Published: 19 October 2020
Author(s): Tatiana Kuznetsova, Nicholas Cauwenberghs
Section: Letter to the Editor

Similar to SARS-CoV, the novel coronavirus (SARS-CoV-2) uses the angiotensin-converting enzyme 2 (ACE2) receptor to infiltrate target cells [1]. Previous experimental study provided the genetic proof that ACE2 is indeed a crucial for effective replication of infectious SARS-CoV [2]. Indeed, pathologic alterations in lungs of infected mice were reduced in ACE2 knockout mice compared to wild-type mice. It was suggested that higher ACE2 protein expression might be associated with a higher local viral load [2].


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