Published: 20 February 2020
Author(s): Fausto Salaffi, Marina Carotti, Marika Tardella, Marco Di Carlo, Paolo Fraticelli, Colomba Fischetti, Andrea Giovagnoni, Armando Gabrielli
Section: Original article

Systemic sclerosis (SSc) is a connective tissue disease characterized by extensive skin fibrosis and abnormalities in large and small vessels. Although cutaneous manifestations are the most frequent sign of the disease, there may be involvement of internal organs, particularly the lungs, with a severe impact on prognosis [1,2]. Interstitial lung disease (ILD) is the most frequent manifestation of lung involvement, with a prevalence of 53% of cases with diffuse SSc and 35% of cases with limited SSc [3].


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