Published: 6 May 2022
Author(s): Nattawat Klomjit, Patompong Ungprasert
Issue: July 2022
Section: Review Article

Non-steroidal anti-inflammatory drugs (NSAIDs) are ones of the commonly prescribed drugs worldwide. They primarily inhibit cyclooxygenase (COX) enzyme which is responsible for conversion of phospholipids to various prostaglandins (PGs). Disruption in PGs production affects the kidneys in several ways, including vasoconstriction that may result in ischemic acute kidney injury (AKI) in at-risk patients. They also impair salt and water excretion, leading to edema and hypertension. Other complications include hyperkalemia, hyponatremia, nephrotic syndrome, acute interstitial nephritis and chronic kidney disease progression.


Stay informed on our latest news!


This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.