Published: 17 June 2022
Author(s): Karel J. van Erpecum, Paul Didden, Robert C. Verdonk
Issue: August 2022
Section: Commentary

Acute pancreatitis is one of the most common gastrointestinal diseases requiring acute hospital admission. Gallstones (50%) and alcohol (20%) are the most frequent underlying causes. Medication, endoscopic retrograde cholangiopancreaticography (ERCP), hypercalciemia, hypertriglyceridaemia, autoimmune pancratitis, infection, genetic mutations and trauma are responsible for the remaining 30%. In most patients, the disease has a mild and self-limiting course, but in approximately 20% moderate or severe pancreatitis develops, with (peri)pancreatic necrosis, organ failure, formation of collections, infectious complications and a substantial mortality.


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