We read the study of Calvania et al. with great interest titled “BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons” (BIOSPHERE): Rationale, design and methods” [1]. In this paper, the authors highlighted that sarcopenia was a major health issue in older adults given its high prevalence, and burdensome clinical implications. In addition to this unsolved debate, the complexity of musculoskeletal ageing represented a major challenge to the identification of clinically meaningful biomarkers.
