Published: 27 April 2021
Author(s): Janine B Kastelijn, Maria ATC van der Loos, Paco MJ Welsing, Elisabeth Dhondt, Miriam Koopman, Leon MG Moons, Frank P. Vleggaar
Issue: June 2021
Section: Original article

Malignant biliary obstruction is an ominous complication of metastatic colorectal cancer (mCRC) and is associated with a poor prognosis.[1–3] It has been reported to occur in 10% of patients with known mCRC.[1] Malignant biliary obstruction can be caused by either intrahepatic metastases or extrahepatic lymph node or peritoneal metastases located at the liver hilum or along the extrahepatic bile duct. It significantly impacts clinical outcomes and is often treated in palliative settings. Median survival after the onset of jaundice is only around one month when treated with supportive care.


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