Thrombocytopenia in cancer patients with an indication for anticoagulation is not uncommon [1], and poses a unique clinical challenge. Clinical trials evaluating anticoagulants for treatment of venous thromboembolism (VTE) excluded patients with thrombocytopenia [2-4]. As a result, management is informed mainly by expert opinion [5] and limited retrospective cohort studies on VTE, as recently reviewed [6]. In this setting, anticoagulation can be held or continued at full or reduced doses, with or without platelet transfusion support.