October 2021

32 Articles

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Detection of subclinical atrial fibrillation after cryptogenic stroke using implantable cardiac monitors

8 July 2021
Author(s): Andrea Ungar, Francesca Pescini, Martina Rafanelli, Maria Vittoria De Angelis, Massimiliano Faustino, Caterina Tomaselli, Alfredo Petrone, Giovanni Forleo, Giovanni Morani, Stefano Forlivesi, Giulio Molon, Alessandro Adami, Massimiliano Maines, Chiara Stegagno, Anna Poggesi, Leonardo Pantoni

Despite extensive vascular and cardiological evaluations, the etiology of approximately one third of ischemic strokes cannot be definitively identified, resulting in their classification as... more

Efficacy of Belimumab for refractory systemic lupus erythematosus (SLE) involving the central nervous system

2 July 2021
Author(s): Hao Cheng, Chen-sheng Zhao, Cheng-lan Yan, Chong Gao, Hong-yan Wen

Neuropsychiatric manifestations of SLE (NPSLE) is associated with increased morbidity and mortality, intractable, complicating, and poor prognosis [1–3]. Although the severity of NPSLE correlates... more

Device-detected atrial high rate episodes and the risk of stroke/thrombo-embolism and atrial fibrillation incidence: a systematic review and meta-analysis

19 June 2021
Author(s): Marco Vitolo, Jacopo F Imberti, Anna Maisano, Alessandro Albini, Niccolò Bonini, Anna Chiara Valenti, Vincenzo L Malavasi, Marco Proietti, Jeff S Healey, Gregory YH Lip, Giuseppe Boriani

Modern Cardiac Implantable Electronic Devices (CIEDs) allow continuous monitoring of cardiac electrical activity through one or more electrodes. Atrial High Rate Episodes (AHRE) are defined as device... more

Non-HACEK gram negative bacilli endocarditis: Analysis of a national prospective cohort.

9 May 2021
Author(s): Jorge Calderón Parra, Daniel De Castro-Campos, Patricia Muñoz García, Maria Olmedo Samperio, Mercedes Marín Arriaza, Aristides De Alarcón, Encarnación Gutierrez-Carretero, Maria Carmen Fariñas Alvarez, Jose María Miró Meda, Miguel Ángel Goneaga Sanchez, Raquel Rodriguez García, Guillermo Ojeda Burgos, Zeltia Valcarce-Gonzalez, Antonio Ramos-Martinez, the Spanish Collaboration on Infectious Endocarditis Group (GAMES) investigators

Infective endocarditis (IE) caused by Gram-negative bacilli (GNB) not included in the HACEK group (Haemophilus, Actinobacillus, Cardiobacterium, Eikenella corrodens, Kingella) is a rare infection... more


Standardised PaO2/FiO2 ratio in COVID-19: Added value or risky assumptions?

8 September 2021
Author(s): Luciano Gattinoni, Mattia Busana, Luigi Camporota

The coronavirus disease 2019 (COVID-19) causes acute respiratory failure (ARF) altering the pulmonary microvasculature with simultaneous vasoconstriction and thrombosis in ventilated areas,... more

New insights in endocarditis caused by Gram negative bacilli not included in the HACEK group

7 September 2021
Author(s): Ricardo Serrano, Jordi Rello

Gram negative bacilli not included in the HACEK group (Haemophilus, Aggregatibacter spp -including A. Actinomycetemcomitans, A. Aprophilus, A. Paraphrophilus, A. Segnis-, Cardiobacterium, Eikenella... more

Long term consequences of COVID-19

1 September 2021
Author(s): Anna Berenguera, Constanza Jacques-Aviñó, Laura Medina-Perucha, Diana Puente

On March 11, 2020, the coronavirus disease-2019 (COVID-19) was declared a pandemic by World Health Organization (WHO). While mainly affecting the respiratory system to the point of causing severe... more

Is coronary microvascular dysfunction a cause or a marker of worse outcomes in MINOCA patients?

7 July 2021
Author(s): Francesco Radico, Sabina Gallina, Marco Zimarino

Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) is a frequent clinical scenario observed in approximately 5% of all patients with acute myocardial infarction (AMI... more


Corrigendum to: Antipsychotics and severe hyponatremia: A Swedish population-based case-control study. Eur J Intern Med. 2019 Feb;60:71-77.

23 June 2021
Author(s): Henrik Falhammar, Jonatan D. Lindh, Jan Calissendorff, Jakob Skov, David Nathanson, Buster Mannheimer

The authors regret that in preparation of a new article based on the same data as in the previous published article [1], we unfortunately discovered two errors in the dataset. Some cases of... more

Corrigendum to: Tramadol- and codeine-induced severe hyponatremia: A Swedish population-based case-control study. Eur J Intern Med. 2019 Nov;69:20-24.

22 June 2021
Author(s): Henrik Falhammar, Jan Calissendorff, Jakob Skov, David Nathanson, Jonatan D. Lindh, Buster Mannheimer

The authors regret that in preparation of a new article based on the same data as in the previous published article[1], we unfortunately discovered two errors in the dataset. Some cases of... more


New insights in obesity development and possible value of microbiota transplantation

7 July 2021
Author(s): Hermann Toplak, Natascha Troester, Vanessa Stadlbauer

Obesity is possibly the most important non communicable disease of the 21st century. It has emerged from one of the “nutritional disorders” and has been suggested by the European Association for the... more

Ideas and Opinions

Exploring the possible link between myocarditis and mRNA COVID-19 vaccines

27 August 2021
Author(s): Gianfranco Sinagra, Marco Merlo, Aldostefano Porcari

Myocarditis is an inflammatory cardiomyopathy, most frequently caused by viral agents, affecting 10-20 individuals per 100.000 each year in the general population [1]. Myocarditis (sometimes... more

One year on: The impact of COVID-19 on clinical research

24 August 2021
Author(s): Luigi Tavazzi, Aldo P. Maggioni, Claudio Rapezzi, Roberto Ferrari

During COVID-19 epidemic ongoing clinical research slowed down while an unprecedented amount of individual research on the infection broke out disproportionately with results, low respect to the... more

Internal Medicine Flashcard

Facial hypertrichosis, hyperpigmentation, and hepatosplenomegaly

6 September 2021
Author(s): Paola E. Pizano, Edwin Uriel Suárez

A 51-year-old woman presented for evaluation of new-onset of facial hypertrichosis, hyperpigmentation and blistering on the back of the hands with sunlight exposure, additionally she referred change... more

Man with pruritic rash

31 August 2021
Author(s): Eleanor Burton, Susrutha Kotwal

A 41-year-old previously healthy man presented with a 3-day history of fevers, headache, abdominal pain, and pruritic rash. The rash began on his forehead and extended to the rest of his body. He had... more

A febrile patient with an unusual eruption

28 August 2021
Author(s): Hitaishi Mehta, Sheetanshu Kumar, Anuradha Bishnoi

A 45-year-old man presented to dermatology outpatient department with complaints of sudden-onset, painful, clustered, monomorphic, punched-out erosions and ulcers, distributed symmetrically in the... more

Lupus pernio: Skin manifestation of systemic disease

28 August 2021
Author(s): Narat Srivali, Federica De Giacomi

62-year-old woman presented to our institution with the chief complaint of slowly progressive exertional dyspnea over the preceding two years in conjunction with a cough and facial rash. Physical... more

Letter to Editor

Validation of Takayasu arteritis, polyarteritis nodosa and Behcet's disease diagnosis codes in a French hospital database

10 August 2021
Author(s): Camille Mettler, Samir Bouam, Laurent Chouchana, Benjamin Terrier

Dear Editor,

Letter to the Editor

Quality of life in patients with antiphospholipid antibodies differs according to antiphospholipid syndrome damage index (DIAPS)

27 July 2021
Author(s): Massimo Radin, Silvia Grazietta Foddai, Irene Cecchi, Dario Roccatello, Savino Sciascia

Antiphospholipid syndrome (APS) is an acquired thrombophilia characterized by the presence of confirmed antiphospholipid antibodies (aPL) positive testing with thrombotic events potentially occurring... more

Safety and efficacy of oral anticoagulants in atrial fibrillation and bioprosthetic heart valves

13 July 2021
Author(s): Srikanth Yandrapalli, Rahul Gupta, Aaqib H. Malik

Atrial fibrillation (AF) is commonly encountered in clinical practice by internists and specialists, both in the inpatient and ambulatory settings. AF increases the risk of stroke or systemic... more

Comparison of supervised exercise therapy with or without revascularization for the management of intermittent claudication

9 July 2021
Author(s): Rajkumar Doshi, Priyank Shah, Monil Majmundar, Ashish Kumar, Saraschandra Vallabhajosyula

Peripheral artery disease (PAD) affects about 8.5 million Americans aged ≥ 40 years and is associated with significant morbidity and mortality [1]. In patients with claudication, a supervised... more

Hyperhomocysteinemia in patients with acute porphyrias: a possible effect of ALAS1 modulation by siRNAm therapy and its control by vitamin supplementation

2 July 2021
Author(s): Andrea Ricci, Matteo Marcacci, Chiara Cuoghi, Antonello Pietrangelo, Paolo Ventura

Acute hepatic porphyrias (AHPs) are a group of rare diseases caused by an enzymatic dysfunction in the biosynthesis of heme [1]. AHPs’ clinical landmarks are recurrent crisis of neurovisceral attacks... more

Recognition of sepsis in the pre-hospital environment one year after intensive traineeship

24 June 2021
Author(s): L.I. Veldhuis, M.L. Ridderikhof, P.W.B. Nanayakkara, M.W. Hollmann

The mortality of sepsis patients presented by the Emergency Medical Services (EMS) with unrecognized sepsis is twice as high as in patients with documented sepsis [1]. To improve the (pre)-hospital... more

SHARPEN score accurately predicts in-hospital mortality in infective endocarditis

14 June 2021
Author(s): Sofia Giusti Alves, Fernando Pivatto Júnior, Filippe Barcellos Filippini, Gustavo Paglioli Dannenhauer, Marcelo Haertel Miglioranza

Infective endocarditis (IE) has a significant in-hospital mortality [1]. There is evidence of improved clinical outcomes with protocols based on disease severity [2]. In this context, score-based... more

Original Article

Standardizing PaO2 for PaCO2 in P/F ratio predicts in-hospital mortality in acute respiratory failure due to Covid-19: A pilot prospective study

16 June 2021
Author(s): Irene Prediletto, Letizia D'Antoni, Paolo Carbonara, Federico Daniele, Roberto Dongilli, Roberto Flore, Angela Maria Grazia Pacilli, Lara Pisani, Corina Tomsa, María Laura Vega, Vito Marco Ranieri, Stefano Nava, Paolo Palange

Up to fifteen percent of patients with novel pandemic coronavirus disease (Covid-19) have acute respiratory failure (ARF). Ratio between arterial partial pressure of oxygen (PaO2) and fraction of... more

Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis

15 June 2021
Author(s): César Fernández-de-las-Peñas, Domingo Palacios-Ceña, Víctor Gómez-Mayordomo, Lidiane L Florencio, María L. Cuadrado, Gustavo Plaza-Manzano, Marcos Navarro-Santana

The world is suffering a dramatic situation of catastrophic proportions due to the rapid worldwide spread of the coronavirus disease 2019 (COVID-19) caused by the pathogen acute respiratory syndrome... more

Clinical utility of antigen carbohydrate 125 for planning the optimal length of stay in acute heart failure

12 June 2021
Author(s): Miguel Lorenzo, Patricia Palau, Pau Llàcer, Eloy Domínguez, Bruno Ventura, Gonzalo Núñez, Gema Miñana, Javier Solsona, Enrique Santas, Rafael De La Espriella, Vicent Bodí, Eduardo Núñez, Juan Sanchis, Antoni Bayés-Genís, Julio Núñez

The optimal length of stay (LOS) in patients hospitalized for acute heart failure (AHF) remains uncertain [1]. Classically, more extended stays have been associated with a higher risk of in-hospital... more

Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction with non-obstructive coronary arteries

3 June 2021
Author(s): Fuad A. Abdu, Lu Liu, Abdul-Quddus Mohammed, Guoqing Yin, Bin Xu, Wen Zhang, Siling Xu, Xian Lv, Rui Fan, Cailin Feng, Tingting Shi, Yunlong Huo, Yawei Xu, Wenliang Che

Myocardial infarction with non-obstructive coronary arteries (MINOCA) at coronary angiography (CAG) (stenosis

Autologous fecal microbiota transplantation can retain the metabolic achievements of dietary interventions

18 April 2021
Author(s): Ehud Rinott, Ilan Youngster, Anat Yaskolka Meir, Gal Tsaban, Alon Kaplan, Hila Zelicha, Elad Rubin, Omry Koren, Iris Shai

We recently reported that autologous fecal microbiota transplantation (aFMT), derived from the time of maximal weight-loss and administrated in the regain-phase, might preserve weight loss and... more

Review Article

State of the art approach to managing angina and ischemia: tailoring treatment to the evidence

18 August 2021
Author(s): Manolis AJ, Boden WE, Collins P, Dechend R, Kallistratos MS, Lopez Sendon J, Poulimenos LE, Ambrosio G, Rosano G

Cardiovascular disease (CVD) is the most common cause of death and disability worldwide [1-5]. Stable angina represents a chronic, often life-long condition involving approximately 2% and 4% of the... more

Obesity and sleep disturbances: The “chicken or the egg” question

14 May 2021
Author(s): Gabriel Dias Rodrigues, Elisa M. Fiorelli, Ludovico Furlan, Nicola Montano, Eleonora Tobaldini

Since 1980 obesity has seen a rapid increase in global prevalence, that has almost doubled in many countries and nowadays affects more than 12% of the general population [1]. Interestingly, the rapid... more

Sweet taste and obesity

13 February 2021
Author(s): Gabriela Ribeiro, Albino J. Oliveira-Maia

Obesity is associated with significant morbidity and mortality, and currently represents a global health challenge[1]. While it is associated with complex pathophysiology, increased availability of... more


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