September 2021

28 Articles

No Section

Low bleeding and thromboembolic risk with continued dabigatran during cardiovascular interventions: the GLORIA-AF study

11 June 2021
Author(s): Sake J. van der Wall, Gregory Y.H. Lip, Christine Teutsch, Oskars Kalejs, Philippe Lyrer, Christian Hall, Sergio J. Dubner, Hans-Christoph Diener, Jonathan L. Halperin, Chang Sheng Ma, Kenneth J. Rothman, Kristina Zint, Dongmei Zhai, Menno V. Huisman, GLORIA-AF Investigators

Non vitamin-K-antagonist oral anticoagulants (NOACs) have emerged as preferred treatment over vitamin K antagonists (VKAs) for the prevention of stroke in patients with nonvalvular atrial... more

Predictors of cardiovascular events in patients with primary systemic vasculitis: A 5 years prospective observational study

30 May 2021
Author(s): Anna Borowiec, Ilona Kowalik, Tomasz Chwyczko, Jan Jankowski, Piotr Kandyba, Katarzyna Życińska

: Granulomatosis with polyangiitis (GPA) is one of antineutrophil cytoplasmic autoantibody (ANCA) – associated systemic vasculitis and is characterised by inflammation of blood vessels. Systemic... more

Epidemiology of sarcoidosis in northern Spain, 1999-2019: A population-based study

26 May 2021
Author(s): Raúl Fernández-Ramón, Jorge J. Gaitán-Valdizán, Lara Sánchez-Bilbao, José L. Martín-Varillas, David Martínez-López, Rosalía Demetrio-Pablo, M. Carmen González-Vela, José Cifrián, Santos Castañeda, Javier Llorca, Miguel A. González-Gay, Ricardo Blanco

Sarcoidosis is a multisystem disease of unknown etiology characterized by the formation of non-caseating granulomas [1]. Sarcoidosis primarily affects the lungs and lymphatic system, but any organ... more

Both lean and fat body mass associate with blood pressure

13 May 2021
Author(s): Päivi E. Korhonen, Tuija Mikkola, Hannu Kautiainen, Johan G. Eriksson

The positive relationship of body mass index (BMI) with blood pressure (BP) has been demonstrated in several large-scale observational studies [1–8]. Importantly, a causal association between BMI and... more

Very low lipoprotein(a) and increased mortality risk after myocardial infarction

7 May 2021
Author(s): Peter Wohlfahrt, Dominik Jenča, Vojtěch Melenovský, Janka Franeková, Antonín Jabor, Marek Šramko, Vladimír Staněk, Michael Želízko, Rudolf Poledne, Jan Piťha, Věra Adámková, Josef Kautzner

Lipoprotein(a) (Lp[a]) consists of a lipoprotein moiety identical to low density lipoprotein (LDL) cholesterol, as well as a plasminogen-similar glycoprotein apo(a). About 90% of a person's Lp(a)... more

The 3Ds – Discussion, diagnosis and direction: Elements for effective obesity care by healthcare professionals

23 January 2021
Author(s): Assim A. Alfadda, Ian D. Caterson, Walmir Coutinho, Ada Cuevas, Dror Dicker, Jason C.G. Halford, Carly A. Hughes, Masato Iwabu, Jae-Heon Kang, Rita Nawar, Ricardo Reynoso, Nicolai Rhee, Georgia Rigas, Javier Salvador, Verónica Vázquez-Velázquez, Paolo Sbraccia

Obesity is a chronic disease associated with multiple health complications [1]. Furthermore, the COVID-19 pandemic has made evident the impact obesity can have on health outcomes, whereby people with... more


How body composition may influence 24 hours blood pressure

2 August 2021
Author(s): Maria Lorenza Muiesan, Claudia Agabiti Rosei

In the last 10 years a global increase in risk exposure for attributable death has been observed for several factors, including ambient particulate matter pollution, drug use, high fasting plasma... more

Unexpected high mortality associated with very low lipoprotein(a) after acute myocardial infarction: Identifying the unknown

2 August 2021
Author(s): Felicita Andreotti, Massimo Massetti, Aldo P Maggioni

Plasma or serum concentrations of lipoprotein(a) - Lp(a) - are an established marker of risk for atherothrombotic cardiovascular disease (CVD) and for degenerative aortic valve stenosis (1).... more

Closing obesity care gaps and achieving health equity for people living with obesity

2 July 2021
Author(s): Ximena Ramos Salas

Lack of access to obesity care is contributing to health inequalities for people living with obesity [1,2]. Public health systems have not established obesity care paths and there is insufficient... more

Anti Ro52 antibodies: One step further, but still not there yet

30 June 2021
Author(s): Roberto Ríos-Garcés, Ricard Cervera

The term extractable nuclear antigens (ENAs) is a historical denomination, though still in use, derived from the observation that several antigens from the cell nuclei are soluble and can be isolated... more


Corrigendum to: Associations of proton pump inhibitors and hospitalization due to hyponatremia: A population–based case–control study. Eur J Intern Med. 2019 Jan;59:65-69

23 June 2021
Author(s): Henrik Falhammar, Jonatan D. Lindh, Jan Calissendorff, Jakob Skov, David Nathanson, Buster Mannheimer

The authors regret that in preparation of a new article based on the same data as in the previous published article [1], we unfortunately discovered two errors in the dataset. Some cases of... more

Internal Medicine Flashcard

Itchy papular and nodular skin lesions in chronic kidney disease patient

6 July 2021
Author(s): Isabel Borges, Patrícia Aranha

A 65-year-old man with a history of obesity, type 2 diabetes mellitus (DMT2) for more than 10 years, stage 3b chronic kidney disease (CKD) and hypertension was admitted to our internal medicine ward... more

Letter to the Editor

Comment to: Non-specific clinical presentations are not prognostic and do not anticipate hospital length of stay or resource utilization: Author's reply

20 July 2021
Author(s): Richard Conway, Bernard Silke

We thank Bingisser and colleagues for their interest in our article “Non-specific clinical presentations are not prognostic and do not anticipate hospital length of stay or resource utilization” [1,2...

The possibility of heart failure in patients with “Pneumonia” -Author's reply

18 July 2021
Author(s): Svenja Ravioli, Rebecca Gygli, Gregor Lindner

H. Ito provided a letter to the editor discussing our recently published study on electrolyte disorders in patients presenting to the emergency department with community-acquired pneumonia (CAP) [1... more

Primary adrenal insufficiency associated with Oxford-AstraZeneca ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia (VITT)

10 July 2021
Author(s): Jose F. Varona, Millán García-Isidro, Mojdeh Moeinvaziri, María Ramos-López, Manuel Fernández-Domínguez

Dear editor,

The link between nutritional status and outcomes in COVID-19 patients in ICU: Is obesity or sarcopenia the real problem?

7 July 2021
Author(s): Alessio Molfino, Giovanni Imbimbo, Veronica Rizzo, Maurizio Muscaritoli, Daniela Alampi

Obesity is frequent among COVID-19 patients and data indicate that this condition is associated with poor outcomes [1]. Nutritional status, in particular in COVID-19 patients in intensive care unit (... more

Wearing a mask does indeed matter: Lessons from the 2021 influenza infection season

1 July 2021
Author(s): Keigo Kobayashi, Masayuki Noguchi

Until recently, wearing masks, a long-term custom in Japan during the winter flu season and during early springtime to protect against Japanese cedar pollinosis was not common in everyday life in... more

Vaccine-induced thrombotic thrombocytopenia, a rare but severe case of friendly fire in the battle against COVID-19 pandemic: What pathogenesis?

28 June 2021
Author(s): Raimondo De Cristofaro, Maurizio Sanguinetti

We have read with great interest two recent contributions to the Clinical Insights section of the Journal concerning reports of thromboembolic complications associated with the administration of the... more

Risk factors of recurrence in patients with cancer-associated venous thromboembolism

7 June 2021
Author(s): Yuji Nishimoto, Yugo Yamashita, Takeshi Morimoto, Yukihito Sato, Takeshi Kimura, COMMAND VTE Registry Investigators

The following other authors from the COMMAND VTE Registry Investigators participated the study: Syunsuke Saga, MDa; Kazushige Kadota, MDb; Toru Takase, MDc; Seiichi Hiramori, MDd; Kitae Kim, MDe;... more

Dynamics of high-sensitivity troponin T and myocardial dysfunction during the first 72 h of septic shock

5 June 2021
Author(s): Cristina Murcia-Gubianas, Juan Carlos Yébenes, Maria Buxó, Josep-Maria Sirvent, Elisabeth Pinart

Cardiomyopathy is frequently associated with septic shock, despite divergences in type and severity of cardiac alterations making difficult the management of these patients. Different studies have... more

Diagnosis of hepatitis C-related liver disease in patients with mild hemophilia

5 June 2021
Author(s): Evelien Krumb, Catherine Lambert, Yves Horsmans, Cedric Hermans

Following the contamination of blood products with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) in the 1970s to 1980s, almost all hemophilia patients who received plasma-derived... more

Original Article

Laryngotracheal aspiration test reduce the false negative rate in patients with suspected SARS-COV-2 pneumonia despite a negative nasopharyngeal swab

23 June 2021
Author(s): Peiman Nazerian, Roberto M. Sacco, Monica Solbiati, Elena Targetti, Chiara Marta, Francesco Blasi, Giovanni Casazza, Maria Grazia Colao, Sara Tomassetti, Stefano Grifoni, Gian Maria Rossolini, Giorgio Costantino

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is undermining the ability of many emergency departments (EDs) to accurately diagnose and isolate novel coronavirus disease (... more

Incident atrial fibrillation and its risk prediction in patients developing COVID-19: A machine learning based algorithm approach

13 May 2021
Author(s): Gregory Y.H. Lip, Ash Genaidy, George Tran, Patricia Marroquin, Cara Estes

Multi-morbidity is associated with adverse health outcomes and healthcare costs, especially among the elderly [1,2]. Preliminary evidence suggests that multi-morbidity is associated with confirmed... more

Clinical significance of anti-Ro52 (TRIM21) antibodies in adult patients with connective tissue diseases

7 May 2021
Author(s): Paul Decker, Thomas Moulinet, Benjamin Lopez, Sylvain Dubucquoi, Bernard Bonnotte, Daniela Lakomy, Sabine Revuz, Amandine Luc, Marcelo De Carvalho Bittencourt, Eric Hachulla, Roland Jaussaud

Connective tissue diseases (CTD) – rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren syndrome (SS), systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), mixed... more

Patient motivation to lose weight: Importance of healthcare professional support, goals and self-efficacy

5 February 2021
Author(s): Dror Dicker, Assim A. Alfadda, Walmir Coutinho, Ada Cuevas, Jason C.G. Halford, Carly A. Hughes, Masato Iwabu, Jae-Heon Kang, Rita Nawar, Ricardo Reynoso, Nicolai Rhee, Georgia Rigas, Javier Salvador, Paolo Sbraccia, Verónica Vázquez-Velázquez, Ian D. Caterson

Obesity is a global health concern [1]. Multiple complications are associated with overweight and obesity including diabetes, heart disease, musculoskeletal disorders and some cancers, and people... more

Review Article

Obesity as an adipose tissue dysfunction disease and a risk factor for infections – Covid-19 as a case study

2 April 2021
Author(s): MF Landecho, M Marin-Oto, B Recalde-Zamacona, I Bilbao, Gema Frühbeck

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically... more


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