February 2021

26 Articles

No Section

Cardiac imaging in heart failure in the personalized medicine era: Pathway to knowledge or Tiresias’ paradox?

8 January 2021
Author(s): Gherardo Finocchiaro, Gerald Carr-White, Gianfranco Sinagra

Tiresias was the blind prophet of Apollo in Thebes. His figure finds roots in Greek mythology and recurs in literature and art. In Sophocles' Oedipus Rex, Tiresias discloses an appalling truth to... more


Sex, age and venous thrombosis—Are men and women indeed from different planets?

5 January 2021
Author(s): Sabine Eichinger, Paul A. Kyrle

“Mars or Venus” titled Elliot and Rubin their editorial that accompanied the landmark study which described for the first time the strikingly higher risk of recurrent venous thromboembolism (VTE) in... more

COPD is not only one of the several VTE risk factors

24 December 2020
Author(s): Laurent BERTOLETTI, Francis COUTURAUD

Chronic obstructive pulmonary disease (COPD) is a frequent and severe chronic respiratory disease [1]. It is ranked in the 5th main causes of death worldwide [1]. Patients with COPD suffer from... more

Internal Medicine Flashcard

Family rash

24 November 2020
Author(s): Fabrizio Elia, Moreno Dutto, Valeria Milazzo

A healty 35-year-old woman suddenly developed a papular rash with linear disposition, involving predominantly her arms. She had no history of allergies and did not take any medication; moreover she... more

Concomitant pulmonary and rib lesions in a 44-year-old male nonsmoker

23 November 2020
Author(s): De-an Qin, Jie Jiang, Yun-peng Wang

A 44-year-old male nonsmoker presented to the respiratory department with progressive left chest pain for 20 days. He had previously been healthy with normal immunity. He had no cough, fever,... more

“High absorption area in the pelvis”

23 November 2020
Author(s): Jin Ikeda

A 42-year-old man presented to our emergency room with epigastric pain. He had undergone a barium examination 6 weeks previously for gastric cancer screening. He was apyrexial. Physical examination... more

Letter to the Editor

From the CHA2DS2-VASc score to inflammation: a path leading to frailty? An update of the PURE-Rhythm Trial

16 December 2020
Author(s): Stefano Fumagalli, Claudia Di Serio, Giulia Ricciardi, Gregory Y.H. Lip, Niccolò Marchionni, for the PURE-Rhythm Trial Investigators

Atrial fibrillation (AF) is the most frequently sustained arrhythmia diagnosed in elderly patients. AF is associated with an increased thrombo-embolic risk and with the development of heart failure... more

Comparative analysis of adropin concentration changes in response to kidney transplantation

16 December 2020
Author(s): Elżbieta Cecerska-Heryć, Daria Adamiak, Natalia Serwin, Bartłomiej Grygorcewicz, Barbara Dołęgowska

Adropin acts as an energy regulator through lipid and glucose metabolism [1,2]. This 76 amino acid protein encoded by the ENHO (Energy Homeostasis Associated Gene) gene is primarily expressed in the... more

Prevalence and influence of gastroesophageal reflux symptoms on sleep apnea and sleepiness

3 December 2020
Author(s): Dejan Radovanovic, Stefano Pini, Maurizio Rizzi, Elisa Franceschi, Pierachille Santus

To the Editor,

Home-based COVID 19 management: A consensus document from Italian general medical practitioners and hospital consultants in the Lombardy region (Italy)

2 December 2020
Author(s): Nuccia Morici, Massimo Puoti, Maria Teresa Zocchi, Carla Brambilla, Andrea Mangiagalli, Stefano Savonitto

The coronavirus disease 2019 (COVID-19) pandemic has infected more than 56,628,581 people causing 1,406,449 deaths worldwide, as of November 24, 2020. [1] Among the 17,131,853 active cases (November... more

Prescription of interleukin-1 inhibitors in a French adult cohort of familial Mediterranean fever

19 November 2020
Author(s): Antoine Fayand, Léa Savey, Stéphanie Ducharme-Bénard, Gilles Grateau, Sophie Georgin-Lavialle

Dear Editor,

What changed in the Italian internal medicine and geriatric wards during the lockdown

7 November 2020
Author(s): Barbara D'Avanzo, Alessandro Nobili, Mauro Tettamanti, Luca Pasina, Pier Mannuccio Mannucci, the REPOSI Study Group

Italy was the most affected European country in the first few weeks of the COVID-19 pandemic, with a dramatic burden on sub-intensive and intensive care units. Among the several arrangements... more

Autoimmune disorders and venous thromboembolism: An update from the COMMAND VTE registry

24 October 2020
Author(s): Yugo Yamashita, Takeshi Morimoto, Kazushige Kadota, Koh Ono, Takeshi Kimura

There are various well-known predisposing risk factors for development of venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), and several studies reported... more

Determinants of circulating angiotensin-converting enzyme 2 protein levels in the general population

19 October 2020
Author(s): Tatiana Kuznetsova, Nicholas Cauwenberghs

Similar to SARS-CoV, the novel coronavirus (SARS-CoV-2) uses the angiotensin-converting enzyme 2 (ACE2) receptor to infiltrate target cells [1]. Previous experimental study provided the genetic proof... more

Risk of thrombosis, pregnancy morbidity or death in antiphospholipid antibodies positive patients with or without thrombocytopenia

17 October 2020
Author(s): Thomas Moulinet, Virginie Dufrost, Isabelle Clerc-Urmès, Denis Wahl, Stéphane Zuily

Antiphospholipid syndrome (APS) is an immune-mediated acquired disorder characterized by venous, arterial or small vessels thromboses and/or obstetrical morbidity, and the persistent presence of... more

Original Article

Efficacy and safety of rituximab biosimilar (CT-P10) in IgG4-related disease: an observational prospective open-label cohort study

29 December 2020
Author(s): Emanuel Della-Torre, Marco Lanzillotta, Corrado Campochiaro, Giulia Di-Colo, Gaia Mancuso, Gabriele Capurso, Massimo Falconi, Lorenzo Dagna

IgG4-related disease (IgG4-RD) is an increasingly recognized immune-mediated disorder that can affect almost every organ system and cause severe damage if left untreated [1-5]. Clinical and... more

Negligible HCC risk during stringently defined untreated immune-tolerant phase of chronic hepatitis B

4 December 2020
Author(s): Hye Won Lee, Young Eun Chon, Beom Kyung Kim, Terry Cheuk-Fung Yip, Yee-Kit Tse, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Henry Lik-Yuen Chan, Sang Hoon Ahn

Among patients with chronic hepatitis B (CHB), a persistently high serum hepatitis B virus (HBV)-DNA level, a surrogate marker of active HBV replication in hepatocytes, is associated with an... more

The effect of COPD on the incidence and mortality of hospitalized patients with pulmonary embolism: A nationwide population-based study (2016-2018)

26 November 2020
Author(s): Javier de-Miguel-Diez, Romana Albaladejo-Vicente, Rodrigo Jiménez-García, Valentín Hernandez-Barrera, Rosa Villanueva-Orbaiz, David Carabantes-Alarcon, David Jimenez, Manuel Monreal, Ana López-de-Andrés

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in the world. It affects more than 10% of people over 40 years old and is expected to become the third leading... more

Long-term recurrence risk after a first venous thromboembolism in men and women under 50 years old: A French prospective cohort

16 November 2020
Author(s): Claire de Moreuil, Raphael Le Mao, Emmanuelle Le Moigne, Brigitte Pan-Petesch, Cécile Tromeur, Clément Hoffmann, Pierre-Yves Salaun, Michel Nonent, Marc Danguy des Déserts, Xavier Savary, Marie Guegan, Elise Poulhazan, Christophe Leroyer, Karine Lacut, Francis Couturaud

Venous thromboembolism (VTE) is a frequent and potentially life-threatening disease. Beyond the initial three months of anticoagulation, it is essential to evaluate accurately the recurrence risk of... more

Pre-operative physical performance as a predictor of in-hospital outcomes in older patients undergoing elective cardiac surgery

31 October 2020
Author(s): Samuele Baldasseroni, Alessandra Pratesi, Pierluigi Stefàno, Stefano Del Pace, Valter Campagnolo, Anna Chiara Baroncini, Aldo Lo Forte, Andrea Giosafat Marella, Andrea Ungar, Mauro Di Bari, Niccolò Marchionni, Italian Society of Geriatric Cardiology (SICGe)

Improved surgical techniques and intensive care management have dramatically reduced perioperative complications and mortality after cardiac surgery over the last two decades [1]. Therefore,... more

Serum uric acid and mortality thresholds among men and women in the Irish health system: A cohort study

19 October 2020
Author(s): Leonard D. Browne, Fatima-Zahra Jaouimaa, Cathal Walsh, Fernando Perez-Ruiz, Paschal Richette, Kevin Burke, Austin G. Stack

It is widely considered that serum uric acid (SUA), the final breakdown product of purine metabolism in humans, may represent a major cardiovascular risk factor and contribute to adverse health... more

Trends and outcomes of device-related 30-day readmissions after left ventricular assist device implantation

7 October 2020
Author(s): Alexandros Briasoulis, Hiroki Ueyama, Toshiki Kuno, Rabea Asleh, Paulino Alvarez, Aaqib H Malik

Newer generation, continuous-flow left ventricular assist devices (LVAD) have been introduced for use in end-stage heart failure as a bridge to transplant therapy or destination therapy, leading to... more

Seventeen-year trend (2001–2017) in pacemaker and implantable cardioverter-defibrillator utilization based on hospital discharge database data: An analysis by age groups

12 September 2020
Author(s): Massimo Zecchin, Marina Torre, Eugenio Carrani, Letizia Sampaolo, Enrico Ciminello, Benedetta Ortis, Renato Ricci, Alessandro Proclemer, Gianfranco Sinagra, Giuseppe Boriani

National Registries are needed to monitor health care interventions, optimize the resources and utilize them appropriately [1], but are challenging to implement and manage due to the possible lack... more

Baseline and incident hypochloremia in chronic heart failure outpatients: Clinical correlates and prognostic role

5 September 2020
Author(s): Maria Consiglia Bellino, Francesco Massari, Miriam Albanese, Raffaella Ursi, Gianmarco Angelini, Francesco Lisi, Luca Amato, Pietro Scicchitano, Pietro Guida, Natale Daniele Brunetti, Francesca Di Serio, Marco Matteo Ciccone, Massimo Iacoviello

Abnormalities in serum electrolyte levels often complicate heart failure (HF) disease in acute (ADHF) and chronic (CHF) settings. Serum sodium has long been considered the most important electrolyte... more

Low Creatinine Potentially Overestimates Glomerular Filtration Rate in Older Fracture Patients: A Plea for an Extensive Use of Cystatin C?

25 July 2020
Author(s): Iacopo Iacomelli, Antonella Giordano, Giulia Rivasi, Martina Rafanelli, Virginia Tortù, Alessandro Cartei, Carlo Rostagno, Mauro Di Bari, Niccolò Marchionni, Enrico Mossello, Andrea Ungar

The correct evaluation of renal function is crucial in clinical practice for diagnosis (e.g., imaging with contrast agents), treatment (e.g., drug dosing) and prognostic assessment (e.g., clinical... more

Review Article

The Brain-Gut-Microbiotal Axis: A framework for understanding functional GI illness and their therapeutic interventions

7 January 2021
Author(s): Christopher Tait, Gregory S. Sayuk

At the core of the BGA is a bidirectional network of communication between the central nervous system (CNS-brain, spinal cord) and the sensory and effector nerve complexes of the GI tract (Figure 1... more


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