Published: 30 December 2019
Author(s): Maria E. Rodríguez-Ortiz, Juan F. Alcalá-Díaz, Antonio Canalejo, José D. Torres-Peña, Francisco Gómez-Delgado, Juan R. Muñoz-Castañeda, Javier Delgado-Lista, Mariano Rodríguez, José López-Miranda, Yolanda Almadén
Issue: January 2020
Section: Original article

The fibroblast growth factor 23 (FGF23) is a hormone produced mainly by bone cells that plays a fundamental role in the regulation of mineral metabolism through acting on different key actors [1]. Both phosphate excess and high calcitriol stimulate the production of FGF23. FGF23 favors phosphaturia by inhibiting tubular resorption of phosphate and reduces phosphatemia by decreasing calcitriol production through the inhibition and the activation of 1alpha-hydroxylase and 24-hydroxylase activities, respectively; thereby resulting in decreased intestinal phosphate absorption.


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