Published: 22 October 2014
Author(s): Altan Onat, Tuğba Akbaş, Hüsniye Yüksel
Section: Letter to the Editor

The study by Mayer Jr. and associates [1] investigating the relationship between impaired glucose metabolism and lipoprotein-associated phospholipase A2 activity (aLp-PLA2) contributes to current knowledge. In a cross-sectional analysis of 825 patients with stable coronary heart disease (CHD) and/or stroke, they observed inverse relationships of aLp-PLA2 with high fasting glycemia, glycated hemoglobin A1c and with quartiles of LDLc/apoB ratio. Authors concluded that the presence of diabetes was independently associated with lower likelihood of elevated aLp-PLA2 and postulated a redistribution of aLp-PLA2 from apoB to high-density lipoprotein particles to account for their observation.


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