Published: 4 April 2022
Author(s): Jetta J. Oppelaar, Mart D. Vuurboom, Eliane F.E. Wenstedt, Frans J. van Ittersum, L. Vogt, Rik H.G. Olde Engberink
Issue: June 2022
Section: Original article

Hypernatremia and hyponatremia, are commonly encountered electrolyte disturbances in clinical practice [1,2]. The pathophysiology underlying these disturbances is complex and clinicians often face diagnostic and therapeutic difficulties [3,4]. Adequate treatment is critical, since these electrolyte disorders are associated with increased morbidity and mortality, yet overly rapid correction can lead to severe brain injury [5]. Treatment is often guided by formulas predicting changes in plasma sodium concentration following hypertonic saline infusion or correction of water deficit.


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