July 2022

31 Articles

No Section

Adult anaphylaxis: To the heart of the matter

2 April 2022
Author(s): Antonio Mirijello, Salvatore De Cosmo

Dear Editor, we want to congratulate with Rossi and colleagues [1] for their state-of-the-art review summarizing pathophysiological mechanisms, diagnostic criteria, classification and clinical... more

Deployment of guideline-based therapy for heart failure with reduced ejection fraction: A word of caution for older patients

21 March 2022
Author(s): Mario Bo, Enrico Brunetti, Cecilia Noviello, Giuseppe Scala, Niccolò Marchionni

Dear Editor,

Beyond the Guidelines

Comparing atrial fibrillation guidelines: Focus on stroke prevention, bleeding risk assessment and oral anticoagulant recommendations

4 May 2022
Author(s): Jacopo Francesco Imberti, Davide Antonio Mei, Marco Vitolo, Niccolò Bonini, Marco Proietti, Tatjana Potpara, Gregory Y.H. Lip, Giuseppe Boriani

Clinical practice in atrial fibrillation (AF) patient management is constantly evolving. Non-vitamin K antagonist oral anticoagulants (NOACs) showed a favorable risk-benefit profile as compared to... more

Clinical Insights

Atrial cardiomyopathy: Pathophysiology and clinical implications

11 March 2022
Author(s): Antonella Tufano, Patrizio Lancellotti

The term atrial cardiomyopathy appears sporadically in the medical literature, and generally has been used in conjunction with atrial fibrillation (AF), or as “atrial fibrotic cardiomyopathy”, a... more


Conservative versus aggressive blood pressure reduction: Do we have a winner?

14 June 2022
Author(s): Dragan Lovic, Michael Doumas

Arterial hypertension is an established cardiovascular risk factor [1], while antihypertensive therapy is associated with substantial cardiovascular benefits [2]. Therefore, research in the field of... more

Intensive blood pressure control and cognitive impairment in chronic kidney disease: The jury is still out

29 May 2022
Author(s): Giorgio Gentile, Kathryn Mckinney, Gianpaolo Reboldi

Globally, 55 million people suffer from dementia, mainly Alzheimer's disease (60–70% of cases), and over 60% of patients live in low- or middle-income countries. This number is estimated to rise to... more

The search for a gold standard to clinically diagnose and monitor atrial cardiomyopathy

20 May 2022
Author(s): Giuseppe Boriani, Marco Vitolo, Jacopo Francesco Imberti

: Tufano A, Lancellotti P. "Atrial cardiomyopathy: Pathophysiology and clinical implications". Eur J Intern Med. 2022 Mar 11:S0953–6205(22)00097–8. doi: 10.1016/j.ejim.2022.03.007. Epub ahead of... more

Interleukin 6 inhibition in severe COVID-19: Another piece of the puzzle

24 April 2022
Author(s): Nicola Farina, Lorenzo Dagna

More than two years have passed since the beginning of the coronavirus disease 2019 (COVID-19) pandemic. Extensive efforts have been invested into better understanding the pathogenesis of this... more

Internal Medicine Flashcard

Heart failure: An autopsy case

15 May 2022
Author(s): Noemí Ramos-López, Melchor Saiz-Pardo Sanz, Isidre Vilacosta

A 78-year-old man with a history of bilateral carpal tunnel syndrome was admitted to our hospital with congestive heart failure. On physical examination a systolic ejection murmur was documented. B-... more

Persistent fever, bloody diarrhea, and skin necrosis in a young female

13 May 2022
Author(s): Eva Čubrić, Marijana Šupe, Ivan Krečak

A 28-year-old Caucasian female presented with a two-month history of low-grade fevers, abdominal cramps, occasional bloody stools, weight loss, high C-reactive protein (234 mg/L), and with a newly-... more

Hemolytic anemia in a patient with cirrhosis: Hiding in the smear!

25 March 2022
Author(s): Kyle Barron, Poornima Ramadas, Udhayvir Singh Grewal

A 41-year-old female with alcoholic liver cirrhosis presented to the emergency department with worsening abdominal pain and progressively worsening shortness of breath for two weeks. Laboratory... more

Vanishing tumor of the stomach

22 March 2022
Author(s): Yusaku Kajihara

A previously healthy Japanese 36-year-old man presented to the gastroenterology department with a 2-day history of acute-onset severe epigastric pain after eating flounder sashimi. His vital signs... more

Letter to the Editor

Exploring the recovery curve for long-term post-COVID dyspnea and fatigue

28 April 2022
Author(s): César Fernández-de-las-Peñas, José D. Martín-Guerrero, Ignacio Cancela-Cilleruelo, Paloma Moro-López-Menchero, Oscar J. Pellicer-Valero

Dear Editor

Adult anaphylaxis: To the heart of the matter. Author's reply

18 April 2022
Author(s): Carlo Maria Rossi, Marco Vincenzo Lenti, Antonio Di Sabatino

we read with interest the letter by Mirijello et al. [1] which emphasizes the importance of Kounis syndrome (KS), Takotsubo syndrome and their copresence in ATAK syndrome among cardiovascular... more

Concerns regarding result analysis and the corresponding risk of pulmonary embolism severity and in-hospital mortality

2 April 2022
Author(s): H Shafeeq Ahmed

I read with great interest the article by Miró et al., [1] as the paper discusses an important aspect of clinical medicine which is of great importance in the current coronavirus disease 2019 (COVID-... more

Lipoprotein Z, an abnormal LDL-like lipoprotein, independently predicts mortality in cirrhosis

1 April 2022
Author(s): Eline H. van den Berg, José Luis Flores-Guerrero, Robin P.F. Dullaart

Decreased plasma concentrations of high-density lipoproteins (HDL) make part of the lipoprotein abnormalities encountered in end-stage liver disease [1,2]. The liver plays a central role in both the... more

Community care reform in Italy: Get a move on!

18 March 2022
Author(s): Livio Garattini, Marco Badinella Martini, Alessandro Nobili

Dear editor

The role of heparin in reducing in-hospital complications and three-month mortality rates in hospitalized COVID-19 patients

16 March 2022
Author(s): F. Calabretta, P.S. Preti, M. Russo, C. Klersy, A. Di Sabatino

Many COVID-19 patients develop a coagulopathy characterized by thrombocytopenia, minor prolongation of bleeding times and elevated serum d-dimer and fibrinogen levels, similar to consumption... more

The precautionary principle in the COVID-19 vaccination campaign: The complicated relationship between the scientific community, medicines regulatory agencies and citizens

10 March 2022
Author(s): Paola Aurora Lobello, Alessandro Squizzato, Mario Picozzi

COronaVIrus Disease 19 (COVID-19) pandemia and vaccination campaign showed a frail relationship between the scientific community, medical authorities, and citizens. This clearly emerged when... more

Original Article

A prediction model for central venous catheter-related thrombosis in patients with newly-diagnosed acute myeloid leukemia: A derivation cohort analysis

5 May 2022
Author(s): Shay Perek, Alaa Khatib, Niv Izhaki, Ali Sleman Khalaila, Benjamin Brenner, Netanel A. Horowitz

Venous thromboembolism (VTE) is a major cause of morbidity and mortality in cancer patients. In a large population-based cohort study from Denmark, the VTE incidence within the first 6 months after... more

Hepatitis C Elimination in the Netherlands (CELINE): How nationwide retrieval of lost to follow-up hepatitis C patients contributes to micro-elimination

5 May 2022
Author(s): Cas J. Isfordink, Marleen van Dijk, Sylvia M. Brakenhoff, Patricia A.M. Kracht, Joop E. Arends, Robert J. de Knegt, Marc van der Valk, Joost P.H. Drenth, on behalf of CELINE Study Group

Achieving hepatitis C virus (HCV) elimination as a global health threat has been a priority of many countries since the World Health Organisation published their elimination targets [1]. In low-... more

Impact of eGFR rate on 1-year all-cause mortality in patients with stable coronary artery disease

2 May 2022
Author(s): Leonardo De Luca, Francesca Cappadona, Pier Luigi Temporelli, Lucio Gonzini, Antonietta Ledda, Arturo Raisaro, Francesca Viazzi, Domenico Gabrielli, Furio Colivicchi, Michele Massimo Gulizia, Roberto Pontremoli, On-Behalf-of-the-START-Investigators

The prevalence of chronic kidney disease (CKD) is currently around 10% in the general population, a figure that grows up to 30-50% in at-risk subgroups such as those with diabetes, hypertension or... more

Epidemiological and genetic features of anti-3‑hydroxy-3-methylglutaryl-CoA reductase necrotizing myopathy: Single-center experience and literature review

26 April 2022
Author(s): Diana Prieto-Peña, Javier G. Ocejo-Vinyals, Joel Mazariegos-Cano, Ana L. Pelayo-Negro, Sara Remuzgo-Martínez, Fernanda Genre, Alicia García-Dorta, Mónica Renuncio-García, Víctor M. Martínez-Taboada, Carmen García-Ibarbia, Julio Sánchez-Martín, Marcos López-Hoyos, Ricardo Blanco, Miguel A. González-Gay, José L. Hernández

alanine aminotransferase

Usefulness of telemedicine-based heart failure monitoring according to ‘eHealth literacy’ domains: Insights from the iCOR randomized controlled trial

25 April 2022
Author(s): Sergi Yun, Cristina Enjuanes, Esther Calero-Molina, Encarnación Hidalgo, Núria José-Bazán, Marta Ruiz, José María Verdú-Rotellar, Paloma Garcimartín, Santiago Jiménez-Marrero, Alberto Garay, Mar Ras, Raúl Ramos, Alexandra Pons-Riverola, Pedro Moliner, Xavier Corbella, Josep Comín-Colet

Notwithstanding new pharmacological and non-pharmacological approaches, such as optimising care using new monitoring strategies,[1,2] heart failure (HF) remains a huge public health problem worldwide... more

Echocardiographic markers of early alcoholic cardiomyopathy: Six-month longitudinal study in heavy drinking patients

10 April 2022
Author(s): Antonio Mirijello, Luisa Sestito, Christian Lauria, Claudia Tarli, Gabriele Angelo Vassallo, Mariangela Antonelli, Cristina d'Angelo, Anna Ferrulli, Filippo Crea, Anthony Cossari, Lorenzo Leggio, Salvatore De Cosmo, Antonio Gasbarrini, Giovanni Addolorato

Alcoholic cardiomyopathy (ACM) represents one of the leading causes of non-ischemic dilated myocardial disease in Western Countries [1]. ACM significantly contributes to the global burden of... more

Benefits of more intensive versus less intensive blood pressure control. Updated trial sequential analysis

6 April 2022
Author(s): Gianpaolo Reboldi, Fabio Angeli, Giorgio Gentile, Paolo Verdecchia

High blood pressure (BP) remains a dominant risk factor for cardiovascular disease and death worldwide [1,2]. The progressive decline in the incidence of cardiovascular disease, particularly stroke,... more

Interleukin-6 inhibitors reduce mortality in coronavirus disease-2019: An individual patient data meta-analysis from randomized controlled trials

6 April 2022
Author(s): Panagiotis T. Tasoudis, Christina K. Arvaniti, Anastasia T. Adamou, Ioannis Belios, John H. Stone, Nora Horick, Dimitrios Sagris, George N. Dalekos, George Ntaios

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and was declared a pandemic in March 2020 by the World Health Organization (WHO) [1]. Clinical manifestations... more

Review Article

Evolving concepts in the management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation

24 May 2022
Author(s): Dirk Jan van Ginkel, Willem L. Bor, Leo Veenstra, Arnoud W.J. van 't Hof, Enrico Fabris

Transcatheter aortic valve implantation (TAVI) is an effective and less invasive treatment option compared with conventional surgical aortic valve replacement (SAVR), and is the standard of care for... more

Acute kidney injury associated with non-steroidal anti-inflammatory drugs

6 May 2022
Author(s): Nattawat Klomjit, Patompong Ungprasert

Non-steroidal anti-inflammatory drugs (NSAIDs) are ones of the commonly prescribed drugs worldwide. They primarily inhibit cyclooxygenase (COX) enzyme which is responsible for conversion of... more

Intensive blood pressure control on dementia in patients with chronic kidney disease: Potential reduction in disease burden

21 April 2022
Author(s): Sidar Copur, Metehan Berkkan, Pantelis Sarafidis, Mehmet Kanbay

Chronic kidney disease (CKD) is defined by either presence of a decline in renal function, mostly assessed via creatinine or cystatin C-based estimated glomerular filtration rate (eGFR) measurements... more


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