Published: 18 September 2014
Author(s): Ferit Kerim Kucukler, Gulhan Akbaba, Ayse Arduc, Yasin Simsek, Serdar Guler
Section: Letter to the Editor

Hypothyroidism is a common disorder [1] whose diagnosis frequency has gradually risen. Although synthetic thyroxine (T4), L-triiodothyronine (T3), and T3/T4 combinations are available for correction of hypothyroidism, the treatment of choice is T4 alone for the vast majority of patients. The bioavailability of a drug depends on many factors such as drug disintegration and dissolution, time of drug intake, storage conditions, diet, and the tablet's size. The T4 is recommended to be taken as a single dose with a glass of water, preferably on an empty stomach, at least 0.5h to 1h before breakfast.


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