Published: 27 September 2014
Author(s): Maurizio Pandolfi, Giulia Carreras
Section: Letter to the Editor

We do not doubt that “Millions of patients experience an effect of CAM, often after conventional medicine failed”, as Rutten and Stolper say [1]. The question, as our paper maintains [2], is whether this improvement is due to the specific efficacy of the intervention or to other causes like placebo effect and/or spontaneous regression of the disease. And this crucial question cannot be answered without the help of a meaningful inferential statistics.


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