Pneumothorax (PNX) and pneumomediastinum (PMD) have been frequently observed in mechanically ventilated patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS), with a reported rate up to 24% [1]. No study has evaluated so far the exact rate of these events in non-intubated COVID-19 patients. We therefore decided to perform an observational study to investigate the rate of PNX/PMD in non-intubated COVID-19 patients and to compare the rate of PNX/PMN between patients admitted during the first and second Italian pandemic wave.