June 2022
31 ArticlesNo Section
Is malignancy cancer an adverse factor of in-hospital clinical outcome in post-cardiac arrest?
With the continuous development of cancer treatment, patients with cancer have dramatically improved, with several cancer populations experiencing a median survival well beyond 5 years.1 However,... more
Double-gloving in an Intensive Care Unit during the COVID-19 pandemic
Dear Editor,
Clinical Insights
Anticoagulation as secondary prevention of massive lung thromboses in hospitalized patients with COVID-19
Since February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been responsible for one of the major pandemic we have experienced in the last 100 years [1]. The most... more
Commentary
Dual antiplatelet treatment for minor acute ischemic stroke and high-risk transient ischemic attack: have we reached the limit of antithrombotic management?
In this issue of the European Journal of Internal Medicine Pomero et al. present their systematic review and meta-analysis evaluating the early use of clopidogrel and ticagrelor in addition to... more
Ultrasound evaluation of bowel vasculopathy in systemic sclerosis but…
The gastrointestinal (GI) tract is affected in up to 90% of patients with systemic sclerosis (SSc). SSc is a key contributor to impairment and disability, leading to remarkable abnormal social... more
The importance of consensus statements on the prevention and treatment of cancer-associated thrombosis
Venous thromboembolism (VTE) is a common complication among patients with cancer. The 6-month risk of VTE complication for cancer patients is 12-fold higher and as much as 23-fold higher in those... more
The unresolved issues in the management of mucormycosis
Mucormycosis represents the second most frequent invasive mold infection after invasive aspergillosis and its incidence tends to increase around the world [1]. The disease not only affects patients... more
Ideas and Opinions
Reflections on experimentation in medicine
Empirical medicine – over centuries - has been based on close observation of the patient`s history and the sick body. Thus, the ancient Greeks had already concepts of human anatomy, organ functions... more
Internal Medicine Flashcard
Diffuse pulmonary ill-defined centrilobular opacities: Not only bronchiolitis
metastatic pulmonary calcification
Chilblain-like acral lesions
A 70-year-old Asian female presented to the rheumatology clinic with a 5-year history of tender papules on fingers and toes aggravated under cold exposure. She also reported polyarthralgia and... more
Granulomatous lesions of the skin: Do not fall into the trap
A 51-year-old woman was referred to investigate skin lesions present on her backside.
A man with fever and aortitis
A 54-year-old man presented with a chief complaint of fever and pain around the left clavicle. He had a primary germ cell tumor of the mediastinum and had been undergoing chemotherapy for... more
Letter to the Editor
Doubtful clinical benefit of casirivimab-imdevimab treatment for disease severity outcome of high-risk patients with SARS-CoV-2 delta variant infection
To the editor,
Assessment of the clinical characteristics of ampicillin-susceptible Enterococcus faecium infection
Dear Editor,
Health-care associated infections surveillance in elderly patients
Dear Editor, according with the WHO, Health-Care Associated Infections (HCAIs) are the most frequent adverse events during care delivery and represent a great clinical and economic burden [1]. In... more
Diabetes influences the performance of creatinine-based equations for estimating glomerular filtration rate in the elderly population
The number of people older than 65 years with diabetes was 135.6 million in 2019, and will reach 276.2 million by 2045 [1]. Additionally, the estimated prevalence of diabetes in adults today has... more
Impact of therapeutic plasma exchange on acquired vaccinal anti-SARS-CoV-2 antibodies
As of December 2021, more than 276 million affected cases and 5 million deaths were reported by the World Health Organization, due to the COVID-19 pandemic [1]. Following the outbreak's beginning,... more
Is the number of long-term post-COVID symptoms relevant in hospitalized COVID-19 survivors?
Dear editor,
Perspectives of European internists on multimorbidity. A multinational survey
Dear Editor,
Original Article
Effects of non-invasive respiratory supports on inspiratory effort in moderate-severe COVID-19 patients. A randomized physiological study
Non-invasive respiratory support (NRS), such as, Continuous Positive Airway Pressure (CPAP), High Flow Nasal Cannula (HFNC) or non-invasive ventilation (NIV), have been successfully applied to manage... more
Asymptomatic coronary artery disease assessed by coronary computed tomography in patients with systemic lupus erythematosus: A systematic review and meta-analysis
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with female predominance: cardiovascular disease (CVD) is the leading cause of morbidity and mortality. Accelerated atherosclerosis... more
Reconsidering the Edelman equation: impact of plasma sodium concentration, edema and body weight
Hypernatremia and hyponatremia, are commonly encountered electrolyte disturbances in clinical practice [1,2]. The pathophysiology underlying these disturbances is complex and clinicians often face... more
Non-alcoholic fatty liver disease: identical etiologic factors in patients with type 1 and type 2 diabetes
Alongside the obesity-epidemic, non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide, with an estimated prevalence of 25% in the general population [1... more
Incidence of endocrine and exocrine insufficiency in patients with autoimmune pancreatitis at diagnosis and after treatment: a systematic review and meta-analysis
Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis that can lead to end-stage organ damage if left untreated [1]. To date, at least two different subtypes of AIP have been... more
P2Y12 inhibitors plus aspirin for acute treatment and secondary prevention in minor stroke and high-risk transient ischemic attack: A systematic review and meta-analysis
Stroke is a leading cause of mortality and disability worldwide [1] and approximately 20 to 25% of ischemic stroke are anticipated by transient ischemic symptoms [2]. The risk of ischemic stroke... more
Association between admission ECG changes and long-term mortality in patients with an incidental myocardial infarction: Results from the KORA myocardial infarction registry
Acute myocardial infarction (AMI) is a major cause of morbidity and mortality in Germany and worldwide [1,2]. It is grouped into two main categories according to admission ECG: ST-Elevation... more
Survival in rhino-orbito-cerebral mucormycosis: An international, multicenter ID-IRI study
Mucormycosis is an aggressive mold infection that mostly attacks patients with certain underlying conditions such as diabetes, hematological malignancies, neutropenia, major solid organ... more
Consensus on prevention and treatment of cancer-associated thrombosis (CAT) in controversial clinical situations with low levels of evidence
Venous thromboembolism (VTE) is a leading cause of morbidity and mortality among cancer patients. They develop more VTE than those without cancer and experience higher rates of VTE recurrence and... more
Ultrasound evaluation of bowel vasculopathy in systemic sclerosis
Systemic sclerosis (SSc) is a complex disease with a heterogenous clinical spectrum and a complex pathophysiology characterized by immune activation and diffuse microvascular injury resulting in... more
Review Article
Sodium glucose cotransporter-2 inhibitors protect the cardiorenal axis: Update on recent mechanistic insights related to kidney physiology
Diabetic kidney disease (DKD) is a common complication of diabetes, affecting ∼ 40% of patients with type 2 diabetes (T2D) [1]. DKD is characterized by increased urinary albumin excretion and/or... more
Adult anaphylaxis: A state-of-the-art review
Anaphylaxis is an acute, usually rapidly developing, systemic (involving multiple organs) allergic reaction and, among the various clinical forms of allergy, it is the most severe and potentially... more