September 2023

32 Articles

No Section

Safety of SARS-CoV-2 mRNA vaccines and effects of immunosuppressive drugs on adverse reactions in patients with rheumatic diseases

16 June 2023
Author(s): Mai Kawazoe, Junko Nishio, Wataru Hirose, Karin Furukawa, Toshihiro Nanki

Patients with rheumatic diseases (RD) have a higher rate of poor outcomes of coronavirus disease 2019 (COVID-19) [1]. The American College of Rheumatology (ACR) and the European League Against... more

Clinical Insights

One year later: Prevalence of long-COVID symptoms

4 July 2023
Author(s): César Fernández-de-las-Peñas

It has been two years since the publication of one of the first meta-analyses investigating the prevalence of post-COVID symptomatology but differentiating between hospitalized and non-hospitalized... more

The spectrum of hospitalization-associated harm in the elderly

28 June 2023
Author(s): Ami Schattner

Hospital admission constitutes the standard of care for significant acute illness and have shown a marked and consistent worldwide increase over the last years. Nevertheless, not all admissions are... more

COVID-19 and smoking: Considerations after two years

24 May 2023
Author(s): Giuseppe Lippi, Brandon Michael Henry, Fabian Sanchis-Gomar

Although both virulence and pathogenicity of SARS-CoV-2 have considerably declined over time, the number of coronavirus disease 2019 (COVID-19) cases and the consequent clinical burden remain... more


Atherosclerosis in autoimmune rheumatic diseases

31 July 2023
Author(s): Zoltán Szekanecz, György Kerekes, Yehuda Shoenfeld

Autoimmune rheumatic and musculoskeletal diseases (RMDs) including rheumatoid arthritis (RA) and systemic sclerosis (SSc) and others have been associated with increased cardiovascular (CV) risk,... more

Modern technology meets established health care. Challenges and opportunities in fulfilling the promises of remote device monitoring in heart failure

25 July 2023
Author(s): Frieder Braunschweig

In 1961, American astronaut Alan Shepard became the second human being travelling into space. Onboard the spacecraft, some of his vital parameters, heart rate and rhythm, body temperature and... more

Unwarranted clinical practice variation and resource overutilization in medical care: The example of transfusion practices in elderly hospital patients

21 July 2023
Author(s): António Vaz Carneiro

Clinical practice variation refers to the differences in healthcare practices and treatment decisions among healthcare providers, for patients with similar clinical conditions [1]. These variations... more

The arduous challenge of seeking for biomarkers in rare diseases

14 July 2023
Author(s): Patrizia Suppressa, Luigi Rizzi

Hereditary haemorrhagic telangiectasia (HHT) is a rare genetic vascular disease that can significantly impair the quality of life of affected patients [1]. Medical management is mainly aimed at... more

Internal Medicine Flashcard

Unusual cause of acute severe epigastric pain in a Japanese woman

28 June 2023
Author(s): Hiroki Matsuura, Rio Fujita

A 42-year-old woman with 2-day history of acute onset severe epigastric pain, nausea, and vomiting presented to our emergency department. She had no previous significant cardiovascular or... more

A man with bright-golden orange phlegm

10 May 2023
Author(s): Jun Hirai, Nobuaki Mori, Hiroshige Mikamo

A 57-year-old Japanese man with a history of hypertension was admitted to our hospital complaining of headache and fatigue that started 3 days before. On admission, his consciousness was clear. He... more

Bad luck comes in threes

9 May 2023
Author(s): D Vandermeersch, P-Y Sansen, L Pothen

An 84-year-old Caucasian woman presented to our clinic with a diffuse erythematous skin eruption associated with fever and fatigue. The patient has a two-month-old diagnosis of cortico-resistant... more

Letter to the Editor

The efficacy and safety of out-hospital anticoagulation therapy with direct oral anticoagulant for COVID-19

28 June 2023
Author(s): Yu Geng, Chang Meng, Tong Gao, Ping Zhang, Yintang Wang

As coronavirus disease 2019 (COVID-19) has caused unprecedented morbidity and mortality in the global pandemic, effective strategies to treat and prevent the disease are urgently needed.... more

Clinically significant contrast-associated acute kidney injury after emergent computed tomography angiography of the cerebral arteries

12 June 2023
Author(s): Mariana Barosa, Tiago Barroso, Ricardo Marques, Joana Caetano, José Delgado Alves

Contrast associated acute kidney injury (CA-AKI) is defined as a sudden deterioration in renal function within 48 h following the intravascular administration of iodinated contrast medium[1]. CA-AKI... more

Association between diagnostic outcomes and symptom pattern in fever and inflammation of unknown origin

7 June 2023
Author(s): A. Betrains, L. Moreel, W.F. Wright, D. Blockmans, S. Vanderschueren

Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are syndromes that share a similar spectrum of causes and that are separated by an arbitrary temperature threshold [1]. They... more

A higher BMI is positively associated with advanced neck lymphoma at diagnosis

3 June 2023
Author(s): Mahmud Darawshe, Luiza Akria, Netanel A. Horowitz, Ohad Ronen

Lymphomas comprise a heterogeneous group of malignancies which can arise in different nodal and extranodal sites in the head and neck in which cervical lymphadenopathy is the most common head and... more

Comprehensive diagnostic evaluation of palpatory method of blood pressure measurement

31 May 2023
Author(s): Yogita Kumar, Pawan Kumar Singh, Dhruva Chaudhry, Amit Sharma, Pooja Yadav

Dear Editor,

Frailty in nursing home residents

29 May 2023
Author(s): Mario Rizzo, Antonella Pansini, Marisanta Colucci, Eugenio Boccalone, Pasquale Mone

Dear Editor,

Impact of the COVID-19 pandemic on the occurrence and outcome of cardiogenic shock complicating acute myocardial infarction

28 May 2023
Author(s): Zuzana Motovska, Ota Hlinomaz, Jan Mrozek, Petr Kala, Jiri Jarkovsky

SARS-CoV-2 predisposes patients to thrombotic disease due to excessive inflammation, platelet activation, endothelial dysfunction, and stasis [1]. The infection was recognized as an independent risk... more

Characteristics and outcomes of COVID-19-associated pulmonary embolism

25 May 2023
Author(s): Ramy Sedhom, Amr Mohsen, Liset Stoletniy, Dmitry Abramov, Islam Y. Elgendy

Pulmonary embolism (PE) in the setting of COVID-19 is related to the procoagulant state as evidenced by the increased d-dimer levels and in situ thrombosis [1,2] and it usually involves the segmental... more

Original Article

How does current disease activity in rheumatoid arthritis affect the short-term risk of acute coronary syndrome? A clinical register based study from Sweden and Norway

22 June 2023
Author(s): Bénédicte Delcoigne, Sella A. Provan, Eirik K Kristianslund, Johan Askling, Lotta Ljung

Cardiovascular (CV) disease (CVD) co-morbidity and mortality is one of the largest drivers of the excess morbidity and pre-term mortality in patients with rheumatoid arthritis (RA) [1–3]. The... more

Phenotypic Profiles Among 72 Caucasian and Afro-Caribbean Patients with Antisynthetase Syndrome Involving Anti-PL7 or Anti-PL12 Autoantibodies

15 June 2023
Author(s): Aurore Abel, Estibaliz Lazaro, Mamy Ralazamahaleo, Emma Pierrisnard, Benoit Suzon, Fabrice Bonnet, Patrick Mercié, Julie Macey, Moustapha Agossou, Jean-Francois Viallard, Christophe Deligny, Etienne Rivière

Antisynthetase syndrome (ASyS), a rare and heterogeneous systemic autoimmune disease, is classified as a subtype of idiopathic inflammatory myopathy (IIM). It is associated with at least one of the... more

Efficacy and safety assessment of mineralocorticoid receptor antagonists in patients with chronic kidney disease

14 June 2023
Author(s): Kaiyue Ding, Zhuoyu Li, Yingying Lu, Lin Sun

As a global health concern, chronic kidney disease (CKD) is threatening the health of 843.6 million people worldwide and is expected to become the 5th leading cause of death in 2040 [1,2]. CKD is... more

Subclinical coronary atherosclerosis, detected by computer tomography with coronary calcium score, and the occurrence of major cardiovascular events at 5 years of follow-up in a cohort of patients with systemic sclerosis

13 June 2023
Author(s): C Rotondo, S Sciacca, V Rella, G Busto, R Colia, FP Cantatore, A Corrado

Systemic sclerosis (SSc) is a rare disease, with a not well known pathogenesis based on autoimmune dysregulation, charcaterized by clinical triad of vasculopathy, fibrosis of diverse organs, and... more

Early glomerular filtration rates changes and risk of mortality in acute heart failure. The modifying role of admission renal function and decongestion

13 June 2023
Author(s): Miguel Lorenzo, Gonzalo Núñez, Laura Fuertes-Kenneally, Rafael de la Espriella, Sandra Villar, Oscar Miró, Pere Llorens, Enrique Santas, Gema Miñana, Vicent Bodí, Juan Sanchis, Arturo Carratalá, Antoni Bayés-Genís, Julio Núñez

The pathophysiology of changes in estimated glomerular filtration rate (eGFR) in acute heart failure (AHF) is complex and multifactorial. We evaluated the associated mortality risk of early changes... more

Ventricular arrhythmias and cardiac arrest in atrial fibrillation patients with pacemakers and implantable cardioverter-defibrillators

6 June 2023
Author(s): Ameenathul M. Fawzy, Arnaud Bisson, Sid A. Bentounes, Alexandre Bodin, Julien Herbert, Gregory Y.H. Lip, Laurent Fauchier

Atrial fibrillation (AF) continues to be a growing epidemic due to its increasing incidence, prevalence, and detrimental consequences. In 2017, the Global Burden of Disease study revealed 37.57... more

Incidence, mortality, and risk factors of acute kidney injury after immune checkpoint inhibitors: Systematic review and meta-analysis of real-world evidence

30 May 2023
Author(s): Wenhui Xie, Shiyu Xiao, Xiaoyuan Li, Jing Huang, Guangtao Li, Zhuoli Zhang

Immune checkpoint inhibitors (ICI) constitute an important breakthrough in anticancer treatments, which has been rapidly and widely prescribed worldwide [1]. There are a variety of ICIs currently... more

Anemia management and transfusion strategy in internal medicine units: Less is more

22 May 2023
Author(s): Deborah Blanca, Giorgio Parrella, Dario Consonni, Stefania Villa, Giuliana Ceriani, Annalisa Cespiati, Giovanni Figini, Gabriele Ghigliazza, Diletta Maira, Giovanna Oberti, Natalia Scaramellini, Giuseppina Luisa Schinco, Francesco Tafuri, Nicola Montano, Maria Domenica Cappellini, Irene Motta

Anemia is a global public health problem affecting subjects of all ages and gender, with significant consequences for human health and an impact on social and economic aspects. The aging of the... more

Genetic and clinical features of familial mediterranean fever (FMF) in a homogeneous cohort of patients from South-Eastern Italy

13 May 2023
Author(s): Agostino Di Ciaula, Matteo Iacoviello, Leonilde Bonfrate, Mohamad Khalil, Harshitha Shanmugam, Giuseppe Lopalco, Rosanna Bagnulo, Antonella Garganese, Florenzo Iannone, Nicoletta Resta, Piero Portincasa, Alessandro Stella

Hereditary recurrent fevers represent a heterogenous group of disorders considered systemic auto inflammatory diseases, caused mostly by monogenic mutations. Familial Mediterranean Fever (FMF), in... more

Review Article

Future treatments in hypertension: Can we meet the unmet needs of patients?

16 June 2023
Author(s): Mehmet Kanbay, Sidar Copur, Cem Tanriover, Duygu Ucku, Luke Laffin

The prevalence of arterial hypertension, defined as a persistent systolic blood pressure ≥ 130 mm Hg and/or diastolic blood pressure ≥ 80 mm Hg according to American College of Cardiology (ACC) and... more

Potential angiogenic biomarkers in hereditary hemorrhagic telangiectasia and other vascular diseases

22 May 2023
Author(s): B. Villanueva, P. Cerdà, R. Torres-Iglesias, J.L. Rocamora, A. Figueras, F. Viñals, A. Riera-Mestre

Vascular diseases are the main cause of death in developed countries [1]. Despite much progress has been made to improve the management of these diseases, it is difficult to predict those patients at... more

Remote multiparametric monitoring and management of heart failure patients through cardiac implantable electronic devices

17 April 2023
Author(s): Giuseppe Boriani, Jacopo F. Imberti, Niccolò Bonini, Cosimo Carriere, Davide A. Mei, Massimo Zecchin, Francesca Piccinin, Marco Vitolo, Gianfranco Sinagra

Heart failure (HF) is currently an important driver of hospitalizations and re-hospitalizations. It is associated with a high risk of adverse cardiovascular outcomes including death, inducing also an... more


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