November 2023

29 Articles

Clinical Insights

The peculiarities of COVID-19 in older people: Considerations after two years

29 September 2023
Author(s): Caterina Trevisan, Chukwuma Okoye, Raffaele Antonelli Incalzi, GeroCovid Working Groups

As written by Cicero in De finibus, Aristotle said, “Hominem ad duas res, ad intelligendum et ad agendum, esse natum”, i.e. “Man is born for two things: to understand and to act”. The path of the... more

Body Mass Index (BMI): Still be used?

13 September 2023
Author(s): Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao

The Body Mass Index (BMI) is a commonly used measure that calculates an individual's body weight in relation to their height [1]. It was developed by Adolphe Quetelet in the early 19th century and... more


Standing up for equitable treatment of coronary microvascular dysfunction and myocardial infarction with non-obstructive coronary arteries

25 September 2023
Author(s): Alexander C. Fanaroff, Renato D. Lopes

Myocardial infarction (MI) with normal coronary arteries (MINOCA) and ischemia with normal coronary arteries (INOCA) are syndromes characterized by evidence of myocardial necrosis or myocardial... more

Renal denervation trials in hypertension – what we wait for in 2023/2024

18 September 2023
Author(s): Felix Mahfoud, Michael Kunz, Felix Götzinger

Arterial hypertension is the most frequent modifiable cardiovascular risk factor and remains a leading cause of premature death worldwide with increasing prevalence [1]. Epidemiologic studies suggest... more


The new international nomenclature for steatotic liver disease: One step forward towards enhanced awareness for healthier life

14 September 2023
Author(s): Karel J. van Erpecum, Laurens A. van Kleef, Ulrich Beuers, Robert J. de Knegt

Steatotic liver disease (SLD) is the most common liver disease worldwide and a leading cause of liver-related morbidity and mortality. Current prevalence of SLD is approximately 30 % of the global... more

Ideas and Opinions

Addressing the paradox: Health expansion threatening sustainable healthcare

19 September 2023
Author(s): Bjørn Hofmann

We need to address the paradox that health expansion threatens sustainable healthcare as anti-aging drugs are on the trail from trial to the market and come together with health enhancement measures... more

Internal Medicine Flashcard

Young woman with red eyes and shock

22 August 2023
Author(s): Hiroki Matsuura, Masayuki Kishida

A 21-year-old previously healthy Japanese woman with one-week history of fever, sore throat, chills, nausea, vomiting, abdominal pain, and watery diarrhea presented to our emergency department.... more

A man with widespread subcutaneous fat necrosis and osteonecrosis

1 August 2023
Author(s): Shu Yoshihara, Shioto Suzuki, Taku Yaegashi

A man in his forties with a history of alcohol abuse (200 g/day) presented with progressive multiple joint pain. He did not have abdominal, respiratory or urinary complaints. Physical examination... more

Letter to the Editor

The old and the new: The EG.5 (‘Eris’) sub-variant of Coronavirus

8 September 2023
Author(s): Martina Zappa, Paolo Verdecchia, Andrea Andolina, Fabio Angeli

In the last year of pandemic, several variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been identified and monitored. Indeed, the persisting challenges of SARS-CoV-2 to... more

Fixing the Achilles heel of electronic medical records: Vital information must be defined, concise, accurate and easily accessible

25 August 2023
Author(s): John Kellett, Niclas Skyttberg, Rijk Gans, Frank Sebat, Runolfur Palsson

Although electronic medical records (EMR) have many potential benefits, one of their unintended consequences it that many physicians may now spend most of their working hours at a computer screen... more

Does a multidisciplinary team involving internists specialized in hypertension and obstetric medicine improve pregnancy outcomes?

20 August 2023
Author(s): Federica Piani, Daniela Degli Esposti, Davide Agnoletti, Claudio Borghi, Bologna HDP Study Group

The prevalence of hypertensive disorders of pregnancy (HDP) steadily increased in past years partly because of advanced maternal age and partly because of ever-wider access to assisted reproduction... more

Polyautoimmunity in IgG4-related disease

17 August 2023
Author(s): Gabriela Hernández-Molina, Eduardo Martín-Nares

Dear Editor,

Diagnoses associated with temporal arteritis

14 August 2023
Author(s): Fabien Pontille, Paul Decker, Guillaume Gauchotte, Roland Jaussaud, Thomas Moulinet

The diagnosis of giant cell arteritis (GCA), the most common vasculitis after the age of 50, relies on a body of evidence, among which temporal arteritis (TA) remains a cornerstone [1]. However, TA... more

Spontaneous coronary artery dissection and Takotsubo syndrome

14 August 2023
Author(s): Andrea Denegri, Lukasz Szarpak, Michal Pruc, Milosz J. Jaguszewski

Spontaneous coronary artery dissection (SCAD) and Takotsubo syndrome (TTS) are increasingly recognized. Both conditions predominantly affect females, with an incidence of up to 4% in patients... more

Undiagnosed cognitive impairment in older adults hospitalized in internal medicine wards: Data from the REPOSI registry

4 August 2023
Author(s): Pasquale Agosti, Alessio Novella, Carlo Custodero, Chiara Elli, Luca Pasina, REPOSI Investigators

Dear Editor,

Prognostic role of the left ventricular global function index companion in patients with chronic heart failure

31 July 2023
Author(s): Vera N. Larina, Viktor I. Lunev

Heart failure (HF) is characterized by significant morbidity, mortality, economic burden and low quality of life. The global prevalence of HF among patients aged 50 years and older averages 8.3%, the... more

Original Article

Predictive value of Killip classification in MINOCA patients

16 August 2023
Author(s): Matteo Armillotta, Sara Amicone, Luca Bergamaschi, Francesco Angeli, Andrea Rinaldi, Pasquale Paolisso, Andrea Stefanizzi, Angelo Sansonetti, Andrea Impellizzeri, Francesca Bodega, Lisa Canton, Nicole Suma, Damiano Fedele, Davide Bertolini, Alberto Foà, Carmine Pizzi

In the last two decades, the better understanding of acute myocardial infarction (AMI) pathophysiology as well as the advances in medical therapy and hemodynamical techniques led to a decrease in the... more

Catheter-based renal artery denervation: facts and expectations

4 August 2023
Author(s): Paolo Verdecchia, Claudio Cavallini, Rocco Sclafani, Andrea Santucci, Francesco Notaristefano, Gianluca Zingarini, Giovanni Andrea Colombo, Fabio Angeli

Some clinical studies published before year 2014 raised consistent expectations worldwide on a promising role of catheter-based renal artery denervation (RAD) in the management of patients with... more

Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis

25 July 2023
Author(s): Simone Marcella, Angelica Petraroli, Luisa Canè, Anne Lise Ferrara, Remo Poto, Roberta Parente, Francesco Palestra, Leonardo Cristinziano, Luca Modestino, Maria Rosaria Galdiero, Maria Monti, Gianni Marone, Massimo Triggiani, Gilda Varricchi, Stefania Loffredo

Mastocytosis is a heterogeneous, rare disease associated with uncontrolled proliferation, accumulation, and increased survival of mast cells (MCs) in different organs [1]. This pathological condition... more

GLIM-diagnosed malnutrition predicts mortality and risk of hospitalization in systemic sclerosis: A retrospective study

21 July 2023
Author(s): Edoardo Rosato, Antonietta Gigante, Amalia Colalillo, Chiara Pellicano, Danilo Alunni Fegatelli, Maurizio Muscaritoli

Systemic sclerosis (SSc) is an autoimmune disease characterized by microcirculation dysfunction, autoantibodies production, progressive skin and multiorgan fibrosis with potentially life-threatening... more

Prevalence of anti-synthetase antibodies among systemic sclerosis patients

13 July 2023
Author(s): Wakar Garra, Yair Levy

Systemic sclerosis (SSc) is a rare, multisystem autoimmune disease. It is divided according to the extent of skin involvement, into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) [1...

Clinicopathological characteristics, risk factors and prognostic value of intrarenal vascular lesions in IgA nephropathy

12 July 2023
Author(s): Yiping Ruan, Fuyuan Hong, Miao Lin, Chen Wang, Fayang Lian, Fang Cao, Guokai Yang, Lanting Huang, Qiaoyun Huang

IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide, which is characterized by the predominant deposition of IgA in the glomerular mesangium. Although prevalence of... more

Intravenous immunoglobulin therapy in antineutrophil cytoplasmic antibody-associated vasculitis

1 July 2023
Author(s): Fabricio Benavides-Villanueva, Javier Loricera, Vanesa Calvo-Río, Cristina Corrales-Selaya, Santos Castañeda, Ricardo Blanco

According to the International Chapel Hill Consensus Conference 2012 (CHCC2012), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a group of necrotizing vasculitis, with... more

Aortic stiffness plays a role in the discrepancy between mitral valve lesion severity and hemodynamic burden of secondary mitral regurgitation.

29 June 2023
Author(s): Caterina Maffeis, Andrea Rossi, Stefano Bonapace, Lorenzo Cannata, Elvin Tafciu, Mariantonietta Cicoira, Pier Luigi Temporelli

The disproportionate/proportionate nature of secondary mitral regurgitation (sMR) has been recently introduced to explain the different outcomes of patients undergoing percutaneous mitral valve... more

Review Article

Coronary microvascular dysfunction and myocardial infarction with non-obstructive coronary arteries: Where do we stand?

22 July 2023
Author(s): Abdul-Quddus Mohammed, Fuad A. Abdu, Lu Liu, Guoqing Yin, Redhwan M. Mareai, Ayman A. Mohammed, Yawei Xu, Wenliang Che

The term myocardial infarction with non-obstructive coronary arteries (MINOCA) was first coined in 2013 [1] and was globally recognized in an expert position paper as a clinically heterogeneous... more

Albumin administration in internal medicine: A journey between effectiveness and futility

7 July 2023
Author(s): Enrico Pompili, Giacomo Zaccherini, Maurizio Baldassarre, Giulia Iannone, Paolo Caraceni

Human albumin is the most abundant circulating protein and accounts for approximately 50–60% of all total plasma proteins in healthy individuals. The molecule is composed of 585 amino acids organised... more

Management of diabetic ketoacidosis

5 July 2023
Author(s): Leonid Barski, Evgeny Golbets, Alan Jotkowitz, Dan Schwarzfuchs

Diabetic ketoacidosis (DKA) is an acute life-threatening emergency in patients with diabetes, characterized by hyperglycemia, metabolic acidosis and ketonemia, it can result in serious morbidity and... more

Axial Spondyloarthritis: Evolving concepts regarding the disease's diagnosis and treatment

5 July 2023
Author(s): Alexandros A. Drosos, Aliki I. Venetsanopoulou, Paraskevi V. Voulgari

Spondyloarthritis (SpA) is a group of inflammatory diseases characterized by the involvement of the axial skeleton (axSpA) and/or the peripheral joints (p-SpA). It affects young adults of both sexes... more


Stay informed on our latest news!


This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.