


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