Published: 29 May 2020
Author(s): Miriana d'Alessandro, Elena Bargagli
Issue: July 2020
Section: Commentary

In the current issue of the European Journal of Internal Medicine, we read with interest a new cluster-analysis to distinguish clinical phenotypes of sarcoidosis [1]. Six phenotype clusters emerged by combining traditional signs and symptoms. This approach is a further attempt to classify this chronic multisystemic disease of unknown origin and heterogeneous clinical presentation. Phenotyping sarcoidosis patients is important for clarifying prognosis and therapeutic approaches. The clinical course of sarcoidosis is unpredictable: spontaneous remission is reported in more than 50% of patients; many others develop acute Löfgren syndrome (LS).


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