European Journal of Internal Medicine

June 2016

34 Articles

No Section

Unique medical issues in adult patients with mucopolysaccharidoses

10 June 2016
Author(s): John Mitchell, Kenneth I. Berger, Andrea Borgo, Elizabeth A. Braunlin, Barbara K. Burton, Kemel A. Ghotme, Susanne G. Kircher, David Molter, Paul J. Orchard, James Palmer, Gregory M. Pastores, David M. Rapoport, Raymond Y. Wang, Klane White

The mucopolysaccharidoses are a group of inherited metabolic diseases caused by deficiencies in enzymes involved in the sequential degradation of glycosaminoglycans (GAGs) leading to substrate... more

Ensuring the highest eradication rates in H. pylori: the case of non-bismuth quadruple concomitant therapy

11 June 2016
Author(s): Adrian G. McNicholl, Javier P. Gisbert

Management of Helicobacter pylori infection is still a problem in daily routine for many gastroenterologists, internists, and general practitioners [1,2]. These problems range from which patients... more

The increasing incidence of infective endocarditis in Denmark, 1994–2011

21 June 2016
Author(s): Purnima Erichsen, Gunnar H. Gislason, Niels Eske Bruun

Little updated population-based evidence exists of temporal trends in infective endocarditis (IE).

Letter to the Editor

Data sharing: When better may be the enemy of good

27 June 2016
Author(s): Sergio Harari

The prospect of international “data sharing” on randomized clinical trials, recently relaunched by the International Committee of Medical Journal Editors [1], is fascinating, but it is felt that some... more

Reporting of secondary data analysis using routinely collected health data

2 June 2016
Author(s): Malcolm Koo

Secondary analysis of existing data sets can be a cost-effective approach to conduct health research. In Taiwan, the availability of the claimed data from the single-payer, mandatory national health... more

Neuropsychological performance of young familial hypercholesterolemia patients

2 June 2016
Author(s): Mar Ariza, Natalia Cuenca, Marta Mauri, M. Angels Jurado, Maite Garolera

Familial hypercholesterolemia (FH) is the most common disorder of lipid metabolism and can be caused by defects in different genes that code for proteins involved in hepatic clearance of low-density... more

Frequency of abnormal T-cells in hypereosinophilic syndrome and hypereosinophilia of undetermined significance— Extended follow-up

4 June 2016
Author(s): Grzegorz Helbig, Joanna Dziaczkowska-Suszek, Tomasz Francuz, Karolina Torba, Sławomira Kyrcz-Krzemień

Hypereosinophilic syndrome (HES) is defined by 1) blood hypereosinophilia (HE), 2) HE-attributable organ damage/dysfunction and 3) the absence of other conditions or disorders which may be... more

Methods to develop a scoring system for disease severity classification: More than clinical experience and expertise

8 June 2016
Author(s): Mao Li, Caigang Xu

We read with great interest the article titled ‘Development of a new disease severity scoring system for patients with non-transfusion-dependent thalassemia’ by Cappellini et al. [1]. In their... more

Integrated care in the management of chronic diseases: an Italian perspective

22 June 2016
Author(s): Ilario Stefani, Francesca Scolari, Davide Croce, Antonino Mazzone

This letter provides a view on the issue of the organizational model of Primary Care Groups (PCGs), which represent a best practice in continuity and appropriateness of care for chronic patients. Our... more

High levels of serum homocysteine in non-alcoholic steatohepatitis

25 June 2016
Author(s): Nicoleta V. Leach, Eleonora Dronca, Elena C. Craciun, Dana Crisan

Considering the original paper and the Letter to the editor by Polyzos et al. [1] regarding our original paper, on the same topic, published in your journal, we decided to bring forth our point of... more

‘There will be blood’. Differences in the pictorial representation of the arterial spurt of blood in Caravaggio and followers

25 June 2016
Author(s): A. Perciaccante, P. Charlier, A. Coralli, R. Bianucci

The theme of the beheading of Holofernes by Judith is one of the most frequently painted biblical scenes [1]. Famous painters such as Mantegna (1431–1506), Michelangelo (1475–1564), Botticelli (1445–... more

The death of Alaric I (c. 370–410AD), the vanquisher of Rome: Additional arguments strengthening the possible involvement of malaria

27 June 2016
Author(s): Eric Faure

I read with great interest the recent publication written by Galassi et al. [1] concerning the possible cause of Alaric I's sudden death. Using a dual philological–medical approach, the authors... more

Letters to the Editor

Major gaps between recommended perioperative diabetes care and current practice

21 June 2016
Author(s): Inge Hommel, Petra J. van Gurp, Cees J. Tack, Reinier P. Akkermans, Hub Wollersheim, Marlies E.J.L. Hulscher

Surgery for patients with diabetes is associated with longer hospital stay, more use of healthcare resources and increased perioperative morbidity and mortality compared to patients without diabetes... more

Original Article

Prognostic impact of comorbidities in hospitalized patients with acute exacerbation of chronic heart failure

1 June 2016
Author(s): Domenico Scrutinio, Andrea Passantino, Pietro Guida, Enrico Ammirati, Fabrizio Oliva, Simona Sarzi Braga, Maria Teresa La Rovere, Rocco Lagioia, Maria Frigerio

To assess the impact of comorbidities on long-term all-cause mortality in patients hospitalized with exacerbated signs/symptoms of previously chronic stable HF (AE-CHF).

Biomarkers of kidney function and prediction of death from cardiovascular and other causes in the elderly: A 9-year follow-up study

28 June 2016
Author(s): Marika Salminen, Kaisa Laine, Päivi Korhonen, Elise Wasen, Tero Vahlberg, Raimo Isoaho, Sirkka-Liisa Kivelä, Minna Löppönen, Kerttu Irjala

Cystatin C is claimed to be superior to creatinine-based estimates of glomerular filtration rate (eGFRcr). The purpose of the study is to analyze whether cystatin C, creatinine, and/or estimated... more

Polypharmacy and specific comorbidities in university primary care settings

8 June 2016
Author(s): Carole E. Aubert, Sven Streit, Bruno Da Costa, Tinh-Hai Collet, Jacques Cornuz, Jean-Michel Gaspoz, Doug Bauer, Drahomir Aujesky, Nicolas Rodondi

Polypharmacy is associated with adverse events and multimorbidity, but data are limited on its association with specific comorbidities in primary care settings. We measured the prevalence of... more

Clinical management and outcome of major bleeding in patients on treatment with vitamin K antagonists

9 June 2016
Author(s): C. Becattini, L. Franco, L. Masotti, C. Nitti, S. Cattinelli, R. Cappelli, G. Manina, R. Sbrojavacca, F. Pomero, G. Agnelli

The optimal management of major bleeding associated with vitamin K antagonists remains unclear.

Electrocardiographic abnormalities and relative bradycardia in patients with hantavirus-induced nephropathia epidemica

10 June 2016
Author(s): Daniel Kitterer, Simon Greulich, Stefan Grün, Stephan Segerer, Jukka Mustonen, M. Dominik Alscher, Niko Braun, Joerg Latus

Nephropathia epidemica (NE), caused by Puumala virus (PUUV), is characterized by acute kidney injury (AKI) and thrombocytopenia. Cardiac involvement with electrocardiographic (ECG) abnormalities has... more

Bleeding in patients with atrial fibrillation treated with dabigatran, rivaroxaban or warfarin: A retrospective population-based cohort study

10 June 2016
Author(s): Martin H. Ellis, Tsipora Neuman, Haim Bitterman, Sari Greenberg Dotan, Ariel Hammerman, Erez Battat, John W. Eikelboom, Jeffrey S. Ginsberg, Jack Hirsh

Randomized controlled trials (RCTs) have shown that dabigatran, rivaroxaban and warfarin cause similar bleeding rates.

Diabetic striatopathy—Does it exist in non-Asian subjects?

11 June 2016
Author(s): Inbal Shafran, Gahl Greenberg, Ehud Grossman, Avshalom Leibowitz

Diabetic striatopathy (DS) is a rare complication of diabetes mellitus (DM). The syndrome appears in patients with uncontrolled DM and is characterized by abrupt onset of movement disorder, mainly... more

Influence of age on perioperative major adverse cardiovascular events and mortality risks in elective non-cardiac surgery

13 June 2016
Author(s): Peter Wæde Hansen, Gunnar H. Gislason, Mads Emil Jørgensen, Lars Køber, Per Føge Jensen, Christian Torp-Pedersen, Charlotte Andersson

Advanced age increases the risk of perioperative cardiovascular complications and may pose reluctance to subject elderly patients to surgery. We examined the impact of high age on perioperative major... more

Colon neoplasia in patients with type 2 diabetes on metformin: A meta-analysis

15 June 2016
Author(s): T. Rokkas, P. Portincasa

A growing body of evidence has suggested that metformin potentially reduces the risk of cancer.

Daytime sleepiness is associated with hyperhomocysteinemia in rural area of China: A cross-sectional study

16 June 2016
Author(s): Naijin Zhang, Shuang Chen, Yintao Chen, Xiaofan Guo, Guozhe Sun, Hao Qian, Yingxian Sun

To ascertain whether sleep abnormalities including daytime sleepiness, snoring, apnea, sleep disruption and sleep duration abnormity are significantly associated with hyperhomocysteinemia (Hhcy).

Choose your outcomes: From the mean to the personalized assessment of outcomes in COPD. An exploratory pragmatic survey

17 June 2016
Author(s): Fulvio Braido, Ilaria Baiardini, Giorgia Molinengo, Silvia Garuti, Marta Ferrari, Marco Mantero, Francesco Blasi, Giorgio Walter Canonica

Patient's expectations and needs may influence adherence in chronic obstructive pulmonary disease (COPD). The objectives of this survey were to assess the specific outcomes that patients expected... more

Double balloon enteroscopy: A 7Year experience at a tertiary care Centre

20 June 2016
Author(s): Selçuk Dişibeyaz, Nuretdin Suna, Ufuk Barış Kuzu, Fatih Saygılı, Erkin Öztaş, Bülent Ödemiş, İbrahim Koral Önal, Zeki Mesut Yalın Kılıç, Meral Akdoğan, Ertuğrul Kayaçetin

Double Balloon Enteroscopy (DBE) provides the opportunity not only to investigate but also apply endoscopic therapeutic interventions for small intestinal disturbances. The aim of this study is to... more

A single-centre cohort study of National Early Warning Score (NEWS) and near patient testing in acute medical admissions

23 June 2016
Author(s): Tom E.F. Abbott, Hew D.T. Torrance, Nicholas Cron, Nidhi Vaid, Julian Emmanuel

The utility of an early warning score may be improved when used with near patient testing. However, this has not yet been investigated for National Early Warning Score (NEWS). We hypothesised that... more

Obesity and hypomagnesemia

25 June 2016
Author(s): Fernando Guerrero-Romero, Araceli Flores-García, Stephanie Saldaña-Guerrero, Luis E. Simental-Mendía, Martha Rodríguez-Morán

Whether low serum magnesium is an epiphenomenon related with obesity or, whether obesity per se is cause of hypomagnesemia, remains to be clarified.

Prognostic role of survivin in renal cell carcinoma: A system review and meta-analysis

25 June 2016
Author(s): Chaohui Xiong, Haipeng Liu, Zexin Chen, Yunxian Yu, Chaozhao Liang

Survivin plays an important role in cancer pathogenesis, which has been suggested to be related to poor prognosis in renal cell carcinoma (RCC). We performed a meta-analysis to quantify the... more

Fifteen-year mortality of patients with asthma–COPD overlap syndrome

26 June 2016
Author(s): Claudio Sorino, Claudio Pedone, Nicola Scichilone

The coexistence of asthma and chronic obstructive pulmonary disease (asthma–COPD overlap syndrome: ACOS) is increasingly recognized but data about its prevalence and long-term mortality are needed.

Declining trends in the incidence of hip fractures in people aged 65years or over in years 2000–2011

27 June 2016
Author(s): Sandro Giannini, Stefania Sella, Maurizio Rossini, Daniela Braghin, Davide Gatti, Maria Teresa Vilei, Annalisa Amabile, Maria Fusaro, Anna Chiara Frigo, Giuseppe Sergi, Roberto Lovato, Martino Nobile, Fabrizio Fabris, Silvano Adami

The aim of this study was to explore hip fracture (HFx) incidence in the Veneto Region of Italy, looking at potential differences with the national data.

Reflections in Internal Medicine

Biological agents and biosimilars: Essential information for the internist

21 June 2016
Author(s): Luca Pasina, Gianluigi Casadei, Alessandro Nobili

Biologics embrace a wide range of substances synthesized by cells or living organisms by means of different biological processes, including recombinant DNA technology, controlled gene expression, or... more

Review Article

Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors to treat hypercholesterolemia: Effect on stroke risk

28 June 2016
Author(s): Haralampos Milionis, Fotios Barkas, George Ntaios, Vasileios Papavasileiou, Kostantinos Vemmos, Patrick Michel, Moses Elisaf

A reduction of cardiovascular events has been reported in phase 2 and 3 trials of the proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors alirocumab and evolocumab. We aimed to investigate... more

Aspirin, platelets, and cancer: The point of view of the internist

22 June 2016
Author(s): F. Santilli, A. Boccatonda, G. Davì

Growing evidence suggests the beneficial effect of aspirin against some types of cancer, particularly of the gastrointestinal tract, and it has been provided for an effect both in cancer prevention... more

How should hyperferritinaemia be investigated and managed?

23 June 2016
Author(s): Sim Y. Ong, Amanda J. Nicoll, Martin B. Delatycki

Hyperferritinaemia is commonly found in clinical practice. In assessing the cause of hyperferritinaemia, it is important to identify if there is true iron overload or not as hyperferritinaemia may be... more