August 2022

27 Articles


Renin-angiotensin-aldosterone inhibition in chronic heart failure: From theory into practice

1 July 2022
Author(s): Raúl Ramos, Pedro Moliner, Josep Comin-Colet

Heart failure (HF) is an extremely relevant chronic disease impacting on quality of life and prognosis. Furthermore, the increasing prevalence of HF leads to a huge number of admissions and entails... more

High risk of complications and mortality in cirrhotic patients with acute pancreatitis

17 June 2022
Author(s): Karel J. van Erpecum, Paul Didden, Robert C. Verdonk

Acute pancreatitis is one of the most common gastrointestinal diseases requiring acute hospital admission. Gallstones (50%) and alcohol (20%) are the most frequent underlying causes. Medication,... more

Lights and shadows on JAK inhibitors for Ankylosing Spondylitis

20 May 2022
Author(s): Giovanni Benanti, Lorenzo Dagna, Corrado Campochiaro

Ankylosing Spondylitis (AS) is an autoimmune disease characterized by inflammation of the spine and sacroiliac joints, historically described in young males with progressive structural damage of the... more

Internal Medicine Flashcard

An unusual cause of severe watery diarrhea

16 May 2022
Author(s): Yusaku Kajihara

A 75-year-old man presented to the gastroenterology department with a 4-week history of severe watery diarrhea (at least 20 times a day) and appetite loss. He had been taking amlodipine 5 mg once... more

A HIV-positive subject with dermatomal and generalized vesicular skin lesions

13 May 2022
Author(s): Andrea Poloni, Maria Vittoria Cossu, Spinello Antinori

A 58-year old man with HIV infection diagnosed in 2018 presented in July 2021 with a 7-day history of vesicular skin lesions localized to the right side of abdomen and diffuse vesicular lesions on... more

Skin rash following amoxicillin treatment

13 May 2022
Author(s): Yuya Ando, Satoko Senda, Yosuke Ono

A 26-year-old woman presented with a chief complaint of nausea for 2 days. On the previous day, she had been diagnosed with tonsilitis by her previous doctor because of fever and sore throat, and had... more

Letter to the Editor

The Omicron wave and the waning of COVID-19 vaccine effectiveness. Influence of vaccine booster and age on confirmed infection incidence

26 May 2022
Author(s): Luis Corral-Gudino, María Piedad Del-Amo-Merino, José María Eiros-Bouza, Jesús Fernando García-Cruces-Méndez, Marta Domínguez-Gil González

Dear Editor,

Personal protective equipment portraits in the era of COVID-19

26 May 2022
Author(s): Christopher Hansen-Barkun, Omar Kherad, Adamo A Donovan, Anupa J Prashad, Maida J Sewitch

Use of personal protective equipment (PPE) aims to prevent SARS CoV-2 transmission in the healthcare setting. However, PPE limits human connection and non-verbal communication by masking individuals... more

Efficacy and safety of molnupiravir for COVID-19 patients

25 May 2022
Author(s): Maurish Fatima, Saleha Azeem, Junaid Saeed, Abia Shahid, Huzaifa Ahmad Cheema, COVID-19 Therapeutics Study Group

Dear Editor,

Disease phenotype and outcomes of very early-onset inflammatory bowel disease

6 May 2022
Author(s): Valeria Dipasquale, Giovanna Lo Presti, Claudio Romano

Dear Editor,

Risk factors for chronic thromboemboli after pulmonary thromboembolism

22 April 2022
Author(s): N Leal, A Freitas, F Leal, J Pimenta, T Gregório

Pulmonary thromboembolism is the third leading cause of cardiovascular death, after coronary artery disease and stroke [1].

General practitioner agreement and adherence to the Swiss Choosing wisely top 5 list: A cross-sectional survey

21 April 2022
Author(s): Mae Cuérel, Marc-André Raetzo, Kevin Selby, Omar Kherad

Choosing Wisely (CW) campaigns have spread around the world to stimulate conversations between physicians and patients about unnecessary tests, treatments, and procedures that account for up to 20%... more

Serum-ascites albumin gradient – A false dichotomy in the approach to ascites

15 April 2022
Author(s): Isaac Núñez, Fernando Solis-Huerta, Adrian Soto-Mota

Ascites is a clinical scenario frequently encountered in primary care, internal medicine and gastroenterology. Formal guidelines on its approach and management exist and recommend measuring the serum... more

Experience with procalcitonin use during the COVID-19 pandemic

13 April 2022
Author(s): Laura Gonzalez, Thomas Holman, Daniel Wait, Pearl Abenojar

Procalcitonin (PCT) is a protein precursor of calcitonin that has been proposed to differentiate systemic inflammation of bacterial origin from viral. The lack of rise in viral infections may be due... more

Hospitalized patients are needlessly over-tested for heparin induced thrombocytopenia

11 April 2022
Author(s): Udhayvir Singh Grewal, Shiva Jashwanth Gaddam, Sahith Reddy Thotamgari, Tyiesha Brown, Kavitha Beedupalli, Glenn Morris Mills

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Patients with HIT present with a decline... more

Original Article

External validation of risk scores to predict in-hospital mortality in patients hospitalized due to coronavirus disease 2019

7 June 2022
Author(s): Shermarke Hassan, Chava L. Ramspek, Barbara Ferrari, Merel van Diepen, Raffaella Rossio, Rachel Knevel, Vincenzo la Mura, Andrea Artoni, Ida Martinelli, Alessandra Bandera, Alessandro Nobili, Andrea Gori, Francesco Blasi, Ciro Canetta, Nicola Montano, Frits R. Rosendaal, Flora Peyvandi, LUMC‐COVID‐19 Research Group, COVID-19 Network working group

The coronavirus disease 2019 (COVID-19) epidemic, which started in early December 2019, presents an important threat to global health. As of October 18th 2021, the number of patients confirmed to... more

High risk of complications and acute-on-chronic liver failure in cirrhosis patients with acute pancreatitis

4 June 2022
Author(s): Michael Vogel, Hanno Ehlken, Stefan Kluge, Thomas Roesch, Ansgar W. Lohse, Samuel Huber, Martina Sterneck, Peter Huebener

Lay summary: Acute pancreatitis (AP) and advanced chronic liver disease are severe and increasingly prevalent disorders with overlapping risk factors. We demonstrate for the first time that the... more

T-cell immune response predicts the risk of critical SARS-Cov2 infection in hospitalized COVID-19 patients

2 June 2022
Author(s): Maxime Samson, Barbara Nicolas, Marion Ciudad, Hélène Greigert, Alexandre Guilhem, Claudie Cladiere, Cécile Straub, Mathieu Blot, Lionel Piroth, Thomas Rogier, Hervé Devilliers, Patrick Manckoundia, Thibault Ghesquiere, Stéphanie Francois, Daniela Lakomy, Sylvain Audia, Bernard Bonnotte

Assessment of Th17 cells could help target patients in need of anti-IL6R therapy.

Diagnostic approaches to syncope in Internal Medicine Departments and their effect on mortality

20 May 2022
Author(s): Ehud Galron, Orli Kehat, Ahuva Weiss-Meilik, Raffaello Furlan, Giris Jacob

Syncope is defined as a transient loss of consciousness (TLOC) due to cerebral hypoperfusion, characterized by a rapid onset, short duration, and spontaneous complete recovery [1]. The main... more

Impact of cardiac amyloidosis on outcomes of patients hospitalized with heart failure

16 May 2022
Author(s): Sebastian Göbel, Lukas Hobohm, Alexander Desuki, Tommaso Gori, Thomas Münzel, Rapezzi Claudio, Philip Wenzel, Karsten Keller

Amyloidosis is a multi-systemic disease resulting from deposition of misfolded proteins as insoluble fibrils in the interstitium of affected organs, subsequently leading to organ failure. Cardiac... more

Developing a simple and practical decision model to predict the risk of incident type 2 diabetes among the general population: The Study

12 May 2022
Author(s): Sergio Martínez-Hervás, María M. Morales-Suarez-Varela, Irene Andrés-Blasco, Francisco Lara-Hernández, Isabel Peraita-Costa, José T. Real, Ana-Bárbara García-García, F. Javier Chaves

The prevalence and incidence of type 2 diabetes mellitus (T2DM) are increasing worldwide, and an estimated 50% of patients remain unaware of their disease [1]. T2DM is a highly prevalent chronic... more

Atrial cardiomyopathy markers and new-onset atrial fibrillation risk in patients with acute myocardial infarction

2 May 2022
Author(s): Zhitong Li, Quanbo Liu, Fei Liu, Tesfaldet H. Hidru, Yiheng Yang, Shihao Wang, Lan Bai, Jing Chen, Xiaolei Yang, Yunlong Xia

Acute myocardial infarction (AMI) remains one of the leading causes of mortality globally, new-onset AF (NOAF) after AMI is a common complication of AMI, with an incidence of 6% to 21% [1], which is... more

Efficacy and safety of Janus kinase inhibitors in patients with ankylosing spondylitis: A systematic review and meta-analysis

20 April 2022
Author(s): Shu Li, Fen Li, Ni Mao, Jia Wang, Xi Xie

Ankylosing spondylitis (AS), also known as radiographic axial spondyloarthritis, is the advanced disease stage of axial spondyloarthritis (axSpA) [1]. It was characterized by enthesitis involving the... more

Review Article

Treatment strategies of COVID-19: A rheumatology perspective

11 May 2022
Author(s): Alexandros A. Drosos, Eleftherios Pelechas, Paraskevi V. Voulgari

Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China at the end of 2019 and has developed into a pandemic. The disease has... more

Low serum albumin: A neglected predictor in patients with cardiovascular disease

7 May 2022
Author(s): Antonis A. Manolis, Theodora A. Manolis, Helen Melita, Dimitri P. Mikhailidis, Antonis S. Manolis

Albumin, the most abundant circulating protein in blood (accounting for 50% of the plasma proteins), composed of 585 amino acids with a molecular weight of 66 kDa, binds and transports various drugs... more

Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond

6 May 2022
Author(s): Cristina Morelli, Gessica Ingrasciotta, Daniel Jacoby, Ahmad Masri, Iacopo Olivotto

In recent years, constant progress in science and technology has resulted in innovative molecules addressing core mechanisms of myocardial disease affecting millions worldwide [1]. A targeted... more

Renin-angiotensin-aldosterone system inhibition in patients affected by heart failure: efficacy, mechanistic effects and practical use of sacubitril/valsartan. Position Paper of the Italian Society of Cardiology

22 April 2022
Author(s): Pasquale Perrone-Filardi, Stefania Paolillo, Piergiuseppe Agostoni, Christian Basile, Cristina Basso, Francesco Barillà, Michele Correale, Antonio Curcio, Massimo Mancone, Marco Merlo, Marco Metra, Saverio Muscoli, Savina Nodari, Alberto Palazzuoli, Roberto Pedrinelli, Roberto Pontremoli, Michele Senni, Massimo Volpe, Ciro Indolfi, Gianfranco Sinagra

Renin-angiotensin-aldosterone system (RAAS) activation is one the main pathophysiological mechanisms involved in the development and progression of heart failure (HF) and its inhibition is a mainstay... more


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