January 2021

58 Articles

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Anticoagulation dosing in atherosclerotic cardiovascular disease: Is less more?

16 December 2020
Author(s): Alexander C. Fanaroff, Renato D. Lopes

Pivotal randomized clinical trials (RCTs) conducted in the 1970s and 1980s comparing aspirin with placebo in patients with prior myocardial infarction established antithrombotic agents as mainstays... more

Lower dose direct oral anticoagulants and improved survival: A combined analysis in patients with established atherosclerosis

3 November 2020
Author(s): Riccardo Cappato, Mauro Chiarito, Michela Giustozzi, Martina Briani, Hussam Ali, Letizia Riva, Gianluca Bonitta, Corrado Lodigiani, Francesco Furlanello, Cristina Balla, Pierpaolo Lupo, Giulio Stefanini

Anti-thrombotic and anti-coagulation effects of direct oral anticoagulants (DOACs) are dose-dependent [1–5]. Conversely, the benefit from higher dose DOACs is counterbalanced by a dose-dependent risk... more

Disease- and gender-related characteristics of coeliac disease influence diagnostic delay

28 September 2020
Author(s): Marco Vincenzo Lenti, Antonio Di Sabatino

Coeliac disease is a high-prevalent, immune-mediated, chronic enteropathy caused by the ingestion of gluten in genetically susceptible individuals [1,2]. From the clinical viewpoint, coeliac disease... more

The 2020 International Society of Hypertension global hypertension practice guidelines - key messages and clinical considerations

22 September 2020
Author(s): Paolo Verdecchia, Gianpaolo Reboldi, Fabio Angeli

The International Society of Hypertension (ISH) has recently developed practice guidelines for the management of hypertension in adults aged ≥18 years. Conceptually, the 2020 ISH Guidelines are... more

Predicting spontaneous conversion to sinus rhythm in symptomatic atrial fibrillation: The ReSinus score

17 September 2020
Author(s): Jan Niederdöckl, Alexander Simon, Filippo Cacioppo, Nina Buchtele, Anne Merrelaar, Nikola Schütz, Sebastian Schnaubelt, Alexander O Spiel, Dominik Roth, Christian Schörgenhofer, Harald Herkner, Hans Domanovits, Michael Schwameis

In patients with symptomatic atrial fibrillation rates of spontaneous conversion are high.1-3 In real-world emergency cohorts optimal management is unclear; however, treatment with early... more


Sodium: sign, signifier, or signified, of sepsis?

16 December 2020
Author(s): Mai O'Sullivan, Kevin F McCarthy

85% of the known universe is made up of something we cannot directly observe as it does not absorb, emit, or reflect light. We can only infer the existence of dark matter through its effects on... more

Increasing the impact of Post Authorisation Safety Studies: transparency is key

1 December 2020
Author(s): Xavier Kurz, Peter Arlett, Hans-Georg Eichler, Alexis Nolte, Sabine Straus, Guido Rasi

In ETNA VTA Europe: A contemporary snapshot of patients treated with edoxaban in clinical practice across eight European countries, Cohen et al. report the results of a non-interventional drug... more

Hydroxychloroquine for COVID-19: Balancing contrasting claims

23 November 2020
Author(s): Peter W. Horby, Jonathan R. Emberson

The place of hydroxychloroquine in the prevention and treatment of COVID-19 has been controversial, with contrasting claims and high-emotions. It was initially proposed as treatment or prophylaxis... more

Large-scale use of hydroxychloroquine for COVID-19 confirms safety, if not effectiveness

28 October 2020
Author(s): Giulio Cavalli, Lorenzo Dagna

In this issue of the Journal, Di Castelnuovo and colleagues report the findings of the observational multicentre Italian CORIST Study on the use of hydroxychloroquine (HCQ) in hospitalised COVID-19... more

Venous thromboembolism and COVID-19: Mind the gap between clinical epidemiology and patient management

22 October 2020
Author(s): Michela Giustozzi, Maria Cristina Vedovati, Giancarlo Agnelli

Since the beginning of the coronavirus disease-2019 (COVID-19) pandemic, a compelling evidence of the association between this infection and an increased risk of venous thromboembolism has drawn the... more

Hypertension guidelines: Managing the differences or the patients?

19 October 2020
Author(s): AJ Manolis, LE Poulimenos, MS Kallistratos

Clinical guidelines summarize and evaluate all evidence available on a topic, with the aim of assisting physicians in selecting the best diagnostic and therapeutic strategies for an individual... more

Does hydroxychloroquine reduce mortality for COVID-19?

16 October 2020
Author(s): Silvano GALLUS, Antonio CLAVENNA, Alessandra LUGO

A paper published in this issue of the European Journal of Internal Medicine shows results from the COVID-19 RISK and Treatments (CORIST) Collaboration Study [1]. The authors analysed data from a... more

Utilize the full potential of real world evidence

7 October 2020
Author(s): Rupert Bauersachs

After the pivotal phase 3 trials on venous thromboembolism (VTE) treatment with non-vitamin K antagonist oral anticoagulants (NOACs) had been performed some 10 years ago, these drugs have now become... more

European Journal of Internal Medicine: IM Flashcards

Atypical chest pain with precordial T wave inversions

10 October 2020
Author(s): Leah Weston, Hani Alkhatib, Susrutha Kotwal

A 74-year-old woman with a prior history of coronary artery disease presented to the emergency department with intermittent, burning epigastric pain. Five months prior, she had a stress... more

Internal Medicine Flashcard

Bilateral foot drop and cherry skin lesion

21 November 2020
Author(s): Chen Fei Ng, Rabani Remli

A 34-year-old woman with no previous medical history presented with bilateral lower limbs weakness and numbness for three months. It was progressively worsening that she required wheelchair for... more

Spontaneous discoloration of the finger in a 67-year-old woman

18 November 2020
Author(s): Hiroaki Nakagawa, Yasushi Miyata

A 67-year-old woman presented to our clinic because she had developed spontaneous pain and purple discoloration of the fourth finger of her right hand that had started the previous day. She had... more

Chronic urticaria with inflammation

15 November 2020
Author(s): Hiroshi Hori, Takahiko Fukuchi, Hitoshi Sugawara

A 67-year-old man presented with a 15-year history of chronic urticaria. It was distributed symmetrically on the limb trunk (Fig. 1A and B) without pruritus. No fever or joint pain or headache is... more

Bright liver: a surprise discovery

29 September 2020
Author(s): Daisuke Murakami, Hideaki Harada, Yuji Amano

A 69-year-old woman with hypothyroidism, alcoholic liver disease, coronary artery disease, ventricular arrhythmia requiring placement of an implantable cardioverter defibrillator, and end-stage renal... more

A middle-aged woman with acute onset of fever, altered mental status, and movement disorder

25 September 2020
Author(s): Yusaku Kajihara

A 60-year-old woman was admitted in the emergency room with acute onset of fever, altered mental status, and movement disorder. The patient had well-controlled type 2 diabetes mellitus with... more

Internal Medicine Flashcards

A middle-aged woman with numbness and weakness of the extremities

23 September 2020
Author(s): Keizo Tanitame

A 45-year-old woman presented to the neurology department with numbness and weakness of extremities, which had progressed during 3 months. The patient had tingling sensation in the left neck.... more

Disturbance of consciousness after postpartum hemorrhage

23 September 2020
Author(s): Keizo Tanitame, Chinatsu Akagi, Nobuyuki Kamaki

A 37-year-old woman with postpartum hemorrhage was transferred by ambulance to our hospital for emergency treatment. On arrival massive hemorrhage continued, and she developed tachycardia (130 beats/... more

Letter to the Editor

The COVID-19 burden for health care professionals: Results of a global survey

13 November 2020
Author(s): Matthias Schneider, Martin Altersberger, Christina Binder, Christian Hengstenberg, Thomas Binder

At the end of December 2019, a novel coronavirus (SARS-CoV-2) started to spread in the city of Wuhan, Hubei province in China, first described as novel coronavirus [1,2]. Meanwhile, the current COVID... more

End-Stage renal disease and 30-day mortality for adults with and without COVID-19

8 November 2020
Author(s): Stephanie L. Harrison, Benjamin J.R. Buckley, Elnara Fazio-Eynullayeva, Paula Underhill, Deirdre A. Lane, Gregory Y.H. Lip

Emerging evidence suggests that people with chronic kidney disease have a higher risk of severe infection with coronavirus disease 2019 (COVID-19) [1]. Furthermore, acute kidney injury is common... more

Time to speed up–the rate at which we correct hypernatremia

5 November 2020
Author(s): M. Jongejan, L.J. Vleming

Hypernatremia is a common electrolyte disorder. It is defined as a serum sodium concentration > 145 mmol/L and is a hyperosmolar state in which there is a deficit in total body volume relative to... more

Temporal changes in co-morbidities and mortality in patients hospitalized for COVID-19 in Italy

30 October 2020
Author(s): Fabio Angeli, Tiziana Bachetti, for the Maugeri Study Group

In response to the growing pandemic of Coronavirus Disease 2019 (COVID-19) in Italy, the Italian government imposed a strict nationwide quarantine which began on March 9, 2020. The restrictive... more

Disease course in patients with systemic autoimmune diseases: insights on the safety of immunosuppression during the SARS-CoV-2 outbreak in Italy

15 October 2020
Author(s): Devis Benfaremo, Lucia Perini, Valentina Marconi, Michele Maria Luchetti, Armando Gabrielli

From December 2019 the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for the Coronavirus Disease 2019 (COVID-19), has caused a pandemic, with over 28 million cases and... more

COMPASS vs PEGASUS approach in a comparative budget impact analysis.

10 October 2020
Author(s): Natale Daniele Brunetti, Luisa De Gennaro, Michele Correale, Riccardo Ieva, Francesco Santoro

The treatment of coronary artery disease (CAD), peripheral artery disease (PAD) and ischemic heart disease (IHD), has been radically modified in the recent past by the implementation of the results... more

Significant increase in the incidence of high-risk pulmonary embolism during the COVID-19 shutdown: The pandemic response causes serious collateral consequences

6 October 2020
Author(s): Paul Gressenberger, Thomas Gary, Reinhard B. Raggam, Andrea Borenich, Marianne Brodmann

When the novel coronavirus disease (COVID-19) started to spread globally in December 2019 and COVID-19 related deaths continued to increase rapidly [1], the World Health Organization (WHO) declared a... more

Is the 2020 Sampson equation the best formula for LDL-C estimation?

22 September 2020
Author(s): Federica Piani, Arrigo F.G. Cicero, Claudio Borghi, Sergio D’Addato, on behalf of the BLIP Study group

Dear Editor,

Trans-catheter valve implantation and patient outcomes: Focus on the kidney

24 August 2020
Author(s): Giuseppe Boriani, Salvo Arrotti, Davide Gabbieri, Paolo Magnavacchi, Fabio Alfredo Sgura

In 2012 the Kidney Disease Improving Global Outcomes organization published a guideline focused on the definition and management of acute kidney injury (AKI) [1] which became an important reference... more

Healthy and non healthy obese patients. The truth lies in the adipose tissue

19 August 2020
Author(s): E. Sanidas, Μ. Velliou, D. Papadopoulos, D. Iliopoulos, J. Barbetseas

Obesity is commonly correlated with metabolic complications such as insulin resistance, type 2 diabetes mellitus, dyslipidemia, arterial hypertension and metabolic syndrome that are significant risk... more

Cause of death and risk factors for mortality in AA amyloidosis: A French retrospective study

14 August 2020
Author(s): Alexandre Terré, Samuel Deshayes, Léa Savey, Gilles Grateau, Sophie Georgin-Lavialle

AA amyloidosis (AAA) is a major complication of chronic inflammation. It is the consequence of the deposition of fibrils of serum amyloid A protein (SAA) in tissues [1]. Lachman et al. prospectively... more

Renal failure after trans-catheter aortic valve implantation

7 August 2020
Author(s): Marianna Adamo, Salvatore Curello, Marco Metra

Trans-catheter aortic valve implantation (TAVI) is by now considered the treatment of choice in patients with severe and symptomatic aortic stenosis deemed at prohibitive or high surgical risk.... more

Patterns of anticoagulation for atrial fibrillation in cancer patients referred to cardio-oncological evaluation

5 August 2020
Author(s): Matteo Toma, Edlira Rrapaj, Paolo Spallarossa, Federico Guerra, Pietro Ameri

Prophylaxis of atrial fibrillation (AF)-related cardioembolism in oncology is often challenging [1]. The CHA2DS2-VASc score performs differently according to the presence or absence of cancer, with... more

Bowel resection reduces aortic pulse wave velocity in patients with ulcerative colitis. A longitudinal study

5 August 2020
Author(s): Luca Zanoli, Antonino Tuttolomondo, Giulio Geraci, Pietro Castellino

Ulcerative colitis (UC) is characterized by an involvement of the large bowel which leads to chronic systemic inflammation, increased aortic stiffness and reflected waves [1–4] and an excess of... more

Original Article

Non-classical clinical presentation at diagnosis by male celiac disease patients of older age

17 November 2020
Author(s): Ineke L. Tan, Sebo Withoff, Jeroen J. Kolkman, Cisca Wijmenga, Rinse K. Weersma, Marijn C. Visschedijk

Celiac disease (CeD) is a complex immune-mediated disease that occurs in ̴1–2% of the Caucasian population [1]. In patients with CeD, ingestion of gluten peptides that are present in barley, wheat... more

Hypernatremia and moderate-to-severe hyponatremia are independent predictors of mortality in septic patients at emergency department presentation: A sub-group analysis of the need-speed trial

5 November 2020
Author(s): Luigi Mario Castello, Francesco Gavelli, Marco Baldrighi, Livia Salmi, Filippo Mearelli, Nicola Fiotti, Filippo Patrucco, Mattia Bellan, Pier Paolo Sainaghi, Giulia Ronzoni, Salvatore Di Somma, Enrico Lupia, Maria Lorenza Muiesan, Gianni Biolo, Gian Carlo Avanzi

Early risk stratification of septic patients admitted to the Emergency Department (ED) is challenging [1,2] since signs and symptoms may be similar for patients who will have either a favorable or an... more

Interleukin-6 receptor blockade with subcutaneous tocilizumab improves coagulation activity in patients with COVID-19

3 November 2020
Author(s): Marcello Di Nisio, Nicola Potere, Matteo Candeloro, Antonella Spacone, Leonardo Pieramati, Giovanna Ferrandu, Giulia Rizzo, Matteo La Vella, Silvio Di Carlo, Donatella Cibelli, Giustino Parruti, Marcel Levi, Ettore Porreca

A considerable proportion of patients with Coronavirus Disease 2019 (COVID-19) presents with a hypercoagulable state which may increase the risk of thromboembolic complications [1]. The most typical... more

Mobile health technology-supported atrial fibrillation screening and integrated care: A report from the mAFA-II trial Long-term Extension Cohort

13 October 2020
Author(s): Yutao Guo, Jun Guo, Xiangmin Shi, Yuan Yao, Yihong Sun, Yunlong Xia, Bo Yu, Tong Liu, Yundai Chen, Gregory Y H Lip, mAF-App II Trial investigators

The priorities of atrial fibrillation management include stroke prevention, decisions on rate or rhythm control and proactive management of comorbidities, as well as lifestyle changes. Given that... more

Sex-specific outcomes and management in critically ill septic patients

12 October 2020
Author(s): Bernhard Wernly, Raphael Romano Bruno, Behrooz Mamandipoor, Christian Jung, Venet Osmani

Sepsis is a life-threatening condition triggered by an “out-of-proportion” immune response to an infection [1]. Septic patients have low survival rates, and research to refine and individualize... more

Enterococcal infective endocarditis is a marker of current occult or future incident colorectal neoplasia

9 October 2020
Author(s): Maria Paola Ursi, Lorenzo Bertolino, Roberto Andini, Fabiana D'Amico, Domenico Iossa, Arta Karruli, Eugenio D'Avenia, Sabrina Manduca, Mariano Bernardo, Rosa Zampino, Emanuele Durante-Mangoni

Streptococcus gallolyticus and Enterococcus species are members of the gut microbiota and a major cause of infective endocarditis (IE), mainly affecting elderly subjects with digestive or urinary... more

Consumer-led screening for atrial fibrillation using consumer-facing wearables, devices and apps: A survey of health care professionals by AF-SCREEN international collaboration

12 September 2020
Author(s): Giuseppe Boriani, Renate B Schnabel, Jeff S Healey, Renato D Lopes, Nicole Verbiest-van Gurp, Trudie Lobban, John A Camm, Ben Freedman

Atrial fibrillation (AF) is the most common sustained arrhythmia diagnosed in clinical practice, with an incidence that increases in the elderly [1,2] and a prevalence of diagnosed AF that is... more

Long-term effects of non-retrieved inferior vena cava filters on recurrences of venous thromboembolism in cancer and non-cancer patients: From the COMMAND VTE registry

10 September 2020
Author(s): Toru Takase, Yoshitaka Iwanaga, Yugo Yamashita, Takeshi Morimoto, Yusuke Yoshikawa, Hidewo Amano, Seiichi Hiramori, Kitae Kim, Maki Oi, Yohei Kobayashi, Yuji Nishimoto, Heitaro Watanabe, Kenji Yamaji, Ryobun Yasuoka, Masafumi Ueno, Kazuhiro Kobuke, Takeshi Kimura, Shunichi Miyazaki, COMMAND VTE Registry Investigators

There is a paucity of data comparing the long-term outcomes after inferior vena cava (IVC) filters placement for patients with acute venous thromboembolism (VTE) between those with and without active... more

Impact of non-selective ß-blockers on hepatic encephalopathy in patients with liver cirrhosis

29 August 2020
Author(s): Christian Labenz, Michael Nagel, Gerrit Toenges, Robert Kuchen, Jörn M. Schattenberg, Max Hilscher, Yvonne Huber, Jens U. Marquardt, Joachim Labenz, Peter R. Galle, Marcus-Alexander Wörns

Liver cirrhosis accounts for over one million deaths per year worldwide [1]. Hepatic encephalopathy (HE) - one of its most severe complications - is a brain dysfunction mainly caused by liver... more

Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study

25 August 2020
Author(s): The COVID-19 RISK and Treatments (CORIST) Collaboration

Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19.

Definition of tachycardia for risk stratification of pulmonary embolism

23 August 2020
Author(s): Lukas Hobohm, Cecilia Becattini, Matthias Ebner, Markus H. Lerchbaumer, Franco Casazza, Gerd Hasenfuß, Stavros V. Konstantinides, Mareike Lankeit

Acute pulmonary embolism (PE) is the most serious manifestation of venous thromboembolism (VTE) and a major cause of mortality, morbidity and hospitalization in Western countries [1]. Acute right... more

Gastric regurgitation predicts neurological outcome in out-of-hospital cardiac arrest survivors

22 August 2020
Author(s): Anton Früh, Georg Goliasch, Raphael Wurm, Henrike Arfsten, Stefan Seidel, Lukas Galli, Lukas Kriechbaumer, Pia Hubner, Gottfried Heinz, Fritz Sterz, Christopher Adlbrecht, Klaus Distelmaier

Neurological prognostication after out-of-hospital cardiac arrest (OHCA) is challenging due to the lack of early and reliable predictors for clinically relevant brain damage [1]. The identification... more

Screening for nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography - a prospective, cross sectional study

21 August 2020
Author(s): I Mikolasevic, V Domislovic, T Turk Wensveen, B Delija, M Klapan, T Juric, A Lukic, A Mijic, N Skenderevic, P Puz, A Ostojic, Z Krznaric, D Radic-Kristo, T Filipec Kanizaj, D Stimac

The number of people suffering from type 2 diabetes (T2DM) and obesity around the world has significantly increased during the past several decades due to changes in eating habits and sedentary... more

Prognostic impact of Vitamin D deficiency in patients with coronary artery disease undergoing percutaneous coronary intervention

20 August 2020
Author(s): Monica Verdoia, Matteo Nardin, Roberta Rolla, Federica Negro, Rocco Gioscia, Arraa Maddalena Saghir Afifeh, Filippo Viglione, Harry Suryapranata, Marco Marcolongo, Giuseppe De Luca, Novara Atherosclerosis Study Group (NAS)

Vitamin D (25(OH)D) is a fat-soluble vitamin, representing not only the principal modulator of calcium and bone homeostasis, but also a key-hormone, regulating the transcription of about 2000 to 8000... more

How many urinalysis and urine cultures are necessary?

20 August 2020
Author(s): Bart J. Laan, Tessa M.Z.X.K. van Horrik, Prabath W.B. Nanayakkara, Suzanne E. Geerlings

Low-value care is defined as a test or treatment that is unlikely to benefit the patient given the cost, available alternatives, and preferences of patients, [1] and can even cause harm to patients [... more

ETNA VTE Europe: A contemporary snapshot of patients treated with edoxaban in clinical practice across eight European countries

18 August 2020
Author(s): Alexander T. Cohen, Ulrich Hoffmann, Philippe Hainaut, Sean Gaine, Cihan Ay, Michiel Coppens, Marc Schindewolf, David Jimenez, Bernd Brüggenjürgen, Pierre Levy, Petra Laeis, Eva-Maria Fronk, Wolfgang Zierhut, Thomas Malzer, Marius Constantin Manu, Paul-Egbert Reimitz, Peter Bramlage, Giancarlo Agnelli, ETNA-VTE-Europe investigators

Venous thromboembolism (VTE) encompasses both deep vein thrombosis (DVT) and pulmonary embolism (PE). It has an incidence of approximately 1–2 per 1,000 person-years in Europe [1]. While both events... more

Pharmacist-driven medication recognition/ reconciliation in older medical patients

7 August 2020
Author(s): Maria Teresa Chiarelli, Stefania Antoniazzi, Laura Cortesi, Luca Pasina, Alessio Novella, Francesca Venturini, Alessandro Nobili, Pier Mannuccio Mannucci, the ad hoc Deprescribing Study Group

Older patients, the largest fraction of those acutely admitted to hospital medical wards, are often affected by multiple chronic diseases, that are in turn associated with the intake of multiple... more

Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome

22 July 2020
Author(s): Marco Centola, Alessandro Maloberti, Diego Castini, Simone Persampieri, Ludovico Sabatelli, Giulia Ferrante, Stefano Lucreziotti, Nuccia Morici, Alice Sacco, Fabrizio Oliva, Paola Rebora, Cristina Giannattasio, Antonio Mafrici, Stefano Carugo

High levels of serum uric acid (SUA) have been showed to increase the risk of cardiac adverse events, independently of traditional cardiovascular risk factors [1,2]. Hyperuricemia has been also... more

The CHA2DS2-VASc score and Geriatric Multidimensional Assessment tools in elderly patients with persistent atrial fibrillation undergoing electrical cardioversion. A link with arrhythmia relapse?

22 July 2020
Author(s): Stefano Fumagalli, Giulia Pelagalli, Riccardo Franci Montorzi, Irene Marozzi, Marta Migliorini, Maria Flora D'Andria, Gregory Y.H. Lip, Niccolò Marchionni

The CHA2DS2-VASc is a clinical score used in everyday clinical practice to evaluate thrombo-embolic risk in patients with atrial fibrillation (AF) [1], and the guidelines for the management of AF... more


Multiparametric assessment of “fluid status” in heart failure

15 November 2017
Author(s): Giuseppe Romano, Diego Bellavia, Francesco Clemenza

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.ejim.2017.09.016. The duplicate article has therefore... more

Review Article

How does SARS-CoV-2 targets the elderly patients? A review on potential mechanisms increasing disease severity

30 November 2020
Author(s): Annemieke Smorenberg, Edgar JG Peters, Paul LA van Daele, Esther J Nossent, Majon Muller

On November 18th 2020, there have been over 55 million confirmed cases of SARS-CoV-2 infection causing COVID-19, with up to 1.3 million deaths worldwide. In the Netherlands alone, there are up to 8,... more

Transthyretin amyloid cardiomyopathy: An uncharted territory awaiting discovery

5 October 2020
Author(s): Aldostefano Porcari, Marco Merlo, Claudio Rapezzi, Gianfranco Sinagra

Amyloidosis represents a largely unexplored field in medicine, with many grey areas remaining. The search for the mechanism triggering protein misfolding has been an important research topic for many... more

Incidence of acute pulmonary embolism in COVID-19 patients: Systematic review and meta-analysis.

17 September 2020
Author(s): Loris Roncon, Marco Zuin, Stefano Barco, Luca Valerio, Giovanni Zuliani, Pietro Zonzin, Stavros V Konstantinides

The outbreak of coronavirus disease 2019 (COVID-19) remains a severe public health emergency of international concern. Over the past months, several investigations have suggested an association... more


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