July 2021

30 Articles

No Section

An elderly man with a locked jaw

10 June 2021
Author(s): Akitoshi Ueno, Ippei Sakamaki, Yoshihiro Yamamoto

An 86-year-old man with diabetes mellitus presented to our hospital with a 3-day history of difficulty opening his mouth. He reported that he had injured his right index finger while farming 15 days... more

Painless ulcer on the dorsal aspect of hand

31 May 2021
Author(s): Ting Dai, NingJing Song

A previously healthy 47-year-old man presented a 3-month history of progressive proliferative plaque and ulcer on the dorsal aspect of the right hand. Initially, the patient was bitten by an... more

Spirometry: A practical lifespan predictor of global health and chronic respiratory and non-respiratory diseases

17 May 2021
Author(s): Alvar Agusti, Leonardo M. Fabbri, Eugenio Baraldi, Bartolome Celli, Massimo Corradi, Rosa Faner, Fernando D. Martinez, Erik Melén, Alberto Papi

We propose that spirometry, a practical and validated marker of respiratory function, is also an overlooked marker of global human health throughout a person’s life span, from infancy to old age,... more

The importance of recognizing cerebral venous thrombosis following anti-COVID-19 vaccination

10 May 2021
Author(s): Alfonso Ciccone, Bruno Zanotti, The working group on cerebral venous thrombosis after COVID-19 vaccination

In March 2021, the reporting of cases of thrombosis post-COVID-19 vaccine AstraZeneca raised safety concerns and determined the temporary suspension of vaccinations in some countries in Europe [1].... more

Integrated approach to bronchoalveolar lavage cytology to distinguish interstitial lung diseases

28 April 2021
Author(s): Laura Bergantini, Miriana d'Alessandro, Paolo Cameli, Anna Perrone, Behar Cekorja, Bianca Boncompagni, Maria Antonietta Mazzei, Piersante Sestini, Elena Bargagli

Broncho-alveolar lavage (BAL) is a safe diagnostic procedure, useful for differentiating fibrotic lung disorders and for excluding malignancy and infection [1–5]. Together with chest high resolution... more

The efficacies of entecavir and tenofovir in terms of enhancing prognosis after curative treatment of hepatitis B virus–related hepatocellular carcinoma

30 March 2021
Author(s): Ji Hyun Lee, Beom Kyung Kim, Soo Young Park, Won Young Tak, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Dong Hyun Sinn, Seung Up Kim

Whether entecavir (ETV) or tenofovir disoproxil fumarate (TDF) affords the better prognosis after curative treatment of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains unclear... more

Clinical Insights

Thrombosis with Thrombocytopenia Syndrome associated with viral vector COVID-19 vaccines

25 May 2021
Author(s): Marco Cattaneo

On March 11 2021, the European Medical Agency highlighted two relevant issues, after the decision by the Danish Health Authority to temporarily suspend its vaccination campaign with Vaxzevria (the... more

SARS-CoV-2 vaccine-induced cerebral venous thrombosis

25 May 2021
Author(s): Alfonso Ciccone

Cerebral venous thrombosis (CVT) is a rare cause of stroke and intracranial hypertension syndrome. Compared to arterial stroke, CVT affects younger people, predominantly women, has a different risk... more


Antiviral therapy after curative treatment of hepatocellular carcinoma in patients with chronic hepatitis B infection: Is tenofovir or entecavir preferred?

19 May 2021
Author(s): Karel J. van Erpecum, Milan J. Sonneveld

Hepatitis B remains a major health problem. Globally, approximately 240 million persons are chronically infected (HBsAg positive). Prevalence is decreasing in highly endemic countries due to better... more


Myocardial infarction in giant cell arteritis: It is all a matter of balance.

28 June 2021
Author(s): Alessandro Tomelleri, Corrado Campochiaro, Lorenzo Dagna

Patients with giant cell arteritis (GCA) represent an extremely fragile population. This frailty arises from the combination of a chronic, highly inflammatory disease affecting patients invariably... more

D-dimer testing after anticoagulant discontinuation to predict recurrent venous thromboembolism

26 May 2021
Author(s): Stefano Barco, Frederikus A Klok

The duration of anticoagulant treatment after a first venous thromboembolism (VTE) depends on the risk of a VTE recurrence, which is mostly determined by the presence, type, persistence, and severity... more

Internal Medicine Flashcard

Woman with seizures

10 June 2021
Author(s): Zhen Hu, Wei Wen, Xutao Wang, Xinchao Zhang

A 66-year-old woman with a history of hyperlipidemia presented to the emergency department after a epileptic seizure episode for nearly 1 min. She had a normal temperature, pulse rate was 77 beats/... more

Recurrent facial palsy and fissured tongue

18 May 2021
Author(s): Mansi Sharma, Vijay K. Sharma

A 28-year old Chinese man presented with right facial paralysis for 8 days. He felt that for first 3-days, his right face was swollen that subsided after starting oral valaciclovir and prednisolone... more

Letter to the Editor

Type of anticoagulation therapy in oldest old, frail people with atrial fibrillation: Prescription modification over time. Authors' Reply

5 June 2021
Author(s): Valeria Calsolaro, Chukwuma Okoye, Sara Rogani, Alessia Maria Calabrese, Fabio Monzani

We would like to thank you for the opportunity to address the issues raised by A.Watanabe in his Letter to the Editor [1] and to clarify some methodological and analytical aspects of our study, while... more

Type of anticoagulation therapy in oldest old, frail people with atrial fibrillation

21 May 2021
Author(s): Atsuyuki Watanabe

Calsolaro V and colleagues indicated significant benefits of oral anticoagulants (OAC) in oldest-old patients with atrial fibrillation (AF) in the previously published article, entitled “Long-term... more

Direct oral anticoagulants versus enoxaparin in patients with atrial fibrillation and active cancer

10 May 2021
Author(s): Adi Elias, Yael Morgenstern, Eyal Braun, Benjamin Brenner, Inna Tzoran

Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. Benefits of anticoagulation therapy in reducing the risk of ischemic stroke in the majority of patients with AF are well-... more

Validation of the AF-ESUS score to identify patients with embolic stroke of undetermined source and low risk of device-detected atrial fibrillation

2 May 2021
Author(s): Alkisti Kitsiou, Dimitrios Sagris, Wolf-Rüdiger Schäbitz, George Ntaios

During the recent years, the term ESUS (embolic stroke of undetermined source) is used to describe patients with ischemic stroke for whom the source of embolism remains undetected despite recommended... more

Convalescent plasma in the management of COVID-19 pneumonia

29 April 2021
Author(s): Ayman Elbadawi, Mina Shnoda, Maryrose Laguio-Vila, Mamas A. Mamas, Islam Y. Elgendy

Few therapeutic agents have been proven to be effective in the management of COVID-19 pneumonia in randomized trials, thus the treatment options for this condition remain limited [1,2]. Convalescent... more

Healthcare students: should they be prioritized for COVID-19 vaccination?

29 April 2021
Author(s): Michele Augusto Riva, Maria Emilia Paladino, Michael Belingheri

Not requested.

Impact of rate control in hospitalized patients with atrial fibrillation and sepsis

24 April 2021
Author(s): Giulio Francesco Romiti, Marco Proietti

Sepsis is defined as a dysregulated host response to several types of infections [1], still representing a challenging issue in Medicine. Atrial Fibrillation (AF) frequently occurs in patients with... more

Iron deficiency in chronic myocarditis: Assessment and prognostic significance

20 April 2021
Author(s): Giovanni Peretto, Simone Sala, Clara Camaschella

Iron deficiency (ID) and associated anemia (IDA) represent major comorbidities in chronic diseases [1]. However, their prevalence and prognostic significance have never been investigated in... more

Prevalence of proximal deep vein thrombosis in hospitalized COVID-19 patients

8 April 2021
Author(s): Guillaume Reichert, Vincent Bunel, Dora Dreyfuss, Loukbi Saker, Antoine Khalil, Hervé Mal

Severe acute respiratory syndrome coronavirus 2(SARS-COV-2) is a novel virus that has spread worldwide since the end of 2019. Although a proportion of patients remains asymptomatic, the virus may be... more

Original Article

kinetics of anti-SARS-CoV-2 antibodies over time. Results of 10 month follow up in over 300 seropositive Health Care Workers

25 May 2021
Author(s): Jose F. Varona, Rodrigo Madurga, Francisco Peñalver, Elena Abarca, Cristina Almirall, Marta Cruz, Enrique Ramos, Jose María Castellano-Vazquez

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an unprecedented health emergency, causing over 125 million... more

Diagnostic accuracy of D-Dimer testing for recurrent venous thromboembolism: A systematic review with meta-analysis.

29 April 2021
Author(s): Matteo Nicola Dario Di Minno, Ilenia Calcaterra, Antimo Papa, Roberta Lupoli, Alessandro Di Minno, Mauro Maniscalco, Pasquale Ambrosino

With an annual incidence of 1-2 per 1,000 individuals, venous thromboembolism (VTE) is the third leading vascular diagnosis after heart attack and stroke [1,2]. VTE encompasses two interrelated... more

Serum uric acid and outcomes in patients with chronic heart failure through the whole spectrum of ejection fraction phenotypes: Analysis of the ESC-EORP Heart Failure Long-Term (HF LT) Registry

23 April 2021
Author(s): Giuseppe Ambrosio, Marisa G. Crespo Leiro, Lars H. Lund, Stefano Coiro, Andrea Cardona, Gerasimos Filippatos, Roberto Ferrari, Massimo F. Piepoli, Andrew J.S. Coats, Stefan D. Anker, Cécile Laroche, Luis Almenar-Bonet, Pentti Poder, David Bierge Valero, Anna Frisinghelli, Aldo P. Maggioni

Heart failure (HF) is a heterogeneous clinical syndrome, associated with a spectrum of metabolic disorders. Serum uric acid (sUA), the end-product of purine degradation, has shown prognostic value in... more

Joint effect of heart failure and coronary artery disease on the risk of death during hospitalization for COVID-19

19 April 2021
Author(s): Fabio Angeli, Jacopo Marazzato, Paolo Verdecchia, Antonella Balestrino, Claudio Bruschi, Piero Ceriana, Luca Chiovato, Laura Adelaide Dalla Vecchia, Roberto De Ponti, Francesco Fanfulla, Maria Teresa La Rovere, Francesca Perego, Simonetta Scalvini, Antonio Spanevello, Egidio Traversi, Dina Visca, Michele Vitacca, Tiziana Bachetti

Since the initial coronavirus (SARS-CoV-2) outbreak in the province of Wuhan, China, more than 50 million people have been infected so far, causing unnerving impact on routine patient care and... more

Adiponectin involved in portal flow hepatic extraction of 13C-methacetin in obesity and non-alcoholic fatty liver

15 April 2021
Author(s): Agostino Di Ciaula, Federico Carbone, Harshitha Shanmugham, Emilio Molina-Molina, Leonilde Bonfrate, Stefano Ministrini, Fabrizio Montecucco, Piero Portincasa

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease with a worldwide prevalence of about 30% [1]. NAFLD frequently occurs in overweight and obese individuals [... more

Myocardial infarction during giant cell arteritis: A cohort study

17 February 2021
Author(s): Hélène Greigert, Marianne Zeller, Alain Putot, Eric Steinmetz, Béatrice Terriat, Maud Maza, Nicolas Falvo, Géraldine Muller, Louis Arnould, Catherine Creuzot-Garcher, André Ramon, Laurent Martin, Georges Tarris, Tibor Ponnelle, Sylvain Audia, Bernard Bonnotte, Yves Cottin, Maxime Samson

Giant cell arteritis (GCA) is the most frequent vasculitis in adults over 50 years. It is a granulomatous large-vessel vasculitis mainly involving the aorta and cranial arteries [1–3]. Clinical signs... more

Research paper

SARS-CoV-2 antibody kinetics eight months from COVID-19 onset: Persistence of spike antibodies but loss of neutralizing antibodies in 24% of convalescent plasma donors

17 May 2021
Author(s): Evangelos Terpos, Dimitris Stellas, Margherita Rosati, Theodoros N. Sergentanis, Xintao Hu, Marianna Politou, Vassiliki Pappa, Ioannis Ntanasis-Stathopoulos, Sevasti Karaliota, Jenifer Bear, Duncan Donohue, Maria Pagoni, Elisavet Grouzi, Eleni Korompoki, George N. Pavlakis, Barbara K. Felber, Meletios A. Dimopoulos

The duration of antibody responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an area of extensive research in light of the new approvals of vaccines against SARS-CoV-2... more

Review Article

“Is medical cannabis safe for my patients?” A practical review of cannabis safety considerations

31 May 2021
Author(s): Caroline A. MacCallum, Lindsay A. Lo, Michael Boivin

The use of cannabis for medical purposes is increasing worldwide [5,32]. With the changing public and political opinion, more countries are implementing medical cannabis legalization. Although... more


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