May 2017

37 Articles

No Section

Nation-based case-control study investigating the relationship between oral corticosteroids use and pulmonary tuberculosis

26 May 2017
Author(s): Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao

No published formal study focuses on the relationship between oral corticosteroids use and pulmonary tuberculosis in Taiwan. The aim of the study was to investigate whether oral corticosteroids use... more

Geoepidemiology, clinical manifestations and outcome of primary biliary cholangitis in Greece

20 May 2017
Author(s): Nikolaos K. Gatselis, Kalliopi Zachou, Vasiliki Lygoura, Kalliopi Azariadis, Pinelopi Arvaniti, Elias Spyrou, Georgia Papadamou, George K. Koukoulis, George N. Dalekos, Eirini I. Rigopoulou

Primary biliary cholangitis (PBC) is a disease with rising prevalence and considerable geographical variation. To describe the prevalence, spatial and time distribution, baseline characteristics,... more

Advances in alternative non-animal testing methods represent a way to find new treatments for patients

15 May 2017
Author(s): Lindsay J. Marshall, Andrew N. Rowan

On behalf of the Humane Society of the United States and the Humane Society International, we would like to respond to the recent publication in your journal [1]. This article claims that animal... more

Case Report

When the diagnosis is written on the forehead

6 May 2017
Author(s): Federico Pasin, Simone Bonardi, Antonio Modoni

An 81year-old man with a medical history of smoking, mild alchool intake, hypertension and diabetes, presented to the Internal Medicine Unit with 4cm soft, well demarcated, painless swelling of the... more

Internal Medicine Flashcard

Purpuric lesions in a 45-year old man

22 May 2017
Author(s): Broner Jonathan, Reymann Valérie, Guilpain Philippe

A forty-five year-old man, with a tobacco and alcohol history, affected with Crohn's disease, was admitted for haemoptysis and abdominal pain. The clinical examination showed extensive cutaneous... more

A 33year-old woman with calciphylaxis, diabetic kidney disease and abdominal pain

13 May 2017
Author(s): Denise Sanchez, Anh Phan, Emil Lesho

A 33year-old female with diabetes mellitus type 2 and stage four chronic kidney disease presented to the emergency department with altered mental status and severe abdominal pain. Three months prior... more

A young woman with fever and low visual acuity

13 May 2017
Author(s): Leticia Urbina Soto, Alicia López de Eguileta Rodríguez, Santiago Echevarria Vierna

A 38-year-old woman with no particular medical history was referred to our hospital for low-grade fever and polyarthralgias since 15–20days ago. She revealed a history of contact with cats at home... more

Asteroid Hyalosis

13 May 2017
Author(s): Daniel Gologorsky, Oriel Spierer

A 49year-old diabetic man presented to the ophthalmology clinic to establish care. After refraction, his best-corrected visual acuities were 20/25 in both eyes. Dilated fundus examination showed a... more

A man with dyspnea, chest pain and leukocytosis

13 May 2017
Author(s): Evan L. Honig, Matthew D. Alvin

A 34-year-old male intravenous drug user presented with dyspnea, pleuritic chest pain, hemoptysis, and bilateral lower extremity swelling. His initial vitals were temperature 38.8°C, heart rate 100/... more

Fever, arthritis, and cutaneous lesions

5 May 2017
Author(s): Claude Bachmeyer, Agathe Vigouroux, Philippe Moguelet

A previously healthy 41-year-old man presented with a 5-day history of fever, arthritis, and cutaneous lesions. The patient denied any treatment, did not use alcohol or illicit drug. On physical... more

A cystic splenic mass in a farmer

4 May 2017
Author(s): Satish B. Rao, Deepak R. Madi, Avinash K. Shetty

A 60-year old farming woman presented with a 2-day history of fever, left upper quadrant abdominal pain and vomiting. On examination, the patient had a temperature of.

Widespread painful nodules in a patient with rheumatoid arthritis

3 May 2017
Author(s): Devis Benfaremo, Michele Maria Luchetti, Armando Gabrielli

A 60-year-old woman affected by rheumatoid arthritis (RA) reported a 12-month history of progressive growth of multiple, painful and symmetrically distributed subcutaneous nodules affecting forearms... more

Letter to the Editor

Timing of syncope during blood sampling – The Maastricht Study

29 May 2017
Author(s): Remy J.H. Martens, Stefan L.C. Geijselaers, Coen D.A. Stehouwer, Ronald M.A. Henry, The Maastricht Study Group

Almost everyone who visits an internist will be subjected to venous blood sampling, either for diagnostic purposes or therapeutic follow-up. Likewise, blood sampling forms the cornerstone of most... more

ZIKA virus: A new threat to the eyes

29 May 2017
Author(s): Dhrubajyoti Bandyopadhyay, Adrija Hajra

Zika virus (ZIKV) infection is a great matter of concern globally. Though asymptomatic in the majority of cases, the effect of this virus on fetal growth has drawn attention. ZIKV is a positive-sense... more

Nurse-led vaccination program dramatically improves pneumococcal vaccination coverage among patients with autoimmune inflammatory disorders

26 May 2017
Author(s): Justine Serre, Chrystel François, Marie Claude Van der Haegen, Thomas Papo, Tiphaine Goulenok, Karim Sacre

Streptococcus pneumoniae infection is a major cause of morbidity and mortality in patients with autoimmune inflammatory disorders (AID) treated with immunosuppressive therapy [1–4]. Despite... more

Incremental cost-effectiveness ratio and net monetary benefit: Current use in pharmacoeconomics and future perspectives

25 May 2017
Author(s): Sabrina Trippoli

In evaluating the cost/effectiveness of therapeutic interventions (e.g. those based on innovative drugs or on Class-III medical devices), two main pharmacoeconomic parameters have been used over the... more

Person-centred analysis in Physician-Patient relationship

23 May 2017
Author(s): Ilario Stefani, Ornella Teti, Antonino Mazzone

Contemporary Medicine is characterized by an episteme based on complexity, promoted by the recognition of the inherent limit in science, despite impressive results in technology. This change refers... more

Is the six-minute walk test useful or useless in systemic sclerosis?

22 May 2017
Author(s): Pierachille Santus, Dejan Radovanovic, Francesca Frassanito, Andrea Cristiano, Maurizio Rizzi

Systemic sclerosis (SSc) is a multisystem and complex disease, with different classifications as well as different degrees of pulmonary involvement. SSc patients, and particularly those with a... more

Paroxysmal nocturnal hemoglobinuria with spontaneous clinical remission

18 May 2017
Author(s): Valeria Ferla, Anna Zaninoni, Bruno Fattizzo, Elisa Fermo, Umberto Gianelli, Wilma Barcellini

To the Editor, paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal disorder of hematopoietic stem cell characterized by chronic intravascular hemolytic anemia, thrombosis, bone marrow... more

Sex differences in association between decreased glomerular filtration rate and prolongation of corrected QT interval in general Chinese population

13 May 2017
Author(s): Zhao Li, Xiaofan Guo, Liang Guo, Liqiang Zheng, Shasha Yu, Hongmei Yang, Yonghong Zhang, Yingxian Sun

Cardiovascular disease (CVD) is the leading cause of death among chronic kidney disease (CKD) patients. It has been demonstrated that even minor degrees of renal dysfunction are associated with... more

Should subcutaneous implantable cardioverter-defibrillators be implanted in patients who are candidates for continuous flow left ventricular assist device?

12 May 2017
Author(s): Giuseppe Maria Raffa, Marco Morsolini, Giovanni Gentile, Giuseppe Coppola, Sergio Sciacca

Interaction between continuous-flow left ventricular assist device (CF-LVAD) and implantable cardioverter-defibrillator (ICD) is a debated issue. Inappropriate therapy due to ICD and CF-LVAD... more

Cartilage oligomeric matrix protein on the spot for liver fibrosis evaluation: Too early or too late?

11 May 2017
Author(s): Kalliopi Zachou, Stella Gabeta, Nikolaos K. Gatselis, Gary L. Norman, George N. Dalekos

We would like to thank Huang et al. [1] for their interest and valid comments regarding our recent study published in the March issue of the journal on the potential use of serum cartilage oligomeric... more

Criteria for frusemide reduction or withdrawal

8 May 2017
Author(s): Oscar M.P. Jolobe

The successful withdrawal of frusemide in 21 out of 190 patients with congestive symptoms attributable to systolic heart failure [1], corroborates the observation made by Oshima et al. that patients... more

Intolerance to roflumilast in real-life clinical practice

2 May 2017
Author(s): Mónica Gómez-Rodríguez, Rafael Golpe

Roflumilast is a selective phosphodiesterase-4 inhibitor, introduced for the treatment of chronic obstructive pulmonary disease (COPD) patients with symptoms of chronic bronchitis and frequent... more

Criteria for the choice of anticoagulant therapy for the prevention of stroke in patients with atrial fibrillation early after the marketing of direct oral anticoagulants in Italy

2 May 2017
Author(s): I. Marzona, M.C. Roncaglioni, F. Avanzini, M.G. Franzosi, M. Moia, members of an ad hoc study group

Atrial Fibrillation (AF) is the most common arrhythmia which is associated with an enhanced risk of stroke and mortality [1]. Oral anticoagulants (OACs) decrease the risk of thromboembolic stroke by... more

Narrative Review

Progress in the contemporary management of hemophilia: The new issue of patient aging

20 May 2017
Author(s): Pier Mannuccio Mannucci, Massimo Iacobelli

The management of inherited coagulation disorders such as hemophilia A and B has witnessed dramatic progresses since the last few decades of the last century. Accordingly, persons with hemophilia (... more

Chagas disease in Europe: A review for the internist in the globalized world

11 May 2017
Author(s): Spinello Antinori, Laura Galimberti, Roberto Bianco, Romualdo Grande, Massimo Galli, Mario Corbellino

Chagas disease (CD) or American trypanosomiasis identified in 1909 by Carlos Chagas, has become over the last 40years a global health concern due to the huge migration flows from Latin America to... more

Original Article

Characterization of circadian COPD symptoms by phenotype: Methodology of the STORICO observational study

31 May 2017
Author(s): G.W. Canonica, F. Blasi, N. Scichilone, L. Simoni, A. Zullo, C. Giovannetti, C. Briguglio, S. Barsanti, R. Antonelli Incalzi, STORICO study group

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. The symptoms of COPD are troublesome, variable, can occur during all parts of the 24-h... more

The contribution of clinical and pathological predisposing factors to severe gastro-duodenal lesions in patients with long-term low-dose aspirin and proton pump inhibitor therapy

31 May 2017
Author(s): Anca Negovan, Mihaela Iancu, Valeriu Moldovan, Kinga Sàrkàny, Simona Bataga, Simona Mocan, Ioan Țilea, Claudia Banescu

Preventive strategies developed to avoid the complications of antiplatelet therapies recommend the evaluation of risk factors for gastrointestinal events and indicated gastroprotective strategies.

Cardiometabolic healthy obesity paradigm and all-cause mortality risk

13 May 2017
Author(s): Paul D. Loprinzi, Emily Frith

To examine the cardiometabolic healthy obesity paradigm as it relates to all-cause mortality risk, with effect moderation evaluated for physical activity and demographic characteristics.

Women with atrial fibrillation and type 2 diabetes have a higher incidence of hospitalization and undergo ablation or pacemaker implantation less frequently than men

12 May 2017
Author(s): Manuel Méndez-Bailón, Nuria Muñoz-Rivas, Rodrigo Jiménez-García, Valentín Hernández-Barrera, José Mª. de Miguel-Yanes, Noel Lorenzo Villalba, Javier de Miguel Diez, Ana Lopez-de-Andrés

We reviewed trends from 2004 to 2013 in the incidence and outcomes for atrial fibrillation (AF) in Spanish patients with type 2 diabetes mellitus (T2DM) comparing women and men.

Screening for occult cancer in idiopathic venous thromboembolism — Systemic review and meta-analysis

11 May 2017
Author(s): Alina Klein, Daniel Shepshelovich, Galia Spectre, Hadar Goldvaser, Pia Raanani, Anat Gafter-Gvili

Idiopathic venous thromboembolism (VTE) may be associated with an occult malignancy. Early detection of cancer might be translated to a better prognosis for these patients. However, the efficacy of... more

Mortality in dialysis patients with cinacalcet use: A large observational registry study

10 May 2017
Author(s): Claudia Friedl, Gilbert Reibnegger, Reinhard Kramar, Emanuel Zitt, Stefan Pilz, Johannes F.E. Mann, Alexander R. Rosenkranz

Secondary hyperparathyroidism (sHPT) is associated with higher mortality in dialysis patients. The calcimimetic cinacalcet reduces intact parathyroid hormone (iPTH) in dialysis patients. The... more

Impact of prealbumin on mortality and hospital readmission in patients with acute heart failure

9 May 2017
Author(s): Jonathan Franco, Francesc Formiga, Joan-Carles Trullas, P. Salamanca Bautista, Alicia Conde, Luis Manzano, Raúl Quirós, Álvaro González Franco, Alejandro Martín Ezquerro, Manuel Montero-Pérez-Barquero, RICA investigators group

Prealbumin is a maker of nutritional status and inflammation of potential prognostic value in acute heart failure (HF). The aim of this study is to evaluate if low prealbumin levels on admission... more

Review Article

Interventions in type 2 diabetes mellitus and cardiovascular mortality–An overview of clinical trials

26 May 2017
Author(s): Benjamin Burggraaf, Manuel Castro Cabezas

Diabetes mellitus type 2 (T2DM) has been associated with an increased cardiovascular risk. Improving glycaemia or other traditional cardiovascular risk factors may reduce cardiovascular risk in... more

Clinical management of iron deficiency anemia in adults: Systemic review on advances in diagnosis and treatment

18 May 2017
Author(s): Lucia De Franceschi, Achille Iolascon, Ali Taher, Maria Domenica Cappellini

Global burden disease studies point out that one of the top cause-specific anemias is iron deficiency (ID). Recent advances in knowledge of iron homeostasis have shown that fragile patients are a new... more

What is inappropriate hospital use for elderly people near the end of life? A systematic review

11 May 2017
Author(s): Magnolia Cardona-Morrell, James C.H. Kim, Mikkel Brabrand, Blanca Gallego-Luxan, Ken Hillman

Older people with advance chronic illness use hospital services repeatedly near the end of life. Some of these hospitalizations are considered inappropriate.


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