June 2021

28 Articles

No Section

Midregional proadrenomedullin safely reduces hospitalization in a low severity cohort with infections in the ED: a randomized controlled multi-centre interventional pilot study

24 April 2021
Author(s): Juan Gonzalez del Castillo, Carlota Clemente-Callejo, Ferran Llopis, Andreea Irimia, Fernando Oltra-Hostalet, Cindy Rechner, Andrej Schwabe, Verónica Fernandez-Rodriguez, Catalina Sánchez-Mora, Jordi Giol-Amich, Belén Prieto-García, Ignasi Bardés-Robles, Maria Dolores Ortega-de Heredia, Eric Jorge García-Lamberechts, Carmen Navarro-Bustos, INFURG-SEMES investigators

Patients with suspected infections presenting to the emergency department (ED) can potentially develop life-threatening conditions [1]. An early assessment of disease severity and the risk of disease... more

A case of suprapubic pain

20 April 2021
Author(s): Ankita Aggarwal, Anubhav Jain

A 71-year-old male with a past medical history of prostate cancer s/p radiation treatment seven years ago. He presented to the emergency department with acute onset pain in the suprapubic region. He... more

Weight-adjusted versus fixed dose heparin thromboprophylaxis in hospitalized obese patients: A systematic review and meta-analysis

19 April 2021
Author(s): Davide Ceccato, Angelo Di Vincenzo, Claudio Pagano, Raffaele Pesavento, Paolo Prandoni, Roberto Vettor

Venous thromboembolism (VTE) is a multi-factorial disease with high morbidity and mortality rates. As it has been reported to occur in about 100–200 cases/100,000 inhabitants per year [1], VTE... more

Safety of treatment with chloroquine and hydroxychloroquine: A ten-year systematic review and meta-analysis

5 April 2021
Author(s): Fernando Luiz Barros Edington, Sandra Rocha Gadellha, Mittermayer Barreto Santiago

Previously known as SN7618, chloroquine has been used since the early 1940s for the treatment of malaria [1]. In 1946 Loeb F. et al., in a statement approved by the board for coordination of malarial... more

Mid-term Prognostic Implication of hospitalized COVID-19 patients with Prior Heart Failure diagnosis

25 February 2021
Author(s): Pau Llàcer, Luis Manzano, Cristina Fernández, Mari Carmen Moreno, Julio Núñez

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that was diagnosed in late 2019 in Wuhan (China)[1]. It has spread... more


What is the role of growth-differentiation factor-15 in biomarker-based prediction of mortality in patients with atrial fibrillation?

11 May 2021
Author(s): Alexander P. Benz, John W. Eikelboom

Physicians often use risk prediction models to help guide diagnosis and inform patient management. Notable examples include the Framingham Risk Score, used to estimate the 10-year risk of coronary... more

Patients with Atrial Fibrillation receiving NOACs: The boundary between appropriate and inappropriate dose

7 May 2021
Author(s): Maria Cristina Vedovati, Michela Giustozzi, Maurizio Paciaroni

Since their introduction in 2010, non-vitamin K oral anticoagulants (NOACs) changed the landscape of stroke prevention in patients with atrial fibrillation (AF). Because of their favorable benefit-... more

The Times They Are A-Changin´: Antithrombotic strategies in patients with acute coronary syndrome undergoing coronary stenting who have concomitant atrial fibrillation

29 April 2021
Author(s): Trygve S. Hall, Dan Atar

Atrial fibrillation (AF) is a highly prevalent condition associated with an increased risk of cardioembolic strokes. Consequently, oral anticoagulation therapy has been established as a cornerstone... more

Internal Medicine Flashcard

Atypical cause of dysphagia

23 March 2021
Author(s): Dhairya A Lakhani, Aneri B Balar, Abdul R Tarabishy

A 27-years-old male presented with progressively worsening dysphagia for four years. The dysphagia was worse for solids, and for the past three months, the patient had restricted his diet to liquids... more

Letter to the Editor

Intermediate dose thromboprophylaxis in SARS-CoV-2 related venous thrombo embolism

26 March 2021
Author(s): Zahra Haider, Kanendran Rajalingam, Tanveer Khalid, Dilip Oswal, Akshay Dwarakanath

SARS-CoV-2 illness is associated with both pulmonary and extra pulmonary complications with hypoxemia being a marker of severity [1]. Evidence has shown an increase in venous thromboembolism (VTE)... more

Pre-admission atrial fibrillation in COVID-19 patients: Prevalence and clinical impact

18 March 2021
Author(s): Vincenzo Russo, Angelo Silverio, Fernando Scudiero, Pierpaolo Di Micco, Marco Di Maio

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic human coronavirus recently recognized as the cause of the coronavirus disease 2019 (COVID-19). Italy is one of the... more

Pneumothorax/pneumomediastinum in non-intubated COVID-19 patients: Differences between first and second Italian pandemic wave

18 March 2021
Author(s): Diego Palumbo, Corrado Campochiaro, Alessandro Belletti, Alessandro Marinosci, Lorenzo Dagna, Alberto Zangrillo, Francesco De Cobelli, for the COVID-BioB Study Group

Pneumothorax (PNX) and pneumomediastinum (PMD) have been frequently observed in mechanically ventilated patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (... more

Loneliness that destroys and upsets: A lesson from and beyond COVID-19

14 March 2021
Author(s): Christian Bracco, Remo Melchio, Elena Migliore, Chiara Marrale, Luigi Fenoglio

“I've often come up against the bad part about living”. A famous poem by the great poet Eugenio Montale represents well the situation of elderly patients admitted to our hospitals in recent months.

Hellenic Postprandial Lipemia Study (HPLS): Results from the Pre-treatment Postprandial Lipemia

10 March 2021
Author(s): Petros Kalogeropoulos, Helen Bilianou, Vana Kolovou, Athanasios Manolis, Genovefa D. Kolovou

Although fasting triglyceride (TG) levels are routinely measured in clinical practice, studies indicate that postprandial hypertriglyceridemia may be also related to atherosclerosis [1]. Currently,... more

Usefulness of step down units to manage survivors of critical Covid-19 patients

6 March 2021
Author(s): Piero Ceriana, Michele Vitacca, Mara Paneroni, Stefano Belli, Nicolino Ambrosino

The Coronavirus 2 (Covid-19) associated severe acute respiratory failure (ARF) has led to a huge number of admissions to intensive care units (ICU) with high fatality rates and shortage of beds. We... more

Is the “beach position” of value during the “eyeball” assessment of patients?

4 March 2021
Author(s): Alfred Lumala, John Kellett, Jelmer Alsma, Christian H Nickel

The rapid identification at low cost of patients at risk is particularly important in emergency departments in low- and middle-income countries, which may lack experienced emergency healthcare... more

DNA genotyping of the ABO gene showed a significant association of the A-group (A1/A2 variants) with severe COVID-19.

25 February 2021
Author(s): Juan Gómez, Guillermo M Albaiceta, Marta García-Clemente, José M. García-Gala, Eliecer Coto

The coronavirus disease 2019 (COVID-19) is caused by the new beta-coronavirus SARS-CoV-2. The virus has spread worldwide causing a pandemic with millions of infected. The adverse outcome is... more

Effectiveness and safety of high and low dose NOACs in patients with atrial fibrillation

18 February 2021
Author(s): Irene Marzona, Marco Proietti, Pierluca Colacioppo, Andreana Foresta, Marta Baviera

Non-vitamin K antagonist oral anticoagulants (NOACs) were marketed in 2011 as alternatives to Vitamin K Antagonists (VKA) for treatment of thromboembolic risk in atrial fibrillation (AF) patients.... more

Original Article

Clinical outcomes of biliary drainage of malignant biliary obstruction due to colorectal cancer metastases: A systematic review

27 April 2021
Author(s): Janine B Kastelijn, Maria ATC van der Loos, Paco MJ Welsing, Elisabeth Dhondt, Miriam Koopman, Leon MG Moons, Frank P. Vleggaar

Malignant biliary obstruction is an ominous complication of metastatic colorectal cancer (mCRC) and is associated with a poor prognosis.[1–3] It has been reported to occur in 10% of patients with... more

Adrenomedullin as a potential biomarker involved in patients with hereditary hemorrhagic telangiectasia

19 April 2021
Author(s): A. Iriarte, L. Ochoa-Callejero, J. García-Sanmartín, P. Cerdà, P. Garrido, J. Narro-Íñiguez, JM. Mora-Luján, A. Jucglà, MA Sánchez-Corral, F. Cruellas, E. Gamundi, J. Ribas, J. Castellote, F. Viñals, A. Martínez, A. Riera-Mestre

Hereditary hemorrhagic telangiectasia (HHT) or Rendu–Osler–Weber syndrome (ORPHA774) is a rare autosomal dominant vascular disease characterized by telangiectases and larger vascular malformations (... more

Efficacy and safety of steroid-sparing treatments in giant cell arteritis according to the glucocorticoids tapering regimen: A systematic review and meta-analysis

17 April 2021
Author(s): Anne-Laure Gérard, Noémie Simon-Tillaux, Youri Yordanov, Patrice Cacoub, Florence Tubach, David Saadoun, Agnès Dechartres

Giant cell arteritis (GCA) is the most common systemic vasculitis in Western countries, with an annual incidence of 10 to 20 per 100,000 adults older than 50 years and increasing with age [1]. Its... more

Post-discharge antithrombotic management and clinical outcomes of patients with new-onset or pre-existing atrial fibrillation and acute coronary syndromes undergoing coronary stenting: Follow-up data of the MATADOR-PCI study

7 April 2021
Author(s): Leonardo De Luca, Andrea Di Lenarda, Andrea Rubboli, Leonardo Bolognese, Lucio Gonzini, Federico Fortuni, Alessandro Navazio, Fabrizio Poletti, Antonietta Ledda, Stefano Urbinati, Domenico Gabrielli, Michele Massimo Gulizia, MATADOR-PCI Investigators

. Patients with concomitant atrial fibrillation (AF) and acute coronary syndromes (ACS) do not seem to receive proper antithrombotic therapies and present high rates of adverse clinical events.

Sex-specific differences in the presentation, clinical course, and quality of life of patients with acute venous thromboembolism according to baseline risk factors. Insights from the PREFER in VTE

30 March 2021
Author(s): Michela Giustozzi, Luca Valerio, Giancarlo Agnelli, Cecilia Becattini, Eva-Maria Fronk, Frederikus A. Klok, Stavros V. Konstantinides, Maria Cristina Vedovati, Alexander T. Cohen, Stefano Barco

The presentation and prognosis of venous thromboembolism (VTE) are known to be characterized by considerable sex differences. While men and women have a similar overall risk of developing a first... more

Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19

26 March 2021
Author(s): George N. Dalekos, Aggelos Stefos, Sarah Georgiadou, Vasiliki Lygoura, Anastasia Michail, George Ntaios, Anna Samakidou, George Giannoulis, Stella Gabeta, Marianna Vlychou, Efthymia Petinaki, Konstantinos Leventogiannis, Evangelos J. Giamarellos-Bourboulis, Nikolaos K. Gatselis

Aims Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may lead to the development of severe respiratory failure. In hospitalized-patients, prompt interruption of the virus-... more

Growth differentiation factor-15 predicts major adverse cardiac events and all-cause mortality in patients with atrial fibrillation

8 March 2021
Author(s): Stephan Nopp, Oliver Königsbrügge, Daniel Kraemmer, Ingrid Pabinger, Cihan Ay

Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with high morbidity and mortality, largely attributable to an increased risk of stroke and systemic embolism.... more

Review Article

The use of β-blockers in patients with heart failure and comorbidities: Doubts, certainties and unsolved issues

30 April 2021
Author(s): Stefania Paolillo, Simona Dell'Aversana, Immacolata Esposito, Alessandra Poccia, Pasquale Perrone Filardi

β-blockers represent a mainstay in the pharmacological approach to patients affected by heart failure with reduced ejection fraction (HFrEF). However, underuse of this class of drugs is still... more

SARS-CoV-2 vaccines: Lights and shadows

29 April 2021
Author(s): Fabio Angeli, Antonio Spanevello, Gianpaolo Reboldi, Dina Visca, Paolo Verdecchia

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread across the world and killed more than 2.9 million individuals globally, with 137 million cases being confirmed by... more

Rabies in Europe: An epidemiological and clinical update

29 April 2021
Author(s): Niccolò Riccardi, Andrea Giacomelli, Roberta Maria Antonello, Federico Gobbi, Andrea Angheben

Rabies is a vaccine preventable zoonosis with a significant mortality burden worldwide, causing about 60,000 deaths each year [1]. Nevertheless, rabies is still a neglected disease [2]. Rabies is... more


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